Discovery and Development of Antidiabetic Agents from Natural Products

Discovery and Development of Antidiabetic Agents from Natural Products

Author: Goutam Brahmachari

Publisher: Elsevier

Published: 2016-10-11

Total Pages: 334

ISBN-13: 0128096926

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Discovery and Development of Antidiabetic Agents from Natural Products brings together global research on the medicinal chemistry of active agents from natural sources for the prevention and treatment of diabetes and associated disorders. From the identification of promising leads, to the extraction and synthesis of bioactive molecules, this book explores a range of important topics to support chemists in the discovery and development of safer, more economical therapeutics that are desperately needed in response to this emerging global epidemic. Beginning with an overview of bioactive chemical compounds from plants with anti-diabetic properties, the book goes on to outline the identification and extraction of anti-diabetic agents and antioxidants from natural sources. It then explores anti-diabetic plants from specific regions before looking more closely at the background, isolation, and synthesis of key therapeutic compounds and their derivatives, including Mangiferin, Resveratrol, natural saponins, and alpha-glucosidase enzyme inhibitors. The book concludes with a consideration of current and potential future applications. Combining the expertise of specialists from around the world, this volume aims to support and encourage medicinal chemists investigating natural sources as starting points for the development of standardized, safe, and effective antidiabetic therapeutics. - Contains chapters written by active researchers and leading global experts who are deeply engaged in the research field of natural product chemistry for drug discovery - Provides comprehensive coverage of cutting-edge research advances in the design of medicinal natural products with potential as preventives and therapeutics for diabetes and related metabolic issues - Presents a practical review of the identification, isolation, and extraction techniques that help support medicinal chemists in the lab


Current Advances for Development of Functional Foods Modulating Inflammation and Oxidative Stress

Current Advances for Development of Functional Foods Modulating Inflammation and Oxidative Stress

Author: Blanca Hernandez-Ledesma

Publisher: Academic Press

Published: 2021-12-03

Total Pages: 676

ISBN-13: 012822584X

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Current Advances for Development of Functional Foods Modulating Inflammation and Oxidative Stress presents the nutritional and technological aspects related to the development of functional foods with anti-inflammatory and antioxidant effects. Specifically, analytical approaches for the characterization of anti-inflammatory and antioxidant properties of healthy foods and functional constituents, as well as technological strategies for the extraction of compounds and fractions from raw materials to produce anti-inflammatory and antioxidant ingredients are addressed. In addition, the molecular mechanisms by which foods and their components can modulate inflammation and their oxidative stress effects on disease prevention are explored. Finally, clinical research addressing nutritional needs in pathological subjects with inflammatory diseases are considered. - Covers methods of analysis and extraction of anti-inflammatory and antioxidant compounds - Offers an overview of the main anti-inflammatory and antioxidant compounds in foods - Provides a guide on the mechanisms of action and health benefits of anti-inflammatory and antioxidant dietary bioactives


Anti-inflammatory Nutraceuticals and Chronic Diseases

Anti-inflammatory Nutraceuticals and Chronic Diseases

Author: Subash Chandra Gupta

Publisher: Springer

Published: 2016-09-26

Total Pages: 479

ISBN-13: 3319413341

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This comprehensive volume focuses on anti-inflammatory nutraceuticals and their role in various chronic diseases. Food and Drug Administration (FDA) approved drugs such as steroids, non-steroidal anti-inflammatory drugs (NSAIDS), statins and metformin have been shown to modulate inflammatory pathways, but their long-term intake has been associated with numerous side effects. This means that there is enormous potential for dietary agents that can modulate inflammatory pathways in humans. Leading experts describe the latest research on the role of anti-inflammatory nutraceuticals in preventing and treating chronic diseases.


Antioxidants in Sport Nutrition

Antioxidants in Sport Nutrition

Author: Manfred Lamprecht

Publisher: CRC Press

Published: 2014-09-17

Total Pages: 304

ISBN-13: 1466567570

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The use of antioxidants in sports is controversial due to existing evidence that they both support and hinder athletic performance. Antioxidants in Sport Nutrition covers antioxidant use in the athlete ́s basic nutrition and discusses the controversies surrounding the usefulness of antioxidant supplementation. The book also stresses how antioxidants may affect immunity, health, and exercise performance. The book contains scientifically based chapters explaining the basic mechanisms of exercise-induced oxidative damage. Also covered are methodological approaches to assess the effectiveness of antioxidant treatment. Biomarkers are discussed as a method to estimate the bioefficacy of dietary/supplemental antioxidants in sports. This book is useful for sport nutrition scientists, physicians, exercise physiologists, product developers, sport practitioners, coaches, top athletes, and recreational athletes. In it, they will find objective information and practical guidance.


Anti-Inflammatory Foods for Health

Anti-Inflammatory Foods for Health

Author: Barbara Rowe

Publisher: Fair Winds Press

Published: 2008-01-01

Total Pages: 193

ISBN-13: 1616734280

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Great food for inflammation sufferers. Cut your finger accidentally and the area will swell, redden, and heat up. This type of acute inflammatory response is the body's reaction to trauma, and it's an essential part of the healing process. But inflammation can be harmful when it hangs around too long and refuses to leave. When the inflammation switch refuses to turn off, the body operates as if it is always under attack (the older we get, the more likely this is to happen). White blood cells flood the system for weeks, months, and even years. Researchers are now linking low-grade, persistent inflammation to premature aging, heart disease, M.S., diabetes, Alzheimer's, psoriasis, arthritis, and cancer. While anti-inflammatory drugs do exist, they can injure the stomach or suppress the immune system. Fortunately, the situation can be remedied by a change in diet, specifically by altering the kinds of fats you eat. Omega-3 fatty acids tend to decrease inflammation while omega-6 fats and trans-fats increase inflammation. While many foods in the standard American diet (unrefined white flour, sugar, red meat, diary, fast food, and food additives) exacerbate inflammation, a healthy diet made up of fish, nuts, seeds, oils, lean grass-fed meats, and fruits and vegetables can help lessen or prevent inflammation. Likewise, certain spices such as turmeric, cloves, and ginger have proven anti-inflammatory activity. Anti-Inflammatory Foods for Health will help those with inflammation incorporate anti-inflammatory foods into their everyday diet. Sample recipes may include French-Canadian Pea Soup, Sumac Salmon, Maple-Ginger Butternut Squash, Lime-Ginger Glazed Chicken with Fennel Relish, Green Salad with Grapes and Sunflower Seeds, Cod with Saffron Sauce, and more.


Natural Remedies for Inflammation

Natural Remedies for Inflammation

Author: Christopher Vasey

Publisher: Simon and Schuster

Published: 2014-11-15

Total Pages: 144

ISBN-13: 1620553244

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An illustrated guide to natural relief from chronic inflammation • Explores the use of 18 anti-inflammatory herbs, such as bay laurel, basil, turmeric, and devil’s claw, as well as 15 other natural substances, such as propolis and fish oil • Examines which natural remedy is best for many common inflammation-related ailments, such as asthma, bronchitis, tendonitis, arthritis, and eczema • Reveals the important role of omega-3s in defending the body against inflammation From aspirin and ibuprofen to antihistamines and cortisone, anti-inflammatory drugs are now the top-selling pharmaceuticals in the world. But daily use of these powerful drugs comes with a price: side effects, many of which can lead to other chronic conditions and the further use of medications. In this practical guide to natural remedies for inflammation, naturopath Christopher Vasey explores 18 anti-inflammatory herbs, such as bay laurel, basil, turmeric, and devil’s claw, as well as 15 other natural substances, such as propolis and fish oil. He explains which conditions each addresses most effectively, proper dosage, and the best methods of ingestion. Vasey explains how, like fever, inflammation is a defensive reaction of the body and also carries out a cleansing process, which natural remedies support but pharmaceuticals can destabilize by contributing more toxins to the internal terrain. He examines 50 of the most common inflammation-related ailments--such as allergies, asthma, conjunctivitis, bronchitis, sinusitis, cystitis, tendinitis, arthritis, eczema, and sciatica--and explains which medicinal plant or food supplement is best suited to safely alleviate unpleasant symptoms while helping the body complete the healing the inflammation was initiated to perform. Revealing the important role of omega-3s in defending the body against inflammation and reducing the damage caused by chronic inflammation, Vasey explores what foods are rich in these key molecules, how much must be eaten to defend the body, and what omega-3 supplements are most suited to your body’s needs. The author also examines how to deacidify the body, as acids have an inflammatory effect, as well as how to use hydrotherapy to calm inflammation.


Drug Discovery from Mother Nature

Drug Discovery from Mother Nature

Author: Subash Chandra Gupta

Publisher: Springer

Published: 2016-10-22

Total Pages: 411

ISBN-13: 3319413422

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Second comprehensive volume focuses on anti-inflammatory nutraceuticals and their role in prevention and therapy of various chronic diseases. Food and drug administration (FDA) approved drugs such as steroids, non-steroidal anti-inflammatory drugs (NSAIDS), statins and metformin have been shown to modulate inflammatory pathways, but their long-term intake has been associated with numerous side effects. Thus dietary agents which can modulate inflammatory pathways in humans, are likely to exhibit enormous potential. Leading experts describe the latest results of anti-inflammatory nutraceuticals and their role in prevention and therapy of various chronic diseases.


Meals That Heal Inflammation

Meals That Heal Inflammation

Author: Julie Daniluk, RHN

Publisher: Hay House, Inc

Published: 2012-06-15

Total Pages: 418

ISBN-13: 1401940358

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Did you know that virtually every health condition from asthma to irritable bowel syndrome is linked to inflammation? When inflammation gets out of control, the result is pain and discomfort—and it’s a phenomenon that’s on the rise. If you’re one of the millions of people who have been affected by allergies, diabetes, skin disorders, heart disease, arthritis, or any other condition ending in "-itis," then you know firsthand what havoc inflammation can cause. In Meals That Heal Inflammation, television personality and registered holistic nutritionist Julie Daniluk shows you how to conquer these health conditions with foods that will make you feel fantastic. This comprehensive book is packed with meals that can assist the body’s healing process—all while treating your taste buds to new and delicious flavors. The recipes, from healing teas to balanced meals and tempting desserts, are simple to make. Whether it’s the savory cranberry quinoa salad or the sumptuous key lime pie, every recipe in this book contains foods that naturally heal inflammation. Extensively researched and full of reference charts, diagnostic quizzes, food comparison lists, and the latest information about the healing properties of everyday foods, Meals That Heal Inflammation is an essential addition to every kitchen.


The Benefits of Natural Products for Neurodegenerative Diseases

The Benefits of Natural Products for Neurodegenerative Diseases

Author: M. Mohamed Essa

Publisher: Springer

Published: 2016-09-20

Total Pages: 497

ISBN-13: 3319283839

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Focuses on the effects of natural products and their active components on brain function and neurodegenerative disease prevention. Phytochemicals such as alkaloids, terpenes, flavanoids, isoflavones, saponins etc are known to possess protective activity against many neurological diseases. The molecular mechanisms behind the curative effects rely mainly on the action of phytonutrients on distinct signaling pathways associated with protein folding and neuro-inflammation. The diverse array of bioactive nutrients present in these natural products plays a pivotal role in prevention and cure of various neurodegenerative diseases, disorders, or insults, such as Alzheimer's Disease, Parkinson's Disease, Huntington's Disease, traumatic brain injury, and other neuronal dysfunctions. However, the use of these antioxidants in the management of neurodegenerative conditions has so far been not well understood. This is a comprehensive collection addressing the effects on the brain of natural products and edible items such as reservatrol, curcumin, gingerol, fruits, vegetables, nuts, and marine products.