Host-Parasite Cellular and Molecular Interactions in Protozoal Infections
Host-Parasite Cellular and Molecular Interactions in Protozoal Infections

Author: K.-P. Chang

Publisher: Springer Science & Business Media

Published: 2013-06-29

Total Pages: 426

ISBN-13: 3642728405

DOWNLOAD EBOOK

Tropical diseases such as leishmaniasis, malaria. trypanosomiasis, toxoplasmosis and amebiasis continue to plague the world, resulting in considerable morbidity and mortality, especially in the third world countries. These diseases are caused by a group of protozoa which have, over the years, undergone evolutionary adaptation to live often intracellularly in a parasitic way of life. So well-adapted have they become that they recognize the right hosts or cells to parasitize, yet at the same time they escape recognition and destruction by the host immune system. The mechanisms of such recognition and the escape of recognition are governed largely by host-parasite surface membrane interactions at the cellular and molecular level. Unique molecules produced by unusual pathways of these parasites have also been discovered and found to play important roles in their survival in the host. Understanding these mechanisms and pathways is essential not only to formulate a rational strategy for chemo- and immuno-prophylaxis and -therapy but also to unravel the mystery of biological evolution in symbiosis and parasitism. In the advent of our knowledge on the molecular biology and biochemistry of parasite membrane and other molecules, it is opportune to examine and discuss their possible roles in host-parasite recognition and interaction in a comparative approach. To highlight the recent advances of this area in various host-parasite systems, a NATO advanced Research Workshop was held from September 27 to October 1, 1986 at Hotel Villa del Mare, Acquafredda di Maratea, Italy.

Molecular Mechanisms of Parasite Invasion
Molecular Mechanisms of Parasite Invasion

Author: Barbara A. Burleigh

Publisher: Springer Science & Business Media

Published: 2008-12-05

Total Pages: 255

ISBN-13: 0387782672

DOWNLOAD EBOOK

All of the parasitic organisms highlighted in this new book represent medically important human pathogens that contribute significantly to the global burden of disease. As such there is intense interest in understanding the molecular basis of infection by these pathogens—not only with regard to their clinical relevance but also the fascinating biology they reveal. For most of the parasites discussed here the ability to penetrate biological barriers and/or to establish intracellular residence is critical to survival of the pathogen in the mammalian hosts. For other parasites, a tissue invasive phenotype is a key virulence determinant. In the ensuing 18 chapters, select members of this diverse set of protozoan parasites, as well as some examples of the extremely reduced fungal parasites classified as Microsporidia, are discussed within the context of the fascinating molecular strategies employed by these organisms to migrate across biological barriers and to establish residence within target host cells.

Eukaryome Impact on Human Intestine Homeostasis and Mucosal Immunology
Eukaryome Impact on Human Intestine Homeostasis and Mucosal Immunology

Author: Nancy Guillen

Publisher: Springer Nature

Published: 2020-06-01

Total Pages: 368

ISBN-13: 3030448266

DOWNLOAD EBOOK

Multiple demographic or economic parameters contribute to the origin of emerging infections, for example: poverty, urbanization, climate change, conflicts and population migrations. All these factors are a challenge to assess the impact (present and future) of parasitic diseases on public health. The intestine is a major target of these infections; it is a nutrient-rich environment harbouring a complex and dynamic population of 100 trillion microbes: the microbiome. Most researches on the microbiome focus on bacteria, which share the gut ecosystem with a population of uni- and multi cellular eukaryotic organisms that may prey on them. Our interest focuses on the families of eukaryotic microbes inhabiting the intestine, called “intestinal eukaryome”, that include fungi, protists and helminths. Knowledge on the reciprocal influence between the microbiome and the eukaryome, and on their combined impact on homeostasis and intestinal diseases is scanty and can be considered as an important emerging field. Furthermore, the factors that differentiate pathogenic eukaryotes from commensals are still unknown. This book presents an overview of the science presented and discussed in the First Eukaryome Congress held from October 16th to 18th, 2019 at the Pasteur Institute in Paris. This book covers the following topics: Phylogenetic, prevalence, and diversity of intestinal eukaryotic microbes; and their (still enigmatic) historical evolution and potential contributions to mucosal immune homeostasis. Integrative biology to study the molecular cell biology of parasite-host interactions and the multiple parameters underlining the infectious process. The exploitation of tissue engineering and microfluidics to establish three-dimensional (3D) systems that help to understand homeostasis and pathological processes in the human intestine.

Biochemistry and Molecular Biology of Parasites
Biochemistry and Molecular Biology of Parasites

Author: Joseph Marr

Publisher: Elsevier

Published: 1995-09-06

Total Pages: 363

ISBN-13: 0080527884

DOWNLOAD EBOOK

The study of parasitic organisms at the molecular level has yielded fascinating new insights of great medical, social, and economical importance, and has pointed the way for the treatment and prevention of the diseases they cause. Biochemistry and Molecular Biology of Parasites presents an up-to-date account of this modern scientific discipline in a manner that allows and encourages the reader to place the biochemistry and molecular biology of these organisms in their biological context. The chapters are cross-referenced and grouped in an arrangement that provides a fully integrated whole, and permits the reader to create a composite of the biochemical function of these organisms.Individual chapter includes those devoted to metabolism, in both aerobic and anaerobic protozoa; antioxidant mechanisms; parasite surfaces; organelles; invasion mechanisms; and chemotherapy. The helminths are discussed not only from the point of view of their cellular biochemistry and metabolism, but also with respect to both their integrated functions such as neurochemistry, structure and functions of surfaces, and reproduction. Written by expert investigators, this book will be of interest to all experienced researchers, graduate students, and to the newcomer eager to become familiar with the biochemistry and molecular biology of parasites.

Host-Parasite Interactions
Host-Parasite Interactions

Author: Gert Flik

Publisher: Taylor & Francis

Published: 2004-07-01

Total Pages: 256

ISBN-13: 1135319782

DOWNLOAD EBOOK

This volume summarizes current research into the physiology and molecular biology of host-parasite interactions. Brought together by leading international experts in the field, the first section outlines fundamental processes, followed by specific examples in the concluding section. Covering a wide range of organisms, Host-Parasite Interactions is essential reading for researchers in the field.

Protozoa and Human Disease
Protozoa and Human Disease

Author: Mark F Wiser

Publisher: Garland Science

Published: 2010-11-18

Total Pages: 255

ISBN-13: 1136738169

DOWNLOAD EBOOK

Protozoa and Human Disease is a textbook on medically important protozoa and the diseases they cause for advanced undergraduate students, graduate students, and professionals. It combines a taxonomic and medical approach and is therefore suitable for a parasitology, microbiology, medical, and public health readership. In addition to the basics such as morphological features, life cycles, and the clinical manifestations of the diseases, topics like the molecular and immunological basis of pathogenesis, metabolic pathways, specialized subcellular structures, ecology of disease transmission, antigenic variation, and molecular epidemiology are discussed for many of the protozoan pathogens. At the end of the book is an extensive glos

Wildlife Disease Ecology
Wildlife Disease Ecology

Author: Kenneth Wilson

Publisher: Cambridge University Press

Published: 2019-11-14

Total Pages: 693

ISBN-13: 1107136563

DOWNLOAD EBOOK

Introduces readers to key case studies that illustrate how theory and data can be integrated to understand wildlife disease ecology.

Parasite Infections: From Experimental Models to Natural Systems
Parasite Infections: From Experimental Models to Natural Systems

Author: Toni Aebischer

Publisher: Frontiers Media SA

Published: 2018-07-06

Total Pages: 294

ISBN-13: 2889454851

DOWNLOAD EBOOK

Eukaryotic parasites (including parasitic protozoans, worms and arthropods) are more complex and heterogeneous organisms than pathogenic bacteria and viruses. This notion implies different evolutionary strategies of host exploitation. Typically, parasites establish long-term infections and induce relatively little mortality, as they often limit pathological changes by modulating host cells and downregulating adverse immune responses. Their pattern of distribution tends to be endemic rather than epidemic. Despite these seemingly benign traits, parasites usually cause substantial chronic morbidity, thus constituting an enormous socioeconomic burden in humans, particularly in resource poor countries, and in livestock worldwide. Parasite-induced fitness costs are an evolutionary force that can shape populations and contribute to species diversity. Therefore, a thorough understanding of parasites and parasitic diseases requires detailed knowledge of the respective biochemical, molecular and immunological aspects as well as of population genetics, epidemiology and ecology. This Research Topic (RT) bridges disciplines to connect molecular, immunological and wildlife aspects of parasitic infections. The RT puts emphases on four groups of parasites: Plasmodium, Toxoplasma, Giardia and intestinal helminths. Co-infections are also covered by the RT as they represent the most common form of parasite infections in wildlife and domestic animal populations. Within the four types of parasites the following topics are addressed: (1) Experimental models: hypothesis testing, translation and limits. (2) Critical appraisal of experimental models. (3) Natural systems: Technological advances for investigations in natural parasite-host systems and studies in natural systems. (4) The urgent need for better models and methods in natural parasite systems. Hence, the RT covers and illustrate by the means of four main parasitic infections the parasite-host system at the molecular, cellular and organismic level.