Ion Channels of Vascular Smooth Muscle Cells and Endothelial Cells
Ion Channels of Vascular Smooth Muscle Cells and Endothelial Cells

Author: International Society for Heart Research. Meeting

Publisher:

Published: 1991

Total Pages: 402

ISBN-13:

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This authoritative new book focuses on the electrophysiology and ion channels of vascular smooth muscle and vascular endothelial cells. Presenting current information from leading researchers around the world, the book details the importance of these two cell types in the understanding of vascular pathophysiology, the treatment of disease, and the regulation and distribution of blood flow.

Mechanisms of Vascular Disease
Mechanisms of Vascular Disease

Author: Robert Fitridge

Publisher: University of Adelaide Press

Published: 2011

Total Pages: 589

ISBN-13: 1922064009

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New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.

Ion Channels in Vascular and Corpus Cavernosum Smooth Muscle [microform]
Ion Channels in Vascular and Corpus Cavernosum Smooth Muscle [microform]

Author: Tom Karkanis

Publisher: National Library of Canada = Bibliothèque nationale du Canada

Published: 2002

Total Pages: 166

ISBN-13: 9780612770966

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The present studies were undertaken to investigate plasticity of ion channel expression and function in vascular smooth muscle. Using patch-clamp electrophysiology and Ca2+ fluorescence techniques, we investigated receptor-signalling and distinct ion channel activity in proliferative and contractile HITB5 cells, a human vascular smooth muscle cell (SMC) clone with the ability to bi-directionally switch phenotype. Histamine increased intracellular Ca2+ and activated large-conductance Ca2+-activated K+ (BKCa) channels in both phenotypes. Cell-attached patch recording revealed a unitary BKCa channel conductance of 240 pS. Furthermore, Ca2+-activated Cl- (Cl Ca) currents were recorded only in contractile cells, indicating differential expression or regulation of ion channels with phenotypic conversion.

Signal Transduction and Smooth Muscle
Signal Transduction and Smooth Muscle

Author: Mohamed Trebak

Publisher: CRC Press

Published: 2018-08-06

Total Pages: 353

ISBN-13: 1351650610

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All hollow organs, such as blood vessels, the gastrointestinal tract, airways, male and female reproductive systems, and the urinary bladder are primarily composed of smooth muscle. Such organs regulate flow, propulsion and mixing of luminal contents and storage by the contraction and relaxation of smooth muscle cells. Smooth muscle cells respond to numerous inputs, including pressure, shear stress, intrinsic and extrinsic innervation, hormones and other circulating molecules, as well as autocrine and paracrine factors. This book is a review of smooth muscle cell regulation in the cardiovascular, reproductive, GI, and other organ systems with emphasis on calcium and receptor signaling. Key selling features: Focuses on smooth muscles of different types Describes ion channel signaling mechanisms Reviews calcium and receptor signaling Includes novel, cutting-edge methodologies Summarizes studies of mice with genetically encoding sensors in smooth muscle Chapter 9 of this book is freely available as a downloadable Open Access PDF under a CC-BY 4.0 license. https://s3-us-west-2.amazonaws.com/tandfbis/rt-files/docs/Open+Access+Chapters/9781498774222_oachapter9.pdf

Vascular Ion Channels in Physiology and Disease
Vascular Ion Channels in Physiology and Disease

Author: Irena Levitan, PhD

Publisher: Springer

Published: 2016-07-06

Total Pages: 439

ISBN-13: 3319296353

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Ion channels are the major class of membrane proteins responsible for rapid and regulated transport of ions across biological membranes and for the generation and propagation of electrical signals in the brain, heart, and skeletal and vascular tissues. Ion channels are also known to play critical roles in regulation of cell proliferation, insulin secretion and intracellular signaling in a variety of cell types. This book focuses on the roles of ion channels in vascular tissues under normal and pathological conditions. Vascular abnormalities are known to underlie a plethora of severe pathological conditions, such as atherosclerosis, systemic and pulmonary hypertension, coronary or cerebral vasospasm, and diabetes. In addition, misregulated angiogenesis is one of the major contributors to the development of tumors. Therefore, it is clearly imperative to obtain a better understanding of the molecular mechanisms that contribute to vascular disorders. This book will be the first comprehensive assembly of assays to present the studies that have been done during the last decade to elucidate the roles of ion channels in different vascular diseases.