Molecular Biology of the Cell
Author:
Publisher:
Published: 2002
Total Pages: 0
ISBN-13: 9780815332183
DOWNLOAD EBOOKPosts
Janeway's Immunobiology
Author: Kenneth Murphy
Publisher: Garland Science
Published: 2010-06-22
Total Pages:
ISBN-13: 9780815344575
DOWNLOAD EBOOKThe Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
The Innate Immune System
Author: Tomi Monie
Publisher: Academic Press
Published: 2017-02-20
Total Pages: 0
ISBN-13: 9780128044643
DOWNLOAD EBOOKThe Innate Immune System: A Compositional and Functional Perspective focuses on the components and functionality of the innate immune system, detailing how they work in their own right, and then progressing to cover their relevance to disease and how they interface with the adaptive response. Despite the growing appreciation of the importance of the innate immune system, many classical immunology books still focus predominantly on the adaptive immune response. Not only is this unbalanced, but it fails to reflect the growing synergy between the activation and function of the innate response and the final nature of adaptive response. This book fills the gap in knowledge that is needed to fully understand and appreciate the topic.
Innate Immunity and Inflammation
Author: Ruslan Medzhitov
Publisher: Cold Spring Harbor Perspective
Published: 2015
Total Pages: 0
ISBN-13: 9781621820291
DOWNLOAD EBOOK"A subject collection from Cold Spring Harbor perspectives in biology."
Innate Immunity: Resistance and Disease-Promoting Principles
Author: G. Hartmann
Publisher: Karger Medical and Scientific Publishers
Published: 2013-06-05
Total Pages: 140
ISBN-13: 3318023485
DOWNLOAD EBOOKOur understanding of the complex innate immune response is increasing rapidly. Its role in the protection against viral or bacterial pathogens is essential for the survival of an organism. However, it is equally important to avoid unregulated inflammation because innate immune responses can cause or promote chronic autoinflammatory diseases such as gout, atherosclerosis, type 2 diabetes or certain aspects of the metabolic syndrome. In this book leading international experts in the field of innate immunity share their findings, define the ‚state of the art‘ in this field and evaluate how insight into the molecular basis of these diseases could help in the design of new therapies. A tremendous amount of work on the innate immune response has been done over the last fifteen years, culminating in the 2011 Nobel Prize in Physiology/Medicine awarded for the discoveries of Toll genes in immunity in flies, membrane-bound Toll-like receptors in mammals, and dendritic cells as initiators of adaptive immunity.
The Innate Immune Response to Noninfectious Stressors
Author: Massimo Amadori
Publisher: Academic Press
Published: 2016-02-23
Total Pages: 278
ISBN-13: 0128019743
DOWNLOAD EBOOKThe Innate Immune Response to Non-infectious Stressors: Human and Animal Models highlights fundamental mechanisms of stress response and important findings on how the immune system is affected, and in turn affects such a response. In addition, this book covers the crucial link between stress response and energy metabolism, prompts a re-appraisal of some crucial issues, and helps to define research priorities in this fascinating, somehow elusive field of investigation. - Provides insights into the fundamental homeostatic processes vis-à-vis stressors to help in investigation - Illustrates the depicted tenets and how to offset them against established models of response to physical and psychotic stressors in both animals and humans - Covers the crucial issue of the immune response to endocrine disruptors - Includes immunological parameters as reporter system of environmental adaptation - Provides many illustrative examples to foster reader understanding
Mouse Models of Innate Immunity
Author: Irving C. Allen
Publisher: Humana
Published: 2016-08-27
Total Pages: 0
ISBN-13: 9781493960361
DOWNLOAD EBOOKThe innate immune system represents a critical arm of the immune response by providing immediate and robust host defense; however, human studies of its function are often limited by ethical, logistical, and technical obstacles. In Mouse Models of Innate Immunity: Methods and Protocols, experts in the field explore the design and execution of experiments used to thoroughly evaluate critical elements associated with the host innate immune response. The volume opens with methods that are essential for collecting and assessing various primary cells that are highly relevant to innate immunity, and it continues with in vivo protocols commonly used to evaluate the innate immune response in the mouse, including mouse models of respiratory infection, gastrointestinal inflammation, fungal and parasitic diseases, sepsis, and HIV-1 infection. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and easy to use, Mouse Models of Innate Immunity: Methods and Protocols will serve the research community by providing expert advice and protocols that allow both experienced and novice investigators to successfully plan, implement, and assess disease processes associated with the innate immune response.
Antibody Fc
Author: Margaret Ackerman
Publisher: Academic Press
Published: 2013-08-06
Total Pages: 376
ISBN-13: 0123948185
DOWNLOAD EBOOKAntibody Fc is the first single text to synthesize the literature on the mechanisms underlying the dramatic variability of antibodies to influence the immune response. The book demonstrates the importance of the Fc domain, including protective mechanisms, effector cell types, genetic data, and variability in Fc domain function. This volume is a critical single-source reference for researchers in vaccine discovery, immunologists, microbiologists, oncologists and protein engineers as well as graduate students in immunology and vaccinology. Antibodies represent the correlate of protection for numerous vaccines and are the most rapidly growing class of drugs, with applications ranging from cancer and infectious disease to autoimmunity. Researchers have long understood the variable domain of antibodies, which are responsible for antigen recognition, and can provide protection by blocking the function of their target antigen. However, recent developments in our understanding of the protection mediated by antibodies have highlighted the critical nature of the antibody constant, or Fc domain, in the biological activity of antibodies. The Fc domain allows antibodies to link the adaptive and innate immune systems, providing specificity to a wide range of innate effector cells. In addition, they provide a feedback loop to regulate the character of the immune response via interactions with B cells and antigen-presenting cells. - Clarifies the different mechanisms of IgG activity at the level of the different model systems used, including human genetic, mouse, and in vitro - Covers the role of antibodies in cancer, infectious disease, and autoimmunity and in the setting of monoclonal antibody therapy as well as naturally raised antibodies - Color illustrations enhance explanations of the immune system
Toll-Like Receptors (TLRs) and Innate Immunity
Author: Stefan Bauer
Publisher: Springer Science & Business Media
Published: 2007-12-11
Total Pages: 243
ISBN-13: 3540721673
DOWNLOAD EBOOKOverall recent research on TLRs has led to tremendous increase in our understanding of early steps in pathogen recognition and will presumably lead to potent TLR targeting therapeutics in the future. This book reviews and highlights our recent understanding on the function and ligands of TLRs as well as their role in autoimmunity, dendritic cell activation and target structures for therapeutic intervention.
Fundamentals of Inflammation
Author: Charles N. Serhan
Publisher: Cambridge University Press
Published: 2010-04-26
Total Pages: 489
ISBN-13: 1139936670
DOWNLOAD EBOOKThe acute inflammatory response is the body's first system of alarm signals that are directed toward containment and elimination of microbial invaders. Uncontrolled inflammation has emerged as a pathophysiologic basis for many widely occurring diseases in the general population that were not initially known to be linked to the inflammatory response, including cardiovascular disease, asthma, arthritis, and cancer. To better manage treatment, diagnosis, and prevention of these wide-ranging diseases, multidisciplinary research efforts are underway in both academic and industry settings. This book provides an introduction to the cell types, chemical mediators, and general mechanisms of the host's first response to invasion. World-class experts from institutions around the world have written chapters for this introductory text. The text is presented as an introductory springboard for graduate students, medical scientists, and researchers from other disciplines wishing to gain an appreciation and working knowledge of current cellular and molecular mechanisms fundamental to inflammation.
