Dissertation Abstracts International
Author:
Publisher:
Published: 2006
Total Pages: 860
ISBN-13:
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Dna Polymerases: Discovery, Characterization And Functions In Cellular Dna Transactions
Author: Ulrich Hubscher
Publisher: World Scientific
Published: 2010-04-14
Total Pages: 338
ISBN-13: 9814465453
DOWNLOAD EBOOKMaintenance of the information embedded in the genomic DNA sequence is essential for life. DNA polymerases play pivotal roles in the complex processes that maintain genetic integrity. Besides their tasks in vivo, DNA polymerases are the workhorses in numerous biotechnology applications such as the polymerase chain reaction (PCR), cDNA cloning, genome sequencing, nucleic acids-based diagnostics and in techniques to analyze ancient and otherwise damaged DNA. Moreover, some diseases are related to DNA polymerase defects, and chemotherapy through inhibition of DNA polymerases is used to fight HIV, Herpes and Hepatitis B and C infections. We have recently witnessed the discovery of an abundance of novel DNA polymerases in viruses, bacteria, archaea and eukaryotes with specialized properties whose physiological functions are only beginning to be understood. This book summarizes the current knowledge of these fascinating enzymes. It is intended for a wide audience from basic scientists, to diagnostic laboratories and to clinicians who seek a better understanding of these fascinating enzymes.
New Trends in Genetic Risk Assessment
Author: G. Jolles
Publisher: Academic Press
Published: 2013-10-22
Total Pages: 513
ISBN-13: 1483265676
DOWNLOAD EBOOKNew Trends in Genetic Risk Assessment is based on the Fifth International Round Table of the Rhône-Poulenc Santé Foundation, held in Nice 1987. The conference was an attempt to review the latest theories and mechanisms stipulated for the various aspects of genotoxicity; it was above all an open forum to discuss the new trends, the new tests, and the new battery of tests for assessing the genetic risk of chemicals and especially drugs. This volume is actually not a proceedings of the meeting but a monograph specially edited to report the reviews which were presented and the discussions which took place; it was designed to provide a better understanding of the knowledge obtained in the most recent years and to help in the practical choice of approaches or tests for the prediction of the various forms of genotoxicity. The main subjects of this review concern molecular analysis of mutagenesis, detection of DNA damage, gene mutation, clastogenesis, aneuploidy, and germ cells. Each theme is preceded by a short overview summarizing the state of the art and the contributions of each author. Finally, special attention was given to the personal views of some leading toxicologists as to the battery of tests presently available or recommended.
Index Medicus
Author:
Publisher:
Published: 2001-03
Total Pages: 1568
ISBN-13:
DOWNLOAD EBOOKVols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
DNA Repair and Mutagenesis
Author: Errol C. Friedberg
Publisher: American Society for Microbiology Press
Published: 2005-11-22
Total Pages: 2587
ISBN-13: 1555813194
DOWNLOAD EBOOKAn essential resource for all scientists researching cellular responses to DNA damage. • Introduces important new material reflective of the major changes and developments that have occurred in the field over the last decade. • Discussed the field within a strong historical framework, and all aspects of biological responses to DNA damage are detailed. • Provides information on covering sources and consequences of DNA damage; correcting altered bases in DNA: DNA repair; DNA damage tolerance and mutagenesis; regulatory responses to DNA damage in eukaryotes; and disease states associated with defective biological responses to DNA damage.
Cumulated Index Medicus
Author:
Publisher:
Published: 1975
Total Pages: 1448
ISBN-13:
DOWNLOAD EBOOKAmerican Doctoral Dissertations
Author:
Publisher:
Published: 1988
Total Pages: 728
ISBN-13:
DOWNLOAD EBOOKBiological Responses to DNA Damage
Author:
Publisher: CSHL Press
Published: 2000
Total Pages: 680
ISBN-13: 9780879696061
DOWNLOAD EBOOKLiving cells have evolved many ways of coping with metabolic events and environmental influences that damage DNA. These mechanisms, and the frequent progression to cancer that results when they go awry, are rev iewed in this volume by authors from over sixty of the world's leading laboratories. The topics discussed include DNA repair, mutagenesis and other damage-tolerance functions, checkpoint control, apoptosis, and adaptation. They draw from studies on human and yeast cells. Current, but with a valuable historical perspective, this volume has the depth and lasting value typical of this most prestigious series and is esse ntial reading for investigators of DNA replication, cell cycle control, and tumorigenesis.
Recombinational Repair of DNA Damage
Author: Andrei Kuzminov
Publisher: Landes Bioscience
Published: 1996
Total Pages: 234
ISBN-13:
DOWNLOAD EBOOKDna Repair, Genetic Instability, And Cancer
Author: Qingyi Wei
Publisher: World Scientific
Published: 2007-01-08
Total Pages: 374
ISBN-13: 9814477117
DOWNLOAD EBOOKThis volume describes the elaborate surveillance systems and various DNA repair mechanisms that ensure accurate passage of genetic information onto daughter cells. In particular, it narrates how the cell cycle checkpoint and DNA repair machineries detect and restore DNA damages that are embedded in millions to billions of normal base pairs. The scope of the book ranges from biochemical analyses and structural details of DNA repair proteins, to integrative genomics and population-based studies. It provides a snapshot of current understanding about some of the major DNA repair pathways, including base-excision repair, nucleotide excision repair, mismatch repair, homologous recombination, and non-homologous end-joining as well as cell cycle checkpoints and translesion DNA synthesis. One of the particular emphases of the book is the link between inherited DNA repair deficiencies and susceptibility to cancer in the general population. For the first time, the book brings together a collection of review articles written by a group of active and laboratory-based investigators who have a clear understanding of the recent advances in the fields of DNA damage repair and genomic stability and their implications in carcinogenesis, new approaches in cancer therapy, and cancer prevention.
