Links Between Recombination and Replication

Links Between Recombination and Replication

Author: Proceedings of the National Academy of Sciences

Publisher: National Academies Press

Published: 2002-09-18

Total Pages: 303

ISBN-13: 030907424X

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There has been a sea change in how we view genetic recombination. When germ cells are produced in higher organisms, genetic recombination assures the proper segregation of like chromosomes. In the course of that process, called meiosis, recombination not only assures segregation of one chromosome of each type to progeny germ cells, but also further shuffles the genetic deck, contributing to the unique inheritance of individuals. In a nutshell, that is the classical view of recombination. We have also known for many years that in bacteria recombination plays a role in horizontal gene transfer and in replication itself, the latter by establishing some of the replication forks that are the structural scaffolds for copying DNA. In recent years, however, we have become increasingly aware that replication, which normally starts without any help from recombination, is a vulnerable process that frequently leads to broken DNA. The enzymes of recombination play a vital role in the repair of those breaks. The recombination enzymes can function via several different pathways that mediate the repair of breaks, as well as restoration of replication forks that are stalled by other kinds of damage to DNA. Thus, to the classical view of recombination as an engine of inheritance we must add the view of recombination as a vital housekeeping function that repairs breaks suffered in the course of replication. We have also known for many years that genomic instability--including mutations, chromosomal rearrangements, and aneuploidy--is a hallmark of cancer cells. Although genomic instability has many contributing causes, including faulty replication, there are many indications that recombination, faulty or not, contributes to genome instability and cancer as well. The (Nas colloquium) Links Between Recombination and Replication: Vital Roles of Recombination was convened to broaden awareness of this evolving area of research. Papers generated by this colloquium are published here. To encourage the desired interactions of specialists, we invited some contributions that deal only with recombination or replication in addition to contributions on the central thesis of functional links between recombination and replication. To aid the nonspecialist and specialist alike, we open the set of papers with a historical overview by Michael Cox and we close the set with a commentary on the meeting and the field by Andrei Kuzminov.


Mechanisms of DNA Recombination and Genome Rearrangements: Methods to Study Homologous Recombination

Mechanisms of DNA Recombination and Genome Rearrangements: Methods to Study Homologous Recombination

Author:

Publisher: Academic Press

Published: 2018-02-17

Total Pages: 610

ISBN-13: 0128144300

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Mechanisms of DNA Recombination and Genome Rearrangements: Methods to Study Homologous Recombination, Volume 600, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Homologous genetic recombination remains the most enigmatic process in DNA metabolism. The molecular machines of recombination preserve the integrity of the genetic material in all organisms and generate genetic diversity in evolution. The same molecular machines that support genetic integrity by orchestrating accurate repair of the most deleterious DNA lesions, however, also promote survival of cancerous cells and emergence of radiation and chemotherapy resistance. This two-volume set offers a comprehensive set of cutting edge methods to study various aspects of homologous recombination and cellular processes that utilize the enzymatic machinery of recombination The chapters are written by the leading researches and cover a broad range of topics from the basic molecular mechanisms of recombinational proteins and enzymes to emerging cellular techniques and drug discovery efforts. - Contributions by the leading experts in the field of DNA repair, recombination, replication and genome stability - Documents cutting edge methods


Molecular Life Sciences

Molecular Life Sciences

Author: Robert D. Wells

Publisher: Springer

Published: 2018-01-12

Total Pages: 0

ISBN-13: 9781461415299

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Molecular Life Sciences: An Encyclopedic Reference will focus on understanding biological phenomena at the level of molecules and their interactions that govern life processes. The work will include articles on genes and genomes, protein structure and function, systems biology using genomics and proteomics as the focus, molecular aspects of cell structure and function, unifying concepts and theories from biology, chemistry, mathematics and physics that are essential for understanding the molecular life sciences (including teaching perspectives and assessment tools), and basic aspects of the various experimental approaches that are used in the Molecular Life Sciences.


Genetics for Surgeons

Genetics for Surgeons

Author: Patrick John Morrison

Publisher: Remedica

Published: 2005

Total Pages: 237

ISBN-13: 1901346692

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Morrison (human genetics, University of Ulster, UK) and Spence (biomedical science, University of Ulster, UK) offer an accessible reference on the genetic disorders that surgeons can expect to meet in general surgical practice. Written in non-technical language, with a glossary, list of abbreviations, and color and b&w photos and medical images, the book supplies an introduction to the nomenclature and technology of molecular biology, and will be a useful starting point for those who wish to extend their knowledge. Annotation :2005 Book News, Inc., Portland, OR (booknews.com).


The origin of life is rhythmic repair or Macrocosmic rhythms created life

The origin of life is rhythmic repair or Macrocosmic rhythms created life

Author: Roland Frey

Publisher: tredition

Published: 2023-03-06

Total Pages: 496

ISBN-13: 3347888065

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Life on earth arose through the creative interplay of prebiotic conditions on earth and the everlasting reliable macrocosmic changes of light and darkness. The first life molecules were confronted with the Earth's two-faced environment manifesting itself as a rhythm of a damaging light phase (day) and a harmless low light dark phase (night) produced by the apparent celestial movements within the earth-moon-sun system. It required two mutually complementing molecule types: ribonucleic acids and peptides, which had to adapt jointly to that fundamental duality in order to achieve a 'duration across change'. Both combined into a helically intertwined ribonucleopeptide filament as the initial molecular structure of life on earth. The predictable alternation of a damaging (UV irradiation, high-energy sun light) and a non-damaging (low-energy moon light) phase lead to the inclusion of rhythmic repair and timing in molecular life from begin on. The ribonucleopeptide filament responded to the dual qualities of its environment by behaving like an 'oscilloid'. Rhythmically alternating contraction to prevent damage during daytime and expansion to allow self-sustained repair during nighttime initiated the oscillation of the primordial biological timer as a molecular reflection of the macrocosmic time on Earth impacted by the light/dark rhythm. Macrocosmic time is both circular, because days, months and years consist of recurring cycles of light and darkness, and linear, because successive days, months and years are not identical repeats of the preceding ones and follow each other in a row. Corresponding to this yin/yang structure of macrocosmic time, biological time is also cyclical and linear at the same time. Under this perspective, life arose as an earth-bound molecular pattern instructed by celestial rhythms. Interestingly, there exists a correspondence to the dual, mutually complementing molecular basis of life in ancient Chinese mythology. A helically intertwined ribonuclopeptide filament represents an equivalent, a living reflection, of the T'ai chi symbol with its mutually complementing, inseparable black and white components that illustrate the fundamental duality of darkness and light or night and day on Earth. Yang and Yin, and Ch'ien and K'un, constitute the basic duality of the yin/yang philosophy and the ancient Chinese Book of Changes, the I Ging, respectively. Fu-hsi and Nü-kua, the personified versions of this basic duality, are characterised by their helically intertwining snake- or dragon-like lower bodies. Together, they are linking Earth to Heaven.


Human Herpesviruses

Human Herpesviruses

Author: Ann Arvin

Publisher: Cambridge University Press

Published: 2007-08-16

Total Pages: 1325

ISBN-13: 1139461648

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This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.