International Classification of Rodent Tumors. The Mouse
International Classification of Rodent Tumors. The Mouse

Author: Ulrich Mohr

Publisher: Springer Science & Business Media

Published: 2013-11-21

Total Pages: 487

ISBN-13: 3662079739

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Scientists from both academia and industry in many countries have closely cooperated to arrive at a consensus on the descriptions of all the types of tumour and preneoplastic lesions encountered in laboratory mice. The series of fascicles should provide information and guidelines especially adapted for international use in practical toxicologic pathology. Images showing the typical appearance of the discussed lesions and references to the most recently published papers complete the information presented here.

Respiratory System
Respiratory System

Author: Thomas C. Jones

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 368

ISBN-13: 3642610420

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Approximately ten years have elapsed since the second volume of the International Life Sciences Institute (ILSI) Monographs on Pathology of Laboratory Animals, Respiratory System, was first completed. New in formation of interest to pathologists has developed at a rather remark able pace during these years. Exceptional progress has been made in the routine identification of enzymes and cell products in respiratory cells. A better understanding has developed on the functions of cells of the respiratory tract and of the mechanisms involved in cell metabolism, particularly those involving toxins and carcinogens. Clear concepts have developed concerning the significance of pathologic lesions, particularly in the upper respiratory tract and their relation to human health and risk assessment. Standardized nomenclature has developed significantly dur ing the lO-year period since the first edition and is being utilized on an international basis. This has resulted in significant improvement in com munication of pathologic data to regulatory agencies and in scientific publications worldwide. This monograph series and others sponsored by ILSI have had significant effects on these improved communications and the international acceptance of standardized nomenclature. In this sec ond edition, new formats have been used where more appropriate for the subjects to be covered.

The Laboratory Mouse
The Laboratory Mouse

Author: Hans Hedrich

Publisher: Academic Press

Published: 2012-07-16

Total Pages: 869

ISBN-13: 0123820081

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"Mice have long been recognized as a valuable tool for investigating the genetic and physiological bases of human diseases such as diabetes, infectious disease, cancer, heart disease, and a wide array of neurological disorders. With the advent of transgenic and other genetic engineering technologies, the versatility and usefulness of the mouse as a model in biomedical research has soared. As a result, mouse colonies everywhere are expanding, and scientists who previously focused on other models are turning their attention to the mouse. Revised to reflect advances since the first edition, The Laboratory Mouse, Second Edition continues to be the most accessible reference on the biology and care of the laboratory mouse. This guide presents basic information and common procedures in detail to provide a quick reference source for investigators, technicians, and caretakers in the humane care and use of the mouse in the laboratory setting. Expanded, updated, and now in color, this new edition includes coverage of the biological features, husbandry, management, veterinary care, experimental methodology, and resources applying specifically to the mouse"--Provided by publisher.

International Classification of Rodent Tumours
International Classification of Rodent Tumours

Author: Ulrich Mohr

Publisher:

Published: 1994

Total Pages: 104

ISBN-13: 9789283201274

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This is the seventh in a unique series of fasicles comprising an international classification of rodent tumors which provides information and guidelines for international use in practical toxicologic pathology. In a concise, easy-to-use format, essential information on each lesion is presented with typical micorgraphs selected from both spontaneous and induced lesions. The complete range of organ systems in the rat is covered in the series of 10 fasicles. Fasicle 7 covers the central nervous system, heart, eye, and mesothelium. This classification will harmonize and standardize the nomenclature and diagnostic criteria to be used worldwide for regulatory purposes.

Cancer Risk Assessment
Cancer Risk Assessment

Author: Ching-Hung Hsu

Publisher: John Wiley & Sons

Published: 2010-12-08

Total Pages: 727

ISBN-13: 1118035127

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With a weight-of-the-evidence approach, cancer risk assessment indentifies hazards, determines dose-response relationships, and assesses exposure to characterize the true risk. This book focuses on the quantitative methods for conducting chemical cancer risk assessments for solvents, metals, mixtures, and nanoparticles. It links these to the basic toxicology and biology of cancer, along with the impacts on regulatory guidelines and standards. By providing insightful perspective, Cancer Risk Assessment helps researchers develop a discriminate eye when it comes to interpreting data accurately and separating relevant information from erroneous.

Histopathology of Preclinical Toxicity Studies
Histopathology of Preclinical Toxicity Studies

Author: Peter Greaves

Publisher: Academic Press

Published: 2011-11-08

Total Pages: 893

ISBN-13: 0444538569

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Chapter 1: Introduction -- Chapter 2: Integumentary System -- -- Skin and subcutaneous tissue -- Chapter 3: Mammary Gland -- Chapter 4: Haemopoietic and Lymphatic Systems -- -- Blood/bone marrow -- -- Lymphoid system -- -- Lymph nodes -- -- Spleen -- -- Thymus -- -- Lymphoreticular neoplasms -- Chapter 5: Musculoskeletal System -- -- Bone -- -- Joints -- -- Skeletal muscle -- Chapter 6: Respiratory Tract -- -- Nose, nasal sinuses, nasopharynx and pharynx -- -- Larynx and trachea -- -- Bronchi and lungs -- Chapter 7: Cardiovascular System -- -- Heart and pericardium -- -- Systemic blood vessels -- -- Pulmonary blood vessels -- Chapter 8: Gastrointestinal tract -- -- Forestomach -- -- Stomach (glandular) -- -- Small intestine -- -- Large intestine -- Chapter 9: Liver and Pancreas -- -- Liver -- -- Bile ducts, biliary system -- -- Pancreas -- Chapter 10: Urinary System -- -- Kidney -- -- Urinary bladder -- Chapter 11: Male Genital Tract -- -- Prostate gland -- -- Epididymis -- -- Testis -- Chapter 12: Female Genital Tract -- -- Vagina -- -- Cervix -- -- Uterus -- -- Ovary -- Chapter 13: Endocrine System -- -- Pituitary gland -- -- Adrenal gland -- -- Thyroid gland -- -- Parathyroid gland -- Chapter 14: Nervous System and Special Sense Organs -- -- Brain -- -- Spinal cord, spinal nerve roots, peripheral nerves -- -- Eye -- -- Ear -- Subject index