The Last Utopia

The Last Utopia

Author: Samuel Moyn

Publisher: Harvard University Press

Published: 2012-03-05

Total Pages: 346

ISBN-13: 0674256522

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Human rights offer a vision of international justice that today’s idealistic millions hold dear. Yet the very concept on which the movement is based became familiar only a few decades ago when it profoundly reshaped our hopes for an improved humanity. In this pioneering book, Samuel Moyn elevates that extraordinary transformation to center stage and asks what it reveals about the ideal’s troubled present and uncertain future. For some, human rights stretch back to the dawn of Western civilization, the age of the American and French Revolutions, or the post–World War II moment when the Universal Declaration of Human Rights was framed. Revisiting these episodes in a dramatic tour of humanity’s moral history, The Last Utopia shows that it was in the decade after 1968 that human rights began to make sense to broad communities of people as the proper cause of justice. Across eastern and western Europe, as well as throughout the United States and Latin America, human rights crystallized in a few short years as social activism and political rhetoric moved it from the hallways of the United Nations to the global forefront. It was on the ruins of earlier political utopias, Moyn argues, that human rights achieved contemporary prominence. The morality of individual rights substituted for the soiled political dreams of revolutionary communism and nationalism as international law became an alternative to popular struggle and bloody violence. But as the ideal of human rights enters into rival political agendas, it requires more vigilance and scrutiny than when it became the watchword of our hopes.


Cancer Evolution

Cancer Evolution

Author: Charles Swanton

Publisher: Perspectives Cshl

Published: 2017

Total Pages: 350

ISBN-13: 9781621821434

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Tumor progression is driven by mutations that confer growth advantages to different subpopulations of cancer cells. As a tumor grows, these subpopulations expand, accumulate new mutations, and are subjected to selective pressures from the environment, including anticancer interventions. This process, termed clonal evolution, can lead to the emergence of therapy-resistant tumors and poses a major challenge for cancer eradication efforts. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine examines cancer progression as an evolutionary process and explores how this way of looking at cancer may lead to more effective strategies for managing and treating it. The contributors review efforts to characterize the subclonal architecture and dynamics of tumors, understand the roles of chromosomal instability, driver mutations, and mutation order, and determine how cancer cells respond to selective pressures imposed by anticancer agents, immune cells, and other components of the tumor microenvironment. They compare cancer evolution to organismal evolution and describe how ecological theories and mathematical models are being used to understand the complex dynamics between a tumor and its microenvironment during cancer progression. The authors also discuss improved methods to monitor tumor evolution (e.g., liquid biopsies) and the development of more effective strategies for managing and treating cancers (e.g., immunotherapies). This volume will therefore serve as a vital reference for all cancer biologists as well as anyone seeking to improve clinical outcomes for patients with cancer.


The Italian Renaissance in the German Historical Imagination, 1860–1930

The Italian Renaissance in the German Historical Imagination, 1860–1930

Author: Martin A. Ruehl

Publisher: Cambridge University Press

Published: 2015-10-15

Total Pages: 343

ISBN-13: 1316298655

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Towards the end of the nineteenth century, Germany's bourgeois elites became enthralled by the civilization of Renaissance Italy. As their own country entered a phase of critical socioeconomic changes, German historians and writers reinvented the Italian Renaissance as the onset of a heroic modernity: a glorious dawn that ushered in an age of secular individualism, imbued with ruthless vitality and a neo-pagan zest for beauty. The Italian Renaissance in the German Historical Imagination is the first comprehensive account of the debates that shaped the German idea of the Renaissance in the seven decades following Jacob Burckhardt's seminal study of 1860. Based on a wealth of archival material and enhanced by more than one hundred illustrations, it provides a new perspective on the historical thought of Imperial and Weimar Germany, and the formation of a concept that is still with us today.


European Clocks in the J. Paul Getty Museum

European Clocks in the J. Paul Getty Museum

Author: Gillian Wilson

Publisher: Getty Publications

Published: 2013-08-15

Total Pages: 225

ISBN-13: 0892362545

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Among the finest examples of European craftsmanship are the clocks produced for the luxury trade in the eighteenth century. The J. Paul Getty Museum is fortunate to have in its decorative arts collection twenty clocks dating from around 1680 to 1798: eighteen produced in France and two in Germany. They demonstrate the extraordinary workmanship that went into both the design and execution of the cases and the intricate movements by which the clocks operated. In this handsome volume, each clock is pictured and discussed in detail, and each movement diagrammed and described. In addition, biographies of the clockmakers and enamelers are included, as are indexes of the names of the makers, previous owners, and locations.