The Cerebral Circulation

The Cerebral Circulation

Author: Marilyn J. Cipolla

Publisher: Biota Publishing

Published: 2016-07-28

Total Pages: 82

ISBN-13: 1615047239

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This e-book will review special features of the cerebral circulation and how they contribute to the physiology of the brain. It describes structural and functional properties of the cerebral circulation that are unique to the brain, an organ with high metabolic demands and the need for tight water and ion homeostasis. Autoregulation is pronounced in the brain, with myogenic, metabolic and neurogenic mechanisms contributing to maintain relatively constant blood flow during both increases and decreases in pressure. In addition, unlike peripheral organs where the majority of vascular resistance resides in small arteries and arterioles, large extracranial and intracranial arteries contribute significantly to vascular resistance in the brain. The prominent role of large arteries in cerebrovascular resistance helps maintain blood flow and protect downstream vessels during changes in perfusion pressure. The cerebral endothelium is also unique in that its barrier properties are in some way more like epithelium than endothelium in the periphery. The cerebral endothelium, known as the blood-brain barrier, has specialized tight junctions that do not allow ions to pass freely and has very low hydraulic conductivity and transcellular transport. This special configuration modifies Starling's forces in the brain microcirculation such that ions retained in the vascular lumen oppose water movement due to hydrostatic pressure. Tight water regulation is necessary in the brain because it has limited capacity for expansion within the skull. Increased intracranial pressure due to vasogenic edema can cause severe neurologic complications and death.


Mechanisms of Vascular Disease

Mechanisms of Vascular Disease

Author: Robert Fitridge

Publisher: University of Adelaide Press

Published: 2011

Total Pages: 589

ISBN-13: 1922064009

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New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.


Regulation of Tissue Oxygenation, Second Edition

Regulation of Tissue Oxygenation, Second Edition

Author: Roland N. Pittman

Publisher: Biota Publishing

Published: 2016-08-18

Total Pages: 117

ISBN-13: 1615047212

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This presentation describes various aspects of the regulation of tissue oxygenation, including the roles of the circulatory system, respiratory system, and blood, the carrier of oxygen within these components of the cardiorespiratory system. The respiratory system takes oxygen from the atmosphere and transports it by diffusion from the air in the alveoli to the blood flowing through the pulmonary capillaries. The cardiovascular system then moves the oxygenated blood from the heart to the microcirculation of the various organs by convection, where oxygen is released from hemoglobin in the red blood cells and moves to the parenchymal cells of each tissue by diffusion. Oxygen that has diffused into cells is then utilized in the mitochondria to produce adenosine triphosphate (ATP), the energy currency of all cells. The mitochondria are able to produce ATP until the oxygen tension or PO2 on the cell surface falls to a critical level of about 4–5 mm Hg. Thus, in order to meet the energetic needs of cells, it is important to maintain a continuous supply of oxygen to the mitochondria at or above the critical PO2 . In order to accomplish this desired outcome, the cardiorespiratory system, including the blood, must be capable of regulation to ensure survival of all tissues under a wide range of circumstances. The purpose of this presentation is to provide basic information about the operation and regulation of the cardiovascular and respiratory systems, as well as the properties of the blood and parenchymal cells, so that a fundamental understanding of the regulation of tissue oxygenation is achieved.


The Venous Drainage of the Human Myocardium

The Venous Drainage of the Human Myocardium

Author: Michael Lüdinghausen

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 112

ISBN-13: 364255623X

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The objective of this study is to present comprehensive morphological data, almost all of it is new, concerning the venous drainage of the myocardium via the coronary sinus and its related veins. This information is of great significance, not least for the sucessful coronary sinus catheterization and reperfusion of most, or single, cardiac veins.The author presents the three principal cardiac venous systems, the greater (major) cardiac venous, the smaller (minor) cardiac venous system, and the compound venous system. The work concludes with an evaluation of the many anatomical peculiarities and and hindrances with regard to the catheterization of the coronary sinus and the reperfusion of (selected) cardiac veins.


Open Veins of Latin America

Open Veins of Latin America

Author: Eduardo Galeano

Publisher: NYU Press

Published: 1997

Total Pages: 335

ISBN-13: 0853459908

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[In this book, the author's] analysis of the effects and causes of capitalist underdevelopment in Latin America present [an] account of ... Latin American history. [The author] shows how foreign companies reaped huge profits through their operations in Latin America. He explains the politics of the Latin American bourgeoisies and their subservience to foreign powers, and how they interacted to create increasingly unequal capitalist societies in Latin America.-Back cover.


Regulation of Coronary Blood Flow

Regulation of Coronary Blood Flow

Author: Michitoshi Inoue

Publisher: Springer Science & Business Media

Published: 2013-11-09

Total Pages: 330

ISBN-13: 4431683674

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Research centering on blood flow in the heart continues to hold an important position, especially since a better understanding of the subject may help reduce the incidence of coronary arterial disease and heart attacks. This book summarizes recent advances in the field; it is the product of fruitful cooperation among international scientists who met in Japan in May, 1990 to discuss the regulation of coronary blood flow.


War of the Bloods in My Veins

War of the Bloods in My Veins

Author: DaShaun "Jiwe" Morris

Publisher: Simon and Schuster

Published: 2009-01-27

Total Pages: 245

ISBN-13: 1416565337

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By turns harrowing, moving, and ultimately redemptive, this is a war story -- a war that rages out of control on the streets of the United States, claiming the lives of our loved ones and neighbors. In this memoir, complete with child soldiers, unspeakable violence, and eventual salvation, we witness the journey of an East Coast member of the notorious Bloods gang coming to terms with the lost boy he was and the transformation into the man he wants to become. Unlike the child warriors of Mozambique and Sierra Leone, gang members and the wars they wage are the United States' homegrown nightmare. Lacking protection, support, or any alternatives, Dashaun Morris is forced into battle for the first time at age eleven, in the streets of Phoenix, when a friend's older brothers put him in a car filled with 40s and weed smoke, put a gun in his hands, then make him point it at the men on the corner and squeeze the trigger. The targets are Crips, of course, and, as Morris writes, "In the darkness of the streets, my childhood is murdered.... I am reborn -- a gangster." In this haunting, violent memoir, Morris takes us through an American childhood turned grotesquely inside out. In the fourth grade, he loses his first friend in a drive-by shooting. By high school he is the man, a champion on the football field by day and a reputable banger on his 'hood turf by night. Living the life of a gang banger, Morris does it all -- drug dealing, jacking, and continuing the aimless war with rival gang members -- almost opening fire one night on a close friend, a cheerleader, as she hangs out with young men he mistakes for Crips. He eventually makes it to college on a football scholarship, but on the verge of being drafted by the NFL, Morris can't escape his gang-banging mentality and gets caught up in crimes that snatch away all future hopes. Sitting in a prison cell, he anticipates the birth of his first child while counting the friends he's buried. War of the Bloods in My Veins is part of Morris's redemption, a cry to his brothers that gang life is mental illness. It is a rare and brutally honest look into the relentless storm of abandonment, violence, crime, death, and the endless rush toward the complete and utter self-annihilation that plagues the lives of the young "soldiers" who die every day in our streets.


Catheter Ablation of Atrial Fibrillation

Catheter Ablation of Atrial Fibrillation

Author: Etienne Aliot

Publisher: John Wiley & Sons

Published: 2011-08-31

Total Pages: 333

ISBN-13: 1444356143

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Catheter Ablation of Atrial Fibrillation Edited by Etienne Aliot, MD, FESC, FACC, FHRS Chief of Cardiology, Hôpital Central, University of Nancy, France Michel Haïssaguerre, MD Chief of Electrophysiology, Hôpital Cardiologique du Haut-Lévêque, France Warren M. Jackman, MD Chief of Electrophysiology, University of Oklahoma Health Science Center, USA In this text, internationally recognized authors explore and explain the advances in basic and clinical electrophysiology that have had the greatest impact on catheter ablation of atrial fibrillation (AF). Designed to assist in patient care, stimulate research projects, and continue the remarkable advances in catheter ablation of AF, the book covers: the fundamental concepts of AF, origin of signals, computer simulation, and updated reviews of ablation tools the present practical approaches to the ablation of specific targets in the fibrillating atria, including pulmonary veins, atrial neural network, fragmented electrograms, and linear lesions, as well as the strategies in paroxysmal or chronic AF or facing left atrial tachycardias the special challenge of heart failure patients, the impact of ablation on mortality, atrial mechanical function, and lessons from surgical AF ablation Richly illustrated by numerous high-quality images, Catheter Ablation of Atrial Fibrillation will help every member of the patient care team.