Integrative Computational Modeling of Calcium Handling and Cardiac Arrhythmias
Integrative Computational Modeling of Calcium Handling and Cardiac Arrhythmias

Author: Henry Sutanto

Publisher: Henry Sutanto

Published: 2021-01-01

Total Pages: 350

ISBN-13: 946423105X

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Cardiomyocyte calcium handling is a major determinant of excitation-contraction coupling. Alterations in one or more calcium-handling proteins may induce arrhythmias through the formation of ectopic activity, direct and indirect ion-channel regulation, and structural remodeling. Due to the complex and tight interactions between calcium and other molecules within a cardiomyocyte, it remains experimentally challenging to study the exact contributions of calcium-handling abnormalities to arrhythmogenesis. Multiscale computational studies performed in close collaboration with laboratory experiments create new opportunities to unravel the mechanisms of arrhythmogenesis. This thesis describes the roles of integrative computational modeling in unraveling the arrhythmogenic consequences of calcium-handling abnormalities.

IX Latin American Congress on Biomedical Engineering and XXVIII Brazilian Congress on Biomedical Engineering
IX Latin American Congress on Biomedical Engineering and XXVIII Brazilian Congress on Biomedical Engineering

Author: Jefferson Luiz Brum Marques

Publisher: Springer Nature

Published: 2023-12-16

Total Pages: 623

ISBN-13: 3031494016

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This book reports on the latest research and developments in Biomedical Engineering, with a special emphasis on topics of interest and findings achieved in Latin America. This first volume of a 4-volume set covers advances in modeling and simulation of biological and biomedical systems, mechanical characterization, and biological evaluation of biomaterials for medical applications, including tissues regeneration. It also covers some related special topics, such as advanced methodologies for agricultural and food production and public health management. Throughout the book, a special emphasis is given to low-cost technologies and to their development for and applications in clinical settings. Based on the IX Latin American Conference on Biomedical Engineering (CLAIB 2022) and the XXVIII Brazilian Congress on Biomedical Engineering (CBEB 2022), held jointly, and virtually on October 24-28, 2022, from Florianópolis, Brazil, this book provides researchers and professionals in the biomedical engineering field with extensive information on new technologies and current challenges for their clinical applications. .

Computational Science – ICCS 2008
Computational Science – ICCS 2008

Author: Marian Bubak

Publisher: Springer Science & Business Media

Published: 2008-06-11

Total Pages: 769

ISBN-13: 3540693882

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The three-volume set LNCS 5101-5103 constitutes the refereed proceedings of the 8th International Conference on Computational Science, ICCS 2008, held in Krakow, Poland in June 2008. The 167 revised papers of the main conference track presented together with the abstracts of 7 keynote talks and the 100 revised papers from 14 workshops were carefully reviewed and selected for inclusion in the three volumes. The main conference track was divided into approximately 20 parallel sessions addressing topics such as e-science applications and systems, scheduling and load balancing, software services and tools, new hardware and its applications, computer networks, simulation of complex systems, image processing and visualization, optimization techniques, numerical linear algebra, and numerical algorithms. The second volume contains workshop papers related to various computational research areas, e.g.: computer graphics and geometric modeling, simulation of multiphysics multiscale systems, computational chemistry and its applications, computational finance and business intelligence, physical, biological and social networks, geocomputation, and teaching computational science. The third volume is mostly related to computer science topics such as bioinformatics' challenges to computer science, tools for program development and analysis in computational science, software engineering for large-scale computing, collaborative and cooperative environments, applications of workflows in computational science, as well as intelligent agents and evolvable systems.

Cardiac Electrophysiology Methods and Models
Cardiac Electrophysiology Methods and Models

Author: Daniel C. Sigg

Publisher: Springer Science & Business Media

Published: 2010-09-11

Total Pages: 490

ISBN-13: 1441966587

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Cardiovascular disease is the major cause of mortality and morbidity in the Western Hemisphere. While significant progress has been made in treating a major sub-category of cardiac disease, arrhythmias, significant unmet needs remain. In particular, every day, thousands of patients die because of arrhythmias in the US alone, and atrial fibrillation is the most common arrhythmia affecting millions of patients in the US alone at a given time. Therefore, there is a public need to continue to develop new and better therapies for arrhythmias. Accordingly, an ever increasing number of biomedical, pharmaceutical, and medical personnel is interested in studying various aspects of arrhythmias at a basic, translational, and applied level, both in industry (ie Biotech, Pharmaceutical and device), and in academia. Not only has our overall understanding of molecular bases of disease dramatically increased, but so has the number of available and emerging molecular, pharmacological or device treatment based therapies. This practical, state-of-the art handbook will summarize and review key research methods and protocols, their advantages and pitfalls, with a focus on practical implementation, and collaborative cross-functional research. The volume will include visual and easy-to-use graphics, bulleted summaries, boxed summary paragraphs, links to reference websites, equipment manufacturers where appropriate, photographs of typical experimental setups and so forth, to keep this book very focused on practical methods and implementation, and yet, provide enough theory that the principles are clearly understood and can be easily applied.

Modeling and Simulating Cardiac Electrical Activity
Modeling and Simulating Cardiac Electrical Activity

Author: David J. Christini

Publisher:

Published: 2020

Total Pages: 0

ISBN-13: 9780750320641

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This book provides a thorough introduction to the topic of mathematical modeling of electrical activity in the heart, from molecular details of ionic channel dynamics to clinically derived patient-specific models. It discusses how cellular ionic models are formulated, introduces commonly used models and explains why there are so many different models available. The chapters cover modeling of the intracellular calcium handling that underlies cellular contraction as well as modeling molecular-level details of cardiac ion channels, and also focus on specialized topics such as cardiomyocyte energetics and signalling pathways. It is an excellent resource for experienced and specialised researchers in the field, but also biological scientists with a limited background in mathematical modelling and computational methods. Part of Biophysical Society-IOP series.

Methods and applications in integrative physiology
Methods and applications in integrative physiology

Author: Ovidiu Constantin Baltatu

Publisher: Frontiers Media SA

Published: 2023-01-04

Total Pages: 190

ISBN-13: 2832510493

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This Research Topic is part of the Methods and Applications in Physiology series. Other titles in this series are: • Methods and Applications in Aquatic Physiology • Methods and Applications in Clinical and Translational Physiology • Methods and Applications in Computational Physiology and Medicine • Methods and Applications in Environmental, Aviation and Space Physiology • Methods and Applications in Exercise Physiology • Methods and Applications in Fractal Physiology • Methods and Applications in Invertebrate Physiology • Methods and Applications in Metabolic Physiology • Methods and Applications in Physio-logging • Methods and Applications in Striated Muscle Physiology • Methods and Applications in Respiratory Physiology • Methods and Applications in Vascular Physiology • New Methods for Red Blood Cell Research and Diagnosis, Volume II • Combining Computational and Experimental Approaches to Characterize Ion Channels and Transporters

Familial Cardiomyopathies
Familial Cardiomyopathies

Author: Michael Regnier

Publisher: Springer Nature

Published: 2023-12-01

Total Pages: 239

ISBN-13: 1071635271

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This volume covers the latest advances in technologies that look at familial cardiomyopathies in greater detail, and provides new computational and experimental models that model, study, and detect disease at earlier stages. Together, this allows interdisciplinary research experiments to provide new insights for the development of novel interventions that slow, stop, or even reverse the disease process. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and practical, Familial Cardiomyopathies: Methods and Protocols aims to inspire further development of techniques used to study myocardial disease and the development of new, sarcomere-targeted therapeutic approaches for the maintenance of heart health and the treatment of heart failure.

Cardiac Mapping
Cardiac Mapping

Author: Mohammad Shenasa

Publisher: John Wiley & Sons

Published: 2019-04-04

Total Pages: 1307

ISBN-13: 1119152623

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The expanded guide to cardiac mapping The effective diagnosis and treatment of heart disease may vitally depend upon accurate and detailed cardiac mapping. However, in an era of rapid technological advancement, medical professionals can encounter difficulties maintaining an up-to-date knowledge of current methods. This fifth edition of the much-admired Cardiac Mapping is, therefore, essential, offering a level of cutting-edge insight that is unmatched in its scope and depth. Featuring contributions from a global team of electrophysiologists, the book builds upon previous editions comprehensive explanations of the mapping, imaging, and ablation of the heart. Nearly 100 chapters provide fascinating accounts of topics ranging from the mapping of supraventricular and ventriculararrhythmias, to compelling extrapolations of how the field might develop in the years to come. In this text, readers will find: Full coverage of all aspects of cardiac mapping, and imaging Explorations of mapping in experimental models of arrhythmias Examples of new catheter-based techniques Access to a companion website featuring additional content and illustrative video clips Cardiac Mapping is an indispensable resource for scientists, clinical electrophysiologists, cardiologists, and all physicians who care for patients with cardiac arrhythmias.

The Role of Calcium Handling in Heart Failure and Heart Failure Associated Arrhythmias
The Role of Calcium Handling in Heart Failure and Heart Failure Associated Arrhythmias

Author: Elisabetta Cerbai

Publisher: Frontiers Media SA

Published: 2019-05-15

Total Pages: 191

ISBN-13: 2889458253

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Under normal, healthy conditions, the contraction of cardiac myocytes, leading to the pump function of this organ, is driven by calcium-dependent mechanisms. Entry of calcium into the myocyte during the cardiac action potential causes activation of the ryanodine receptors and release of calcium from the sarcoplasmic reticulum. This process termed calcium-induced calcium release is essential for excitation-contraction coupling and enables each action potential to be transduced into a mechanical event. Indeed, in healthy myocytes, the calcium concentration in the cytosol of is elevated approximately 10-fold from a resting level of ∼100 nM to ∼1 μM. This process is finely orchestrated by a number of key proteins, which can be specifically regulated by various pathways depending on the oxygen demand. Furthermore, the specific structure of the myocyte allows certain calcium-dependent processes to be compartmentalised, increasing the efficiency and safety of this regulation. Heart failure is a common, costly, and life-threatening condition. In 2015, for example, it affected around 40 million people globally. In patients with heart failure, the risk of sudden cardiac death and arrhythmias increases substantially. Cellular remodelling and alterations in calcium handling, which appear to contribute to the arrhythmogenic burden in heart failure, have been extensively reported. However, a number of unanswered questions remain, and each new study - while continuing to shed light on this subject - raises additional novel questions. This current compendium of articles covers a number of aspects and comprehensively reviews current knowledge and perspectives regarding the link between calcium handling, arrhythmias and heart failure providing at the same time insights that may lead to novel therapeutic options for the future.