Microfluidics deals with fluids flowing in miniaturized systems, and has practical applications in the pharmaceutical, biomedical and chemical engineering fields. This text provides an introduction to this emerging discipline.
Laboratory Methods in Microfluidics features a range of lab methods and techniques necessary to fully understand microfluidic technology applications. Microfluidics deals with the manipulation of small volumes of fluids at sub-millimeter scale domain channels. This exciting new field is becoming an increasingly popular subject both for research and education in various disciplines of science, including chemistry, chemical engineering and environmental science. The unique properties of microfluidic technologies, such as rapid sample processing and precise control of fluids in assay have made them attractive candidates to replace traditional experimental approaches. Practical for students, instructors, and researchers, this book provides a much-needed, comprehensive new laboratory reference in this rapidly growing and exciting new field of research. - Provides a number of detailed methods and instructions for experiments in microfluidics - Features an appendix that highlights several standard laboratory techniques, including reagent preparation plus a list of materials vendors for quick reference - Authored by a microfluidics expert with nearly a decade of research on the subject
The first book offering a global overview of fundamental microfluidics and the wide range of possible applications, for example, in chemistry, biology, and biomedical science. As such, it summarizes recent progress in microfluidics, including its origin and development, the theoretical fundamentals, and fabrication techniques for microfluidic devices. The book also comprehensively covers the fluid mechanics, physics and chemistry as well as applications in such different fields as detection and synthesis of inorganic and organic materials. A useful reference for non-specialists and a basic guideline for research scientists and technicians already active in this field or intending to work in microfluidics.
Microfluidics is a young and rapidly expanding scientific discipline, which deals with fluids and solutions in miniaturized systems, the so-called lab-on-a-chip systems. It has applications in chemical engineering, pharmaceutics, biotechnology and medicine. As the lab-on-a-chip systems grow in complexity, a proper theoretical understanding becomes increasingly important. The basic idea of the book is to provide a self-contained formulation of the theoretical framework of microfluidics, and at the same time give physical motivation and examples from lab-on-a-chip technology. After three chapters introducing microfluidics, the governing equations for mass, momentum and energy, and some basic flow solutions, the following 14 chapters treat hydraulic resistance/compliance, diffusion/dispersion, time-dependent flow, capillarity, electro- and magneto-hydrodynamics, thermal transport, two-phase flow, complex flow patterns and acousto-fluidics, as well as the new fields of opto- and nano-fluidics. Throughout the book simple models with analytical solutions are presented to provide the student with a thorough physical understanding of order of magnitudes and various selected microfluidic phenomena and devices. The book grew out of a set of well-tested lecture notes. It is with its many pedagogical exercises designed as a textbook for an advanced undergraduate or first-year graduate course. It is also well suited for self-study.
Edited by two leaders, this book has drawn together expertise from around the globe to form a unified, cohesive resource for the droplet microfluidics community. Starting with the basic theory of droplet microfluidics before introducing its use as a tool, the reader is treated to chapters on important techniques, including robust passive and active droplet manipulations and applications such as single cell analysis, which is key for drug discovery. This book is a go-to resource for the community yearning to adopt and promote droplet microfluidics into different applications.
Microfluidics is a microtechnological field dealing with the precise transport of fluids (liquids or gases) in small amounts (e.g. microliters, nanoliters or even picoliters). This book provides a useful introduction into this burgeoning field, and a specific application of microfluidics is presented. It also gives a survey of microfluidics.
Lately, there has been a growing interest in exploiting the benefits of the ICs for areas outside of the traditional application spaces. One noteable area is found in biology Bioanalytical instruments have been miniaturized on ICs to study various biophenomena or to actuate biosystems. These biolab-on-IC systems utilize the IC to facilitate faster, repeatable, and standardized biological experiments at low cost with a small volume of biological sample. The research activities in this field are expected to enjoy substantial growth in the foreseeable future. BioCMOS Technologies reviews these exciting recent efforts in joining CMOS technology with biology.
Microfluidics: Modeling, Mechanics and Mathematics, Second Edition provides a practical, lab-based approach to nano- and microfluidics, including a wealth of practical techniques, protocols and experiments ready to be put into practice in both research and industrial settings. This practical approach is ideally suited to researchers and R&D staff in industry. Additionally, the interdisciplinary approach to the science of nano- and microfluidics enables readers from a range of different academic disciplines to broaden their understanding. Alongside traditional fluid/transport topics, the book contains a wealth of coverage of materials and manufacturing techniques, chemical modification/surface functionalization, biochemical analysis, and the biosensors involved. This fully updated new edition also includes new sections on viscous flows and centrifugal microfluidics, expanding the types of platforms covered to include centrifugal, capillary and electro kinetic platforms. - Provides a practical guide to the successful design and implementation of nano- and microfluidic processes (e.g., biosensing) and equipment (e.g., biosensors, such as diabetes blood glucose sensors) - Provides techniques, experiments and protocols that are ready to be put to use in the lab, or in an academic or industry setting - Presents a collection of 3D-CAD and image files on a companion website
Fully comprehensive introduction to the rapidly emerging area of micro systems technology Transport Phenomena in Micro Systems explores the fundamentals of the new technologies related to Micro-Electro-Mechanical Systems (MEMS). It deals with the behavior, precise control and manipulation of fluids that are geometrically constrained to a small, typically sub-millimeter, scale, such as nl, pl, fl, small size, low energy consumption, effects of the micro domain and heat transfer in the related devices. The author describes in detail and with extensive illustration micro fabrication, channel flow, transport laws, magnetophoresis, micro scale convection and micro sensors and activators, among others. This book spans multidisciplinary fields such as material science and mechanical engineering, engineering, physics, chemistry, microtechnology and biotechnology. Brings together in one collection recent and emerging developments in this fast-growing area of micro systems Covers multidisciplinary fields such as materials science, mechanical engineering, microtechnology and biotechnology, et al Comprehensive coverage of analytical models in microfluidics and MEMS technology Introduces micro fluidics applications include the development of inkjet printheads, micro-propulsion, and micro thermal technologies Presented in a very logical format Supplies readers with problems and solutions
Stories behind essential microfluidic devices, from the inkjet printer to DNA sequencing chip. Hidden from view, microfluidics underlies a variety of devices that are essential to our lives, from inkjet printers to glucometers for the monitoring of diabetes. Microfluidics—which refers to the technology of miniature fluidic devices and the study of fluids at submillimeter levels—is invisible to most of us because it is hidden beneath ingenious user interfaces. In this book, Albert Folch, a leading researcher in microfluidics, describes the development and use of key microfluidic devices. He explains not only the technology but also the efforts, teams, places, and circumstances that enabled these inventions. Folch reports, for example, that the inkjet printer was one of the first microfluidic devices invented, and traces its roots back to nineteenth-century discoveries in the behavior of fluid jets. He also describes how rapid speed microfluidic DNA sequencers have enabled the sequencing of animal, plant, and microbial species genomes; organs on chips facilitate direct tests of drugs on human tissue, leapfrogging over the usual stage of animal testing; at-home pregnancy tests are based on clever microfluidic principles; microfluidics can be used to detect cancer cells in the early stages of metastasis; and the same technology that shoots droplets of ink on paper in inkjet printers enables 3D printers to dispense layers of polymers. Folch tells the stories behind these devices in an engaging style, accessible to nonspecialists. More than 100 color illustrations show readers amazing images of microfluids under the microscope.