Innate Tolerance in the CNS
Author: Springer
Publisher:
Published: 2012-09-22
Total Pages: 712
ISBN-13: 9781441996961
DOWNLOAD EBOOKRead and Download eBook Full
Author: Springer
Publisher:
Published: 2012-09-22
Total Pages: 712
ISBN-13: 9781441996961
DOWNLOAD EBOOKAuthor: Jeffrey M. Gidday
Publisher: Springer Science & Business Media
Published: 2012-09-21
Total Pages: 685
ISBN-13: 144199694X
DOWNLOAD EBOOKCerebral preconditioning is a phenomenon wherein a mild insult or stress induces cellular and tissue adaptation or tolerance to a later, severe injury, therefore reflecting the efficacy of endogenous mechanisms of cerebrovascular protection. Initially identified for rapid cardiac protection, preconditioning has expanded to all aspects of CNS protection from ischemia, trauma and potentially neurodegeneration. Many different stimuli or stressors have been identified as preconditioning agents, suggesting a downstream convergence of mechanisms and underscoring the potential for translational application of preconditioning in the clinic. Moreover, the fundamental mechanisms responsible for preconditioning-induced tolerance will help in the design novel pharmacological approaches for neuroprotection. While stroke and many other brain injuries are not predictable, in some populations (e.g., metabolic syndrome, patients undergoing carotid endarterectomy, aneurysm clipping, or with recent TIAs) the risk for stroke is identifiable and significant, and preconditioning may represent a useful strategy for neuroprotection. For unpredictable injuries, post-conditioning the brain – or inducing endogenous protective mechanisms after the initial injury – can also abrogate the extent of injury. Finally, remote pre- and post-conditioning methods have been developed in animals, and are now being tested in clinical trials, wherein a brief, noninjurious stress to a noncerebral tissue (i.e., skeletal muscle) can provide protection to the CNS and thereby allows clinicians the opportunity to circumvent concerns regarding the direct preconditioning of neurological tissues.
Author: Jeffrey M. Gidday
Publisher: Springer Science & Business Media
Published: 2012-09-21
Total Pages: 685
ISBN-13: 1441996958
DOWNLOAD EBOOKCerebral preconditioning is a phenomenon wherein a mild insult or stress induces cellular and tissue adaptation or tolerance to a later, severe injury, therefore reflecting the efficacy of endogenous mechanisms of cerebrovascular protection. Initially identified for rapid cardiac protection, preconditioning has expanded to all aspects of CNS protection from ischemia, trauma and potentially neurodegeneration. Many different stimuli or stressors have been identified as preconditioning agents, suggesting a downstream convergence of mechanisms and underscoring the potential for translational application of preconditioning in the clinic. Moreover, the fundamental mechanisms responsible for preconditioning-induced tolerance will help in the design novel pharmacological approaches for neuroprotection. While stroke and many other brain injuries are not predictable, in some populations (e.g., metabolic syndrome, patients undergoing carotid endarterectomy, aneurysm clipping, or with recent TIAs) the risk for stroke is identifiable and significant, and preconditioning may represent a useful strategy for neuroprotection. For unpredictable injuries, post-conditioning the brain – or inducing endogenous protective mechanisms after the initial injury – can also abrogate the extent of injury. Finally, remote pre- and post-conditioning methods have been developed in animals, and are now being tested in clinical trials, wherein a brief, noninjurious stress to a noncerebral tissue (i.e., skeletal muscle) can provide protection to the CNS and thereby allows clinicians the opportunity to circumvent concerns regarding the direct preconditioning of neurological tissues.
Author: Antonio Noronha
Publisher: Elsevier
Published: 2014-05-02
Total Pages: 573
ISBN-13: 0124071554
DOWNLOAD EBOOKRecent scientific advances have provided substantial information on the brain circuits and pathways relevant to various aspects of dependence. Neurobiology of Alcohol Dependence highlights the most recent data at the molecular, cellular, neurocircuitry, and behavioral levels, fostering an understanding how neuroplasticity and neuroadaptation occur, and how different neural pathways and neurocircuits contribute to dependence. Highlights recent advances in understanding alcohol addiction from molecular, cellular, neurocircuitry, and behavioral levels Integrates several emerging areas of research and discusses the application of novel research techniques to the understanding of alcohol dependence Chapters authored by leaders in the field around the globe — the broadest, most expert coverage available
Author: Institute of Medicine
Publisher: National Academies Press
Published: 2002-01-07
Total Pages: 172
ISBN-13: 0309082587
DOWNLOAD EBOOKThis report from the Committee on Military Nutrition Research reviews the history of caffeine usage, the metabolism of caffeine, and its physiological effects. The effects of caffeine on physical performance, cognitive function and alertness, and alleviation of sleep deprivation impairments are discussed in light of recent scientific literature. The impact of caffeine consumption on various aspects of health, including cardiovascular disease, reproduction, bone mineral density, and fluid homeostasis are reviewed. The behavioral effects of caffeine are also discussed, including the effect of caffeine on reaction to stress, withdrawal effects, and detrimental effects of high intakes. The amounts of caffeine found to enhance vigilance and reaction time consistently are reviewed and recommendations are made with respect to amounts of caffeine appropriate for maintaining alertness of military personnel during field operations. Recommendations are also provided on the need for appropriate labeling of caffeine-containing supplements, and education of military personnel on the use of these supplements. A brief review of some alternatives to caffeine is also provided.
Author: Kenneth Murphy
Publisher: Garland Science
Published: 2010-06-22
Total Pages:
ISBN-13: 9780815344575
DOWNLOAD EBOOKThe Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
Author: Bertha Madras
Publisher: Elsevier
Published: 2013-11-15
Total Pages: 625
ISBN-13: 0124186858
DOWNLOAD EBOOKDrug use and abuse continues to thrive in contemporary society worldwide and the instance and damage caused by addiction increases along with availability. The Effects of Drug Abuse on the Human Nervous System presents objective, state-of-the-art information on the impact of drug abuse on the human nervous system, with each chapter offering a specific focus on nicotine, alcohol, marijuana, cocaine, methamphetamine, MDMA, sedative-hypnotics, and designer drugs. Other chapters provide a context for drug use, with overviews of use and consequences, epidemiology and risk factors, genetics of use and treatment success, and strategies to screen populations and provide appropriate interventions. The book offers meaningful, relevant and timely information for scientists, health-care professionals and treatment providers. A comprehensive reference on the effects of drug addiction on the human nervous system Focuses on core drug addiction issues from nicotine, cocaine, methamphetamine, alcohol, and other commonly abused drugs Includes foundational science chapters on the biology of addiction Details challenges in diagnosis and treatment options
Author: Bruce Alberts
Publisher:
Published: 2002
Total Pages: 0
ISBN-13: 9780815332183
DOWNLOAD EBOOKAuthor: Philip Conaghan
Publisher: Oxford University Press
Published: 2013-10
Total Pages: 1553
ISBN-13: 0199642486
DOWNLOAD EBOOKA strong clinical emphasis is present throughout this volume from the first section of commonly presenting problems through to the section addressing problems shared with a range of other clinical sub-specialties.
Author: Samuel Obembe
Publisher: Elsevier
Published: 2012-10-11
Total Pages: 121
ISBN-13: 0124016618
DOWNLOAD EBOOKThis insightful book is a synoptic presentation of Causes and Treatment of Alcoholism and Drug Addiction. It gives an insight into Alcoholism and Drug Addiction genetic and/or acquired etiologies through researched studies that draw the conclusion that Addiction is a disease/ medical condition. It features the treatment from detox followed by psychotherapy with evidence based practices and supported by Aftercare programs to maintain sobriety and recovery. An insight into Alcoholism and Drug Addiction Psychotherapy with evidence based practices Aftercare programs Classification and effects of psychoactive drugs Drug screening procedures Motivational Interviewing Causes and Treatment of Alcoholism and Drug Addiction Life and clinical experiences Culture and Drug Addiction Levels of Care in Structured Programs