Come along on an amazing journey with Lilly as she embarks on her first grand adventure. With vibrant and captivating images, this book will transport you to a magical world and encourage young minds to explore and learn. Enjoy the amazing illustrations that unfold throughout the story - the illustrator's imagination fully encapsulates the author's intent and combines to make a fully immersive adventure.
Mr. Slinger has big news. He's getting married. Married! Lilly has big plans. She's going to be the flower girl. (Lilly has always wanted to be a flower girl. Even more than a surgeon or a diva or a hairdresser.) But what's the biggest, the best, the most perfect thing of all? You're invited to the wedding -- so start reading!
A beautifully illustrated look inside of Indiana University Bloomington’s renowned library of rare books, manuscripts, and related oddities. What do locks of Edgar Allan Poe’s hair, Sylvia Plath’s attractive handmade paper dolls, John Ford’s Oscars, and Ian Fleming’s James Bond 007 cigars have in common? They are just a few of the fascinating objects found in the world-famous Lilly Library, located on the campus of Indiana University Bloomington. In this beautifully illustrated A-to-Z volume, Darlene J. Sadlier journeys through the library’s wide-ranging collections to highlight dozens of intriguing items and the archives of which they are a part. Read about life and death masks of John Keats, Abraham Lincoln, and Theodore Dreiser; Walt Whitman’s last pencil; and vintage board games, mechanical puzzles, and even comic books. Among the more peculiar items are a pair of elk teeth and an eerily realistic wall-mount bust of Boris Karloff. Sadlier writes engagingly about the Lilly Library’s major historical collections, which include Civil War diaries and a panopticon of the war called the Myriopticon; War of 1812 payment receipts to spies; and the World War II letters and V-mail of journalist Ernie Pyle. This copiously illustrated, entertaining, and educational book will inspire you to take your own journey and discover for yourself the wonders of the Lilly Library.
This volume covers all aspects of the antibiotic discovery and development process through Phase II/III. The contributors, a group of highly experienced individuals in both academics and industry, include chapters on the need for new antibiotic compounds, strategies for screening for new antibiotics, sources of novel synthetic and natural antibiotics, discovery phases of lead development and optimization, and candidate compound nominations into development. Beyond discovery , the handbook will cover all of the studies to prepare for IND submission: Phase I (safety and dose ranging), progression to Phase II (efficacy), and Phase III (capturing desired initial indications). This book walks the reader through all aspects of the process, which has never been done before in a single reference. With the rise of antibiotic resistance and the increasing view that a crisis may be looming in infectious diseases, there are strong signs of renewed emphasis in antibiotic research. The purpose of the handbook is to offer a detailed overview of all aspects of the problem posed by antibiotic discovery and development.
Despite her parents' struggles with addiction, Lilly Dancyger always thought of her childhood as a happy one. But what happens when a journalist interrogates her own rosy memories to reveal the instability around the edges? Dancyger's father, Joe Schactman, was part of the iconic 1980s East Village art scene. He created provocative sculptures out of found materials like animal bones, human hair, and broken glass, and brought his young daughter into his gritty, iconoclastic world. She idolized him—despite the escalating heroin addiction that sometimes overshadowed his creative passion. When Schactman died suddenly, just as Dancyger was entering adolescence, she went into her own self-destructive spiral, raging against a world that had taken her father away. As an adult, Dancyger began to question the mythology she'd created about her father—the brilliant artist, struck down in his prime. Using his sculptures, paintings, and prints as a guide, Dancyger sought out the characters from his world who could help her decode the language of her father's work to find the truth of who he really was.
In this comprehensive two-volume resource on the topic senior lead generation medicinal chemists present a coherent view of the current methods and strategies in industrial and academic lead generation. This is the first book to combine both standard and innovative approaches in comparable breadth and depth, including several recent successful lead generation case studies published here for the first time. Beginning with a general discussion of the underlying principles and strategies, individual lead generation approaches are described in detail, highlighting their strengths and weaknesses, along with all relevant bordering disciplines like e.g. target identification and validation, predictive methods, molecular recognition or lead quality matrices. Novel lead generation approaches for challenging targets like DNA-encoded library screening or chemical biology approaches are treated here side by side with established methods as high throughput and affinity screening, knowledge- or fragment-based lead generation, and collaborative approaches. Within the entire book, a very strong focus is given to highlight the application of the presented methods, so that the reader will be able to learn from real life examples. The final part of the book presents several lead generation case studies taken from different therapeutic fields, including diabetes, cardiovascular and respiratory diseases, neuroscience, infection and tropical diseases. The result is a prime knowledge resource for medicinal chemists and for every scientist involved in lead generation.
Lilly Marchantel entertains her client-a vampire-for a night of paid passion and dies. Or does she? Her madam, the famous Lulu White of Mahogany Hall, throws a lavish funeral for the girl and buries her in St. Louis 1 cemetery. During the chaos in the wake of Hurricane Katrina, Enforcer angel Sullivan is sent to the cemetery to verify reports of two rogue vampires. What could happen if Sullivan loses his powers? How much trouble can an angel get into in New Orleans? "Lilly's Angel" tells the story of Lilly's discovery of a whole new world with her friends Baron the Cat and the skull she talks to as the pissed off and horny Sullivan struggles against the changes he is experiencing.
The global center of gravity in life sciences innovation is rapidly shifting to emerging economies. In The New Players in Life Science Innovation, Tomasz Mroczkowski explains how China and other new economic powers are rapidly gaining leadership positions, and thoroughly assesses the implications. Mroczkowski discusses the sophisticated innovation strategies and reforms these nations have implemented: approaches that don't rely on market forces alone, and are achieving remarkable success. Next, he previews the emerging global "bio-economy," in which life science discoveries will be applied pervasively in markets ranging from health to fuels. As R&D in the West becomes increasingly costly, Mroczkowski introduces new options for partnering with new players in the field. He thoroughly covers the globalization of clinical trials, showing how it offers opportunities that go far beyond cost reduction, and assessing the unique challenges it presents. Offering examples from China to Dubai to India, he carefully assesses the business models driving today's newest centers of innovation. Readers will find up-to-date coverage of bioparks, technology zones, and emerging clusters, and realistic assessments of global R&D collaboration strategies such as those of Eli Lilly, Merck, Novartis, and IBM. With innovation-driven industries increasingly dominating the global economy, this book's insights are indispensable for every R&D decision-maker and investor.
Volume 40 contains state-of-the-art, comprehensive reviews about applied microbiology, biotechnology, and microbial ecology, including a two-part review on "Challenges in Commercial Biotechnology" by Dr. Ales Prokopand a review on microbial cellulases.
