Mechanical Stretch and Cytokines
Mechanical Stretch and Cytokines

Author: Andre Kamkin

Publisher: Springer Science & Business Media

Published: 2011-09-06

Total Pages: 247

ISBN-13: 9400720041

DOWNLOAD EBOOK

This book presents the latest findings in the field of investigation of molecular mechanisms of mechanical stretch and the role of cytokines in response of different tissues to it. On the one hand this Volume demonstrates how mechanical stretch enhances cytokines production. It describes how cytokines influence tissues and cells on a background of a mechanical stretching. It provides a description of how cells in different tissues are activated by stretch and cytokines via various signaling pathways, and how they change their gene expression. The book is a unique collection of reviews outlining current knowledge and future developments in this rapidly growing field. Knowledge of biomechanics, and mechanisms which underlie it on molecular, cellular and tissue, is necessary for understanding of the normal functioning of living organisms and allows to predict changes, which arise due to alterations of their environment.

Clinical Immunology
Clinical Immunology

Author: Robert R. Rich

Publisher: Mosby Incorporated

Published: 2008

Total Pages: 1578

ISBN-13: 9780323044042

DOWNLOAD EBOOK

Offers answers to challenges in clinical immunology. This book contains immunology knowledge and includes a companion web site to give you two ways to find the answers you need.

Stretch Intensity and the Inflammatory Response: A Paradigm Shift
Stretch Intensity and the Inflammatory Response: A Paradigm Shift

Author: Nikos C. Apostolopoulos

Publisher: Springer

Published: 2018-12-27

Total Pages: 239

ISBN-13: 3319968009

DOWNLOAD EBOOK

In this manuscript, practitioners and students who are concerned with sports and rehabilitation medicine, kinesiology, as well as coaches and athletes, are introduced to numerous concepts, including mechanotransduction, inflammation, pro- and anti-inflammatory cytokines, calpains, the extracellular matrix, neutrophils and macrophages, and their relevance to stretching, particularly stretching intensity. Although the quantitative parameters of training, duration, and frequency are important, it is the qualitative criterion of intensity (“how much”) that the author suggests is ultimately of greater concern. Intensity, the rate and magnitude of force, may be responsible for the proper recovery, regeneration, and adaptation of the musculoskeletal tissues from training, competition, or rehabilitation from injuries. Research suggests that too much force results in the stimulation of an inflammatory response, one associated with a biochemical feedback emerging from a mechanical stimulus. The intent of this manuscript is twofold: to initiate the discussion of the importance of stretching intensity with regard to proper recovery, regeneration, and adaptation, and to suggest that researchers need to explore its potential role in addressing numerous inflammatory (RA) and non-inflammatory (OA, recurrent tendinitis etc.) musculoskeletal conditions as well.

The Functional Anatomy of the Reticular Formation
The Functional Anatomy of the Reticular Formation

Author: Ugo Faraguna

Publisher: Frontiers Media SA

Published: 2019-10-04

Total Pages: 154

ISBN-13: 2889630285

DOWNLOAD EBOOK

The brainstem reticular formation is the archaic core of ascending and descending pathways connecting the brain with spinal cord. After the pioneer description of the activating role of the ascending reticular activating system by Moruzzi and Magoun in 1949, an increasing number of studies have contributed to disclose the multifaceted roles of this brain area. In fact, the brainstem reticular formation sub-serves a variety of brain activities such as the modulation of the sleep-waking cycle, the level of arousal and attention, the drive for novelty seeking behaviors and mood. Meanwhile, descending pathways play a key role in posture modulation, extrapyramidal movements, and autonomic functions such as breathing and blood pressure. Moreover, both descending and ascending fibers of the reticular formation are critical in gating the sensory inputs and play a critical role in pain modulation and gaze control. All these activities are impaired when a damage affects critical nuclei of the reticular formation. Remarkably, in neurodegenerative diseases involving reticular nuclei, the rich collaterals interconnecting reticular isodendritic neurons represent a gateway for disease spreading placing the role of the reticular nuclei as a pivot in a variety of brain disorders. The present Research Topic is an updated collection of recent studies, which contribute to define the systematic anatomy of the reticular formation, its physiological and pharmacological features, as well as its involvement in neurodegenerative disorders and neuroprotection.

The Role of Inflammatory Mediators in the Failing Heart
The Role of Inflammatory Mediators in the Failing Heart

Author: Douglas L. Mann

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 111

ISBN-13: 1461514495

DOWNLOAD EBOOK

Although clinicians have recognized the importance of inflammatory mediators in the pathogenesis of heart disease for well over 200 years, it has taken nearly as many years for clinicians and scientists to focus on the basic biological mechanisms by which inflammatory mediators contribute to the pathogenesis of cardiac disease states. Over the past decade there has been increasing interest in the potential role that inflammatory mediators, play in a variety of cardiac disease states, including chronic heart failure. The Role of Inflammatory Mediators in the Failing Heart provides a state-of-the-art review on inflammatory mediators and the failing heart. This book will serve both as a useful introduction to the field, as well as an update for those interested in the role of inflammatory mediators and the failing heart.

Bronchopulmonary Dysplasia
Bronchopulmonary Dysplasia

Author: Vineet Bhandari

Publisher: Humana Press

Published: 2016-03-15

Total Pages: 357

ISBN-13: 331928486X

DOWNLOAD EBOOK

This book provides a comprehensive framework for treatment and management of bronchopulmonary dysplasia. In recent years great strides have been made toward understanding the pathogenesis and clinical aspects of BPD, which is the most common chronic lung disease affecting infants. This one-stop resource is written by leading scientists and clinicians in the field, and chapters discuss the most recent developments in the basic scientific, translational, and clinical characteristics of the disease. Topics such as hyperoxia, pre- and post-natal inflammation, and genetics and biomarkers of BPD are included, as well as non-invasive ventilation techniques, nutrition, and radiology applications from pre-term birth to adulthood. The book closes with an in-depth look at emerging therapeutic options for prevention of BPD. Bronchopulmonary Dysplasia is an essential volume for all neonatologists, pediatric pulmonologists, and scientists interested in developmental disorders of the lung.

Mechanical Ventilation
Mechanical Ventilation

Author: Peter J. Papadakos

Publisher: Elsevier Health Sciences

Published: 2007-01-01

Total Pages: 684

ISBN-13: 0721601863

DOWNLOAD EBOOK

One of the key tools in effectively managing critical illness is the use of mechanical ventilator support. This essential text helps you navigate this rapidly evolving technology and understand the latest research and treatment modalities. A deeper understanding of the effects of mechanical ventilation will enable you to optimize patient outcomes while reducing the risk of trauma to the lungs and other organ systems. A physiologically-based approach helps you better understand the impact of mechanical ventilation on cytokine levels, lung physiology, and other organ systems. The latest guidelines and protocols help you minimize trauma to the lungs and reduce patient length of stay. Expert contributors provide the latest knowledge on all aspects of mechanical ventilation, from basic principles and invasive and non-invasive techniques to patient monitoring and controlling costs in the ICU. Comprehensive coverage of advanced biological therapies helps you master cutting-edge techniques involving surfactant therapy, nitric oxide therapy, and cytokine modulators. Detailed discussions of both neonatal and pediatric ventilator support helps you better meet the unique needs of younger patients.

Muscle Cell and Tissue
Muscle Cell and Tissue

Author: Kunihiro Sakuma

Publisher: BoD – Books on Demand

Published: 2018-10-10

Total Pages: 372

ISBN-13: 1789840058

DOWNLOAD EBOOK

In order to complete tissue regeneration, various cells (neuronal, skeletal and smooth) interact coordinately with each other. This book, Muscle Cell and Tissue - Current Status of Research Field, deals with current progress and perspectives in a variety of topics on the skeletal and smooth muscle, stem cells, regeneration, disease or therapeutics. Novel applications for cell and tissue engineering including cell therapy, tissue models and disease pathology modeling are introduced. This book also deals with the differentiation/de-differentiation process of vascular smooth muscle cells in health and disease. Furthermore, natural products to reverse metabolic syndromes are descriptively reviewed. These chapters can be interesting for graduate students, teachers, physicians, executives and researchers in the field of molecular biology and regenerative medicine.

The Guide to Investigation of Mouse Pregnancy
The Guide to Investigation of Mouse Pregnancy

Author: B. Anne Croy

Publisher: Academic Press

Published: 2013-12-09

Total Pages: 829

ISBN-13: 0123947944

DOWNLOAD EBOOK

The Guide to Investigation of Mouse Pregnancy is the first publication to cover the mouse placenta or the angiogenic tree the mother develops to support the placenta. This much-needed resource covers monitoring of the cardiovascular system, gestational programming of chronic adult disease, epigenetic regulation, gene imprinting, and stem cells. Offering detailed and integrated information on how drugs, biologics, stress, and manipulations impact pregnancy in the mouse model, this reference highlights techniques used to analyze mouse pregnancy. Joining the ranks of much referenced mouse resources, The Guide to Investigation of Mouse Pregnancy is the only manual providing needed content on pregnancy in animal models for translational medicine and research. - Provides instruction on how to collect pre-clinical data on pregnancy in mouse models for eventual use in human applications - Describes the angiogenic tree the mother's uterus develops to support pregnancy and the monitoring of pregnancy-induced cardiovascular changes - Educates readers on placental cell lineages, decidual development including immune cells, epigenetic regulation, gene imprinting, stem cells, birth and lactation - Discusses how stress, environmental toxicants and other manipulations impact upon placental function and pregnancy success

Inflammation and Cardiac Diseases
Inflammation and Cardiac Diseases

Author: Giora Z. Feuerstein

Publisher: Springer Science & Business Media

Published: 2003-08-25

Total Pages: 444

ISBN-13: 9783764367251

DOWNLOAD EBOOK

Heart failure research is a most active area of research in academic, industrial and government-sponsored research and receives intense clinical attention. The recent recognition that inflammation is a risk factor and prognostic factor for heart disease has laid ground for preventive medicine and even anti-infective strategies in prevention and treatment of heart failure. Provides a new perspective on the etiology of cardiac failure Covers the latest developments Discusses future treatments for heart failure Ideal for researchers and clinicians