Measuring Biological Impacts of Nanomaterials

Measuring Biological Impacts of Nanomaterials

Author: Joachim Wegener

Publisher: Springer

Published: 2016-02-02

Total Pages: 221

ISBN-13: 3319248235

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This book reviews several aspects of the biological response to nanoscale particles on a molecular and cellular level. Nanoscale materials and nanoscale particles in particular have interesting properties and beneficial applications. While they thus have entered our daily lifes on many different levels (from electronics, over textiles, packaging or surface modifications, to biomedical applications), general rules describing their interaction with biological structures and biological matter are still difficult to derive. The existing literature suggests a variety of interaction schemes between nanoparticles and biological objects, not dispelling the public concerns about possible health effects and harmful properties. A systematic approach to the problem is needed and timely. This book specifically emphasizes bioanalytical problems starting from the characterization of the nanomaterials to the pitfalls and potential artifacts of state-of-the-art cytotoxicity assays that are frequently used to study harmful effects on cells. It also highlights the application of label-free bioanalytical techniques that can potentially complement the present approaches and hence provide new perspectives on this highly discussed cutting-edge field of research and public concern.


Environmental and Biochemical Toxicology

Environmental and Biochemical Toxicology

Author: Jürgen Gailer

Publisher: Walter de Gruyter GmbH & Co KG

Published: 2022-06-21

Total Pages: 424

ISBN-13: 3110626349

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This text coherently links biochemical fundamentals and mechanisms with economic and societal problems of environmental pollution. It addresses interdisciplinary topics such as regulatory problems, sampling and pollutant quantifi cation, model organisms and provides a philosophical perspective on the toxin load on a variety of organisms, including humans in the environment in the Anthropocene. Case studies and exercises illustrate current issues and discuss future aspects.


Label-free and Multi-parametric Monitoring of Cell-based Assays with Substrate-embedded Sensors

Label-free and Multi-parametric Monitoring of Cell-based Assays with Substrate-embedded Sensors

Author: Maximilian Oberleitner

Publisher: Springer

Published: 2017-09-26

Total Pages: 391

ISBN-13: 331945384X

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This thesis describes novel substrate embedded physical sensors that can be used to monitor different types of cell-based assays non-invasively and label-free. The sensors described provide integrative information of the cells under study with an adaptable time resolution (ranging from milliseconds to days). This information about the dynamic cell response to chemical, physical or biological stimuli defines a new paradigm in fundamental biomedical research. The author, Maximilian Oberleitner, describes approaches in which the cells are directly grown on different sensor surfaces (gold-film electrodes, shear wave resonators or dye-doped polymer films). This approach, with the reacting cells in particularly close proximity and contact with the sensor surface, is key to a remarkable sensitivity, opening the way for a variety of new applications. This thesis not only introduces the fundamentals of each approach, but it also describes in great detail the design principles and elucidates the boundary conditions of the new sensors.


Handbook of Polymers in Medicine

Handbook of Polymers in Medicine

Author: Masoud Mozafari

Publisher: Woodhead Publishing

Published: 2023-08-30

Total Pages: 802

ISBN-13: 0128237988

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Handbook of Polymers in Medicine combines core concepts and advanced research on polymers, providing a better understanding of this class of materials in medicine. The book covers all aspects of medical polymers from characteristics and biocompatibility, to the diverse array of applications in medicine. Chapters cover an introduction to polymers in medicine and the challenges associated with biocompatibility in human tissue, polyurethane and supramolecular polymers and their specific applications in medicine, from tissue regeneration to orthopedic surgery and cancer therapeutics. This book offers an interdisciplinary approach that will appeal to researchers in a range of disciplines, including biomedical engineering, materials science, chemistry, pharmacology and translational medicine. The book will also make a useful reference for clinicians and those in medical fields who are interested in materials for medical applications, as well as R&D groups involved in medical device design. - Systematically covers individual polymer classes, from characteristics and biocompatibility to applications in biomedicine - Covers a broad range of applications in medicine, such as cardiac tissue engineering, targeted drug delivery, dentistry, and more - Provides an interdisciplinary review of polymers in medicine, allowing advanced students and experienced researchers in a range of biomedical and clinical fields to learn more about this fast-evolving area


Environmental and Human Health Impacts of Nanotechnology

Environmental and Human Health Impacts of Nanotechnology

Author: Jamie R. Lead

Publisher: John Wiley & Sons

Published: 2009-07-30

Total Pages: 456

ISBN-13: 9781444307498

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An increased understanding of the environmental and human healthimpacts of engineered nanoparticles is essential for theresponsible development of nanotechnology and appropriateevidence-based policy and guidelines for risk assessment.Presenting the latest advances in the field from a variety ofscientific disciplines, this book offers a comprehensive overviewof this challenging, inter-disciplinary research area. Topics covered include: The properties, preparation and applications ofnanomaterials Characterization and analysis of manufacturednanoparticles The fate and behaviour of nanomaterials in aquatic, terrestrialand atmospheric environments Ecotoxicology and human toxicology of manufacturednanoparticles Occupational health and exposure of nanomaterials Risk assessment and global regulatory and policy responses Understanding the behaviour and impacts of nanotechnology in theenvironment and in human health is a daunting task and manyquestions remain to be answered. Environmental and Human HealthImpacts of Nanotechnology will serve as a valuable resource foracademic researchers in nanoscience and nanotechnology,environmental science, materials science and biology, as well asfor scientists in industry, regulators and policy makers.


Adverse Effects of Engineered Nanomaterials

Adverse Effects of Engineered Nanomaterials

Author: Bengt Fadeel

Publisher: Academic Press

Published: 2017-02-14

Total Pages: 488

ISBN-13: 0128094907

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Adverse Effects of Engineered Nanomaterials: Exposure, Toxicology, and Impact on Human Health, Second Edition, provides a systematic evaluation of representative engineered nanomaterials (ENM) of high volume production and their high economic importance. Each class of nanomaterials discussed includes information on what scientists, industry, regulatory agencies, and the general public need to know about nanosafety. Written by leading international experts in nanotoxicology and nanomedicine, this book gives a comprehensive view of the health impact of ENM, focusing on their potential adverse effects in exposed workers, consumers, and patients. All chapters have been updated with new sections on the endocrine system and other organ systems. In addition, other newly added sections include introductory chapters on the physio-chemical characterization of nanomaterials and interactions between nanomaterials and biological systems, as well as a new chapter that explores risk assessment and management of nanomaterials. This book fills an important need in terms of bridging the gap between experimental findings and human exposure to ENM, also detailing the clinical and pathological consequences of such exposure in the human population. - Uses a schematic, non-exhaustive approach to summarizes the most important research data in this field - Discusses the health implications of experimental data in nanotoxicology - Presents a completely revised edition that focuses on the human health impacts of engineered nanomaterials, including many organ-specific chapters


Nanoscale Fabrication, Optimization, Scale-up and Biological Aspects of Pharmaceutical Nanotechnology

Nanoscale Fabrication, Optimization, Scale-up and Biological Aspects of Pharmaceutical Nanotechnology

Author: Alexandru Mihai Grumezescu

Publisher: William Andrew

Published: 2017-12-11

Total Pages: 704

ISBN-13: 0128136308

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Nanoscale Fabrication, Optimization, Scale-up and Biological Aspects of Pharmaceutical Nanotechnology focuses on the fabrication, optimization, scale-up and biological aspects of pharmaceutical nanotechnology. In particular, the following aspects of nanoparticle preparation methods are discussed: the need for less toxic reagents, simplification of the procedure to allow economic scale-up, and optimization to improve yield and entrapment efficiency. Written by a diverse range of international researchers, the chapters examine characterization and manufacturing of nanomaterials for pharmaceutical applications. Regulatory and policy aspects are also discussed. This book is a valuable reference resource for researchers in both academia and the pharmaceutical industry who want to learn more about how nanomaterials can best be utilized. - Shows how nanomanufacturing techniques can help to create more effective, cheaper pharmaceutical products - Explores how nanofabrication techniques developed in the lab have been translated to commercial applications in recent years - Explains safety and regulatory aspects of the use of nanomanufacturing processes in the pharmaceutical industry


Nanotechnology

Nanotechnology

Author: Jo Anne Shatkin

Publisher: CRC Press

Published: 2017-12-19

Total Pages: 287

ISBN-13: 1351832689

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Should you adopt nanotechnology? If you have already adopted it, what do you need to know? What are the risks? Nanomaterials and nanotechnologies are revolutionizing the ways we treat disease, produce energy, manufacture products, and attend to our daily wants and needs. To continue to capture the promise of these transformative products, however, we need to ask critical questions about the broader impacts of nanotechnology on society and the environment. Exploring these questions, the second edition of Nanotechnology: Health and Environmental Risks gives you the latest tools to understand the risks of nanotechnology and make better decisions about using it. Examining the state of the science, the book discusses what is known, and what still needs to be understood, about nanotechnology risk. It looks at the uses of nanotechnology for energy, industry, medicine, technology, and consumer applications and explains how to determine whether there is risk—even when there is little reliable evidence—and how to manage it. Contributors cover a wide range of topics, including: Current concerns, among them perceived risks and the challenges of evaluating emerging technology A historical perspective on product safety and chemicals policy The importance of being proactive about identifying and managing health and environmental risks during product development How the concepts of sustainability and life cycle assessment can guide nanotechnology product development Methods for evaluating nanotechnology risks, including screening approaches and research How to manage risk when working with nanoscale materials at the research stage and in occupational environments What international organizations are doing to address risk issues How risk assessment can inform environmental decision making Written in easy-to-understand language, without sacrificing complexity or scientific accuracy, this book offers a wide-angle view of nanotechnology and risk. Supplying cutting-edge approaches and insight, it explains what types of risks could exist and what you can do to address them. What’s New in This Edition Updates throughout, reflecting advances in the field, new literature, and policy developments A new chapter on nanotechnology risk communication, including insights into risk perceptions and the mental models people use to evaluate technological risks An emphasis on developing nanotechnology products that are sustainable in the long term Advances in the understanding of nanomaterials toxicity Cutting-edge research on occupational exposure to nanoparticles Changes in the international landscape of organizations working on the environmental, health, and safety aspects of nanotechnologies