Transcriptional Control of Neural Crest Development
Transcriptional Control of Neural Crest Development

Author: Brian L. Nelms

Publisher: Morgan & Claypool Publishers

Published: 2010

Total Pages: 227

ISBN-13: 161504048X

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The neural crest is a remarkable embryonic population of cells found only in vertebrates and has the potential to give rise to many different cell types contributing throughout the body. These derivatives range from the mesenchymal bone and cartilage comprising the facial skeleton, to neuronal derivatives of the peripheral sensory and autonomic nervous systems, to melanocytes throughout the body, and to smooth muscle of the great arteries of the heart. For these cells to correctly progress from an unspecifi ed, nonmigratory population to a wide array of dynamic, differentiated cell types-some of which retain stem cell characteristics presumably to replenish these derivatives-requires a complex network of molecular switches to control the gene programs giving these cells their defi ning structural, enzymatic, migratory, and signaling capacities. This review will bring together current knowledge of neural crest-specifi c transcription factors governing these progressions throughout the course of development. A more thorough understanding of the mechanisms of transcriptional control in differentiation will aid in strategies designed to push undifferentiated cells toward a particular lineage, and unraveling these processes will help toward reprogramming cells from a differentiated to a more naive state. Table of Contents: Introduction / AP Genes / bHLH Genes / ETS Genes / Fox Genes / Homeobox Genes / Hox Genes / Lim Genes / Pax Genes / POU Domain Genes / RAR/RXR Genes / Smad Genes / Sox Genes / Zinc Finger Genes / Other Miscellaneous Genes / References / Author Biographies

Patterning and Cell Type Specification in the Developing CNS and PNS
Patterning and Cell Type Specification in the Developing CNS and PNS

Author:

Publisher: Academic Press

Published: 2013-05-06

Total Pages: 993

ISBN-13: 0123973481

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The genetic, molecular, and cellular mechanisms of neural development are essential for understanding evolution and disorders of neural systems. Recent advances in genetic, molecular, and cell biological methods have generated a massive increase in new information, but there is a paucity of comprehensive and up-to-date syntheses, references, and historical perspectives on this important subject. The Comprehensive Developmental Neuroscience series is designed to fill this gap, offering the most thorough coverage of this field on the market today and addressing all aspects of how the nervous system and its components develop. Particular attention is paid to the effects of abnormal development and on new psychiatric/neurological treatments being developed based on our increased understanding of developmental mechanisms. Each volume in the series consists of review style articles that average 15-20pp and feature numerous illustrations and full references. Volume 1 offers 48 high level articles devoted mainly to patterning and cell type specification in the developing central and peripheral nervous systems. - Series offers 144 articles for 2904 full color pages addressing ways in which the nervous system and its components develop - Features leading experts in various subfields as Section Editors and article Authors - All articles peer reviewed by Section Editors to ensure accuracy, thoroughness, and scholarship - Volume 1 sections include coverage of mechanisms which: control regional specification, regulate proliferation of neuronal progenitors and control differentiation and survival of specific neuronal subtypes, and controlling development of non-neural cells

HOX Gene Expression
HOX Gene Expression

Author: Spyros Papageorgiou

Publisher: Springer Science & Business Media

Published: 2007-08-28

Total Pages: 158

ISBN-13: 0387689907

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Hox Gene Expression starts with the amazing discovery of the homeobox twenty-three years ago and follows the exciting path thereafter of a series of breakthroughs in Genetics, Development and Evolution. It deals with homeotic genes, their evolution, structure, normal and abnormal function. Researchers and graduate students in biology and medicine will benefit from this integrated overview of Hox gene activities.

Guidebook to the Homeobox Genes
Guidebook to the Homeobox Genes

Author: Denis Duboule

Publisher:

Published: 1994

Total Pages: 306

ISBN-13:

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This much-needed guidebook provides research workers with the most up-to-date reference available on homeobox genes. As the tenth anniversary of the discovery of the homeobox fast approaches, these genes are being isolated from an ever-widening group of organisms and are now understood as critical to numerous developmental processes. But the rapidly increasing pool of information on homeobox genes has often resulted in a lack of coordination in the use of nomenclature and classification systems. As a result, the field has been sometimes characterized by its confusing and scattered literature. This book provides an overview of the subject by summarizing the dispersed findings and by listing key references. The first two chapters give a brief historical account of the discovery of the homeobox and introduce the reader to its role in development. The third chapter provides comprehensive coverage to the classification and structural organization of the homeobox genes. Finally, short descriptions of individual homeobox genes are provided in alphabetical order at the end of the book. Guidebook to the Homeobox Genes, with its easy-to-use format, offers a quick and simple way to learn about the essentials of each gene with cogent descriptions and helpful references . It will be welcomed by students and professionals in developmental biology, molecular genetics, and molecular biology.

Endless Forms Most Beautiful
Endless Forms Most Beautiful

Author: Sean B. Carroll

Publisher: W. W. Norton & Company

Published: 2005

Total Pages: 388

ISBN-13: 9780393060164

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As described in this fascinating book, Evo Devo is evolutionary development biology, the third revolution in the science, which shows how the endless forms of animals--butterflies and zebras, trilobites and dinosaurs, apes and humans--were made and evolved.

The Regulatory Genome
The Regulatory Genome

Author: Eric H. Davidson

Publisher: Elsevier

Published: 2010-07-19

Total Pages: 303

ISBN-13: 0080455573

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Gene regulatory networks are the most complex, extensive control systems found in nature. The interaction between biology and evolution has been the subject of great interest in recent years. The author, Eric Davidson, has been instrumental in elucidating this relationship. He is a world renowned scientist and a major contributor to the field of developmental biology. The Regulatory Genome beautifully explains the control of animal development in terms of structure/function relations of inherited regulatory DNA sequence, and the emergent properties of the gene regulatory networks composed of these sequences. New insights into the mechanisms of body plan evolution are derived from considerations of the consequences of change in developmental gene regulatory networks. Examples of crucial evidence underscore each major concept. The clear writing style explains regulatory causality without requiring a sophisticated background in descriptive developmental biology. This unique text supersedes anything currently available in the market. - The only book in the market that is solely devoted to the genomic regulatory code for animal development - Written at a conceptual level, including many novel synthetic concepts that ultimately simplify understanding - Presents a comprehensive treatment of molecular control elements that determine the function of genes - Provides a comparative treatment of development, based on principles rather than description of developmental processes - Considers the evolutionary processes in terms of the structural properties of gene regulatory networks - Includes 42 full-color descriptive figures and diagrams

Evolutionary Developmental Biology of Crustacea
Evolutionary Developmental Biology of Crustacea

Author: Gerhard Scholtz

Publisher: CRC Press

Published: 2003-06-01

Total Pages: 324

ISBN-13: 9789058096371

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Crustaceans, due to the great diversity of their body organization, segmentation patterns, tagmatization, limb types, larval forms, cleavage, and gastrulation modes, are highly desirable for the study of questions at the interface of evolution and development. Modern interest in evolutionary developmental biology (evo-devo) rests on the molecular genetic approach and a variety of molecular techniques have proven fruitful when performed on crustaceans. Evolutionary Developmental Biology of Crustacea presents a comprehensive treatment of all aspects of the field, beginning with a discussion of the implications of the typological Bauplan and phylum concepts versus historical concepts such as ground pattern and monophylum for the formulation of conceptual questions in evo-devo. Following this, the authors present the results of Hox gene expression in various crustacean taxa, aspects of segment formation at the cellular and genetic levels, the formation of segmental structures such as neurons, ganglia, and limbs, and the role of morphological ontogenetic characters in resolving phylogenetic relationships. By covering so many general aspects of crustacean development, morphology, and evolution, Evolutionary Developmental Biology of Crustacea serves as an indispensable reference for developmental and evolutionary biologists investigating the role of genetics in evolution and development.

Principles of Developmental Genetics
Principles of Developmental Genetics

Author: Sally A. Moody

Publisher: Elsevier

Published: 2007-07-19

Total Pages: 1094

ISBN-13: 0080550711

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Unlike anything currently available in the market, Dr. Sally A. Moody and a team of world-renowned experts provide a groundbreaking view of developmental genetics that will influence scientific approaches in embryology, comparative biology, as well as the newly emerging fields of stem cell biology and regenerative medicine. Principles of Developmental Genetics highlights the intersection of developmental biology with new revolutionary genomic technologies, and details how these advances have accelerated our understanding of the molecular genetic processes that regulates development. This definitive resource provides researchers with the opportunity to gain important insights into the clinical applicability of emerging new technologies and animal model data. This book is a must-have for all researchers in genetics, developmental biology, regenerative medicine, and stem cell biology.• Includes new research not previously published in any other book on the molecular geneticprocesses that regulates development• Chapters present a broad understanding on the application of animal model systems, allowingresearchers to better treat clinical disorders and comprehend human development• Relates the application of new technologies to the manipulation of stem cells, causes ofhuman birth defects, and several human disease conditions• Each chapter includes a bulleted summary highlighting clinical aspects of animal models

The Neural Crest
The Neural Crest

Author: Nicole Le Douarin

Publisher: Cambridge University Press

Published: 1999-11-28

Total Pages: 494

ISBN-13: 9780521620109

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This 1999 edition of The Neural Crest contains comprehensive information about the neural crest, a structure unique to the vertebrate embryo, which has only a transient existence in early embryonic life. The ontogeny of the neural crest embodies the most important issues in developmental biology, as the neural crest is considered to have played a crucial role in evolution of the vertebrate phylum. Data that analyse neural crest ontogeny in murine and zebrafish embryos have been included in this revision. This revised edition also takes advantage of recent advances in our understanding of markers of neural crest cell subpopulations, and a full chapter is now devoted to cell lineage analysis. The major research breakthrough since the first edition has been the introduction of molecular biology to neural crest research, enabling an elucidation of many molecular mechanisms of neural crest development. This book is essential reading for students and researchers in developmental biology, cell biology, and neuroscience.

Hox Genes
Hox Genes

Author: Jean S. Deutsch

Publisher: Springer Science & Business Media

Published: 2011-01-11

Total Pages: 184

ISBN-13: 1441966730

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In his 1894 book, Materials for the Study of Variation, William Bateson coined the term Homoeosis with the following prose: The case of the modification of the antenna of an insect into a foot, of the eye of a Crustacean into an antenna, of a petal into a stamen, and the like, are examples of the same kind. It is desirable and indeed necessary that such Variations, which consist in the assumption by one member of a Meristic series, of the form or characters proper to other members of the series, should be recognized as constituting a distinct group of phenomena. ...I therefore propose...the term HOMOEOSIS...; for the essential phenomenon is not that there has merely been a change, but that something has been changed into the likeness of something else. The book was intended as a listing of the kinds of naturally occurring variation that could act as a substrate for the evolutionary process and Bateson took his examples from collections, both private and in museums, of materials displaying morphological oddities. Interestingly the person who also coined the term “Genetics” proffered little in the way of speculation on the possible genetic underpinnings of these oddities. It wasn’t until the early part of the next century that these changes in meristic series were shown to be heritable.