Hydrogen Peroxide Metabolism in Health and Disease
Hydrogen Peroxide Metabolism in Health and Disease

Author: Margreet C M Vissers

Publisher: CRC Press

Published: 2017-10-19

Total Pages: 456

ISBN-13: 1498776167

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Much of the biology of oxidative stress and oxidative signalling centres on the generation and handling of hydrogen peroxide. The overall aim for this book would be to provide an insightful and useful forum to assist with the understanding of the relevance of hydrogen peroxide generation and how this is managed in human biology. The target audience would be those who currently have an interest in the generation of ROS, but who do not have expertise in chemistry, as well as those experts in the chemistry of oxidative stress, but without detailed understanding of the biologically relevant setting. We would aim to bridge the gap in understanding between chemistry and biology.

General Methods in Biomarker Research and their Applications
General Methods in Biomarker Research and their Applications

Author: Victor R. Preedy

Publisher: Springer

Published: 2015-08-14

Total Pages: 0

ISBN-13: 9789400776951

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In the past decade there has been a major sea change in the way disease is diagnosed and investigated due to the advent of high throughput technologies, such as microarrays, lab on a chip, proteomics, genomics, lipomics, metabolomics etc. These advances have enabled the discovery of new and novel markers of disease relating to autoimmune disorders, cancers, endocrine diseases, genetic disorders, sensory damage, intestinal diseases etc. In many instances these developments have gone hand in hand with the discovery of biomarkers elucidated via traditional or conventional methods, such as histopathology or clinical biochemistry. Together with microprocessor-based data analysis, advanced statistics and bioinformatics these markers have been used to identify individuals with active disease or pathology as well as those who are refractory or have distinguishing pathologies. New analytical methods that have been used to identify markers of disease and is suggested that there may be as many as 40 different platforms. Unfortunately techniques and methods have not been readily transferable to other disease states and sometimes diagnosis still relies on single analytes rather than a cohort of markers. There is thus a demand for a comprehensive and focused evidenced-based text and scientific literature that addresses these issues. Hence the formulation of Biomarkers in Disease. The series covers a wide number of areas including for example, nutrition, cancer, endocrinology, cardiology, addictions, immunology, birth defects, genetics and so on. The chapters are written by national or international experts and specialists.

Oxygen, the Breath of Life: Boon and Bane in Human Health, Disease, and Therapy
Oxygen, the Breath of Life: Boon and Bane in Human Health, Disease, and Therapy

Author: Olen R. Brown

Publisher: Bentham Science Publishers

Published: 2017-03-07

Total Pages: 370

ISBN-13: 1681084252

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Oxygen is historically entwined from its discovery with radical applications as a panacea by charlatans and by daring men constructing bridges using underwater caissons. Oxygen has made possible the exploration of the depths of the oceans beginning with hard-hat diving suits and extending to scuba gear, underwater habitats and submarines as well as space exploration. Molecular oxygen is critically involved in health and disease in more ways than any other element. It is essential for metabolism of food to nourish our bodies. Understanding its biological and chemical nature helps us to understand the effects of exercise, vitamins and supplements, and drugs used for cancer therapies. Oxygen, the Breath of Life is a comprehensive reference on the historical, biological, chemical and medical aspects of oxygen. Readers, both laymen and experts, will gain knowledge of the basics of oxygen chemistry, how it functions in the human body, the role of oxidants in the development of various diseases. Chapters contain historical notes which highlight the discoveries of pioneering researchers.

Hydrogen Peroxide
Hydrogen Peroxide

Author: Phd Prof Randolph Michael Howes MD

Publisher: CreateSpace

Published: 2014-04-30

Total Pages: 492

ISBN-13: 9781497531758

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This book, Hydrogen Peroxide: A Health, Homeostatic and Protective Essentiality, verifies the crucial role of hydrogen peroxide, oxygen free radicals and electronically modified oxygen derivatives (EMODs) in healing, sexual function, reproduction, pathogen protection and cancer protection. Once again, we see that electronically modified oxygen derivatives (EMODs) are essential for homeostasis and normal functioning of the body and its organs. The fallen free radical theory has radically misled us many times for over half a century. Oxygen and its electronically modified oxygen derivative (EMOD) progeny are the sine qua non (the essential condition) of man's very existence. This is an inarguable fact. H2O2 is now recognized as a ubiquitous intracellular messenger under subtoxic conditions. Thus, get out of your head the concept that EMODs, and in particular hydrogen peroxide, are some cellular assassinating radical products generated only by angry PMNs. EMODs and hydrogen peroxide are intentionally generated salutary cellular products intended to help regulate critical metabolic and reproductive mechanisms. I believe that hydrogen peroxide is the most prevalent, and perhaps the most significant EMOD in the body, even exceeding the well recognized importance of nitric oxide. Hydrogen peroxide is ubiquitous, omnipresent and in steady state levels in all aerobic cells, due to its crucial protective role in sustaining and perpetuating mankind.

Free Radicals in Human Health and Disease
Free Radicals in Human Health and Disease

Author: Vibha Rani

Publisher: Springer

Published: 2014-11-14

Total Pages: 427

ISBN-13: 8132220358

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The role of oxidative stress in human disease has become an area of intense interest. Free radicals, a normal product of metabolism, exist in all aerobic cells in balance with biochemical antioxidants. Environmental stress increases the levels of free radicals drastically, thereby disturbing the equilibrium between free radical production and the antioxidant capability causing oxidative stress. Over the years, ROS has been implicated in the pathologies of various diseases like cancer, neurological disorder, cardiovascular diseases rheumatoid arthritis, diabetes etc. This book provides an in depth critical state-of-art reviews from established investigators on free radicals, ROS associated pathogenesis of human diseases, biomarkers of oxidative damage, antioxidants, phytonutrients and other related health concerns of modern society. The present book is aimed at graduate students, researchers in academia, industry and clinicians with the interest in redox biology. Special attention has been devoted to the topic of ROS signalling, oxidative stress induced human pathologies & antioxidative therapies. The book consists of four parts in specified topics based on the current literatures for the better understanding of the readers with respect to their subject-wise interests. The first section of the book provides an overview about the ROS production and their measuring tools and techniques followed by the mechanisms involved in the oxidative stress in the second section. The third section describes the involvement of oxidative stress in different human diseases and the last section focuses on the different strategies to ameliorate oxidative stress induced stress.

Dubois' Lupus Erythematosus and Related Syndromes - E-Book
Dubois' Lupus Erythematosus and Related Syndromes - E-Book

Author: Daniel Wallace

Publisher: Elsevier Health Sciences

Published: 2018-08-16

Total Pages: 752

ISBN-13: 0323550649

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For more than 50 years, Dubois’ Lupus Erythematosus and Related Syndromes has been recognized internationally as the go-to clinical reference on lupus and other connective tissue diseases. From basic scientific principles to practical points of clinical management, the updated 9th Edition provides extensive, authoritative coverage of systemic lupus erythematosus (SLE) and its related diseases in a logical, clearly written, user-friendly manner. It’s an ideal resource for rheumatologists and internal medicine practitioners who need a comprehensive clinical reference on all aspects of SLE, connective tissue diseases, and the antiphospholipid syndromes. Provides complete clinical coverage of every aspect of cutaneous and systemic lupus erythematosus, including definitions, pathogenesis, autoantibodies, clinical and laboratory features, management, prognosis, and patient education. Contains an up-to-date overview of significant advances in cellular, molecular, and genetic technologies, including genetic advancements in identifying at-risk patients. Offers an increased focus on the clinical management of related disorders such as Sjogren’s syndrome, scleroderma, polymyositis, and antiphospholipid syndrome (APS). Presents the knowledge and expertise of more international contributors to provide new global perspectives on manifestations, diagnosis, and treatment. Features a vibrant, full-color format, with graphs, algorithms, differential diagnosis comparisons, and more schematic diagrams throughout.

Biochemistry of Oxidative Stress
Biochemistry of Oxidative Stress

Author: Ricardo Jorge Gelpi

Publisher: Springer

Published: 2016-12-28

Total Pages: 448

ISBN-13: 3319458655

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The strongest point of this book titled “Biochemistry of Oxidative Stress: Physiopathology and Clinical Aspects”, is that the academic and scientific background of the authors/editors guarantee the authorship of a book comprising all aspects of oxidative stress, ranging from very molecular aspects, to clinical application, including the antioxidant therapy. Of particular importance is the fact that the aforementioned aspects are described in the book in a general section and in three different and important pathologies, such as cardiovascular diseases, neurodegenerative diseases, and cancer. The importance of these pathologies lays in the fact that, taken separately or together, they represent by far the leading cause of death in the world. Finally, all the chapters have been written by highly recognized authorities in the field of their investigations. At least to our knowledge, this is the first book with this characteristics in the field of oxidative stress.

Glutathione System and Oxidative Stress in Health and Disease
Glutathione System and Oxidative Stress in Health and Disease

Author:

Publisher: BoD – Books on Demand

Published: 2020-08-26

Total Pages: 140

ISBN-13: 1838801251

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The imbalance between the production of reactive oxygen species (ROS) and antioxidant defenses determines a state known as oxidative stress. Higher levels of pro-oxidants compared to antioxidant defenses may generate oxidative damage, which, in turn, may lead to modifications in cellular proteins, lipids, and DNA, reducing functional capacity and increasing the risk of diseases. Nevertheless, the clearance of harmful reactive chemical species is achieved by the antioxidant defense systems. These protection systems are referred to as the first and second lines of defense and comprise the classic antioxidants, enzymatic and nonenzymatic defenses, including glutathione. This book presents and discusses the advancement of research on health and diseases and their underlying mechanisms, exploring mainly aspects related to the glutathione antioxidant system.