Genomic imprinting allows scientists to trace genes to the parent of origin. This volume presents a collection of 13 papers by David Haig (organisimic and evolutionary biology, Harvard U.) on genomic imprinting. He argues that our paternally and maternally active genes do not work in cooperation with each other and in fact are in competition. Each paper is followed by commentary by the author, providing background information and discussing developments since its publication. Annotation copyrighted by Book News Inc., Portland, OR.
This open access textbook leads the reader from basic concepts of chromatin structure and function and RNA mechanisms to the understanding of epigenetics, imprinting, regeneration and reprogramming. The textbook treats epigenetic phenomena in animals, as well as plants. Written by four internationally known experts and senior lecturers in this field, it provides a valuable tool for Master- and PhD- students who need to comprehend the principles of epigenetics, or wish to gain a deeper knowledge in this field. After reading this book, the student will: Have an understanding of the basic toolbox of epigenetic regulation Know how genetic and epigenetic information layers are interconnected Be able to explain complex epigenetic phenomena by understanding the structures and principles of the underlying molecular mechanisms Understand how misregulated epigenetic mechanisms can lead to disease
Chromosomes Today, Volume 13 includes the plenary lectures presented at the 13th International Chromosome Conference, covering the most recent advances in the studies on chromosomes. The contributions in this volume were presented by some of the world's leaders in cytogenetic and molecular research and outline the present status of knowledge on the composition, structure, function and evolution of chromosomes, including, among others, the advancement of the human genome project. The use of cytogenetic studies has greatly increased in the last few years, resulting in a progressive improvement in the available methods that has consequently allowed a more detailed analysis of the molecular organization of eukaryotic chromosomes and a precise in situ localisation of specific gene sequences. This volume of Chromosomes Today provides up-to-date information regarding the topics at the forefront of chromosome research: genetic regulation, imprinting, DNA duplication, meiotic pairing, and the regulation of the...
In evolution, most genes survive and spread within populations because they increase the ability of their hosts (or their close relatives) to survive and reproduce. But some genes spread in spite of being harmful to the host organism—by distorting their own transmission to the next generation, or by changing how the host behaves toward relatives. As a consequence, different genes in a single organism can have diametrically opposed interests and adaptations.Covering all species from yeast to humans, Genes in Conflict is the first book to tell the story of selfish genetic elements, those continually appearing stretches of DNA that act narrowly to advance their own replication at the expense of the larger organism. As Austin Burt and Robert Trivers show, these selfish genes are a universal feature of life with pervasive effects, including numerous counter-adaptations. Their spread has created a whole world of socio-genetic interactions within individuals, usually completely hidden from sight.Genes in Conflict introduces the subject of selfish genetic elements in all its aspects, from molecular and genetic to behavioral and evolutionary. Burt and Trivers give us access for the first time to a crucial area of research—now developing at an explosive rate—that is cohering as a unitary whole, with its own logic and interconnected questions, a subject certain to be of enduring importance to our understanding of genetics and evolution.
Developmental programming is a rapidly advancing discipline of great importance to basic scientists and health professionals alike. This text integrates, for the first time, contributions from world experts to explore the role of the placenta in developmental programming. The book considers the materno-fetal supply line, and how perturbations of placental development impact on its functional capacity. Chapters examine ways in which environmental, immunological and vascular insults regulate expression of conventional and imprinted genes, along with their impact on placental shape and size, transport, metabolism and endocrine function. Research in animal models is integrated with human clinical and epidemiological data, and questions for future research are identified. Transcripts of discussions between the authors allow readers to engage with controversial issues. Essential reading for researchers in placental biology and developmental programming, as well as specialists and trainees in the wider field of reproductive medicine.
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Handbook of Epigenetics: The New Molecular and Medical Genetics, Second Edition, provides a comprehensive analysis of epigenetics, from basic biology, to clinical application. Epigenetics is considered by many to be the new genetics in that many biological phenomena are controlled, not through gene mutations, but rather through reversible and heritable epigenetic processes. These epigenetic processes range from DNA methylation to prions. The biological processes impacted by epigenetics are vast and encompass effects in lower organisms and humans that include tissue and organ regeneration, X-chromosome inactivation, stem cell differentiation, genomic imprinting, and aging. The first edition of this important work received excellent reviews; the second edition continues its comprehensive coverage adding more current research and new topics based on customer and reader reviews, including new discoveries, approved therapeutics, and clinical trials. From molecular mechanisms and epigenetic technology, to discoveries in human disease and clinical epigenetics, the nature and applications of the science is presented for those with interests ranging from the fundamental basis of epigenetics, to therapeutic interventions for epigenetic-based disorders. - Timely and comprehensive collection of fully up-to-date reviews on epigenetics that are organized into one volume and written by leading figures in the field - Covers the latest advances in many different areas of epigenetics, ranging from basic aspects, to technologies, to clinical medicine - Written at a verbal and technical level that can be understood by scientists and college students - Updated to include new epigenetic discoveries, newly approved therapeutics, and clinical trials
This classic work on the rules of sex -- updated for a new generation -- is still as provocative as the day it was published, providing simple explanations for any and all questions about what happens in the bedroom. Sex isn't as complicated as we make it. In Sperm Wars, evolutionary biologist Robin Baker argues that every question about human sexuality can be explained by one simple thing: sperm warfare. In the interest of promoting competition between sperm to fertilize the same egg, evolution has built men to conquer and monopolize women while women are built to seek the best genetic input on offer from potential sexual partners. Baker reveals, through a series of provocative fictional scene, the far-reaching implications of sperm competition. 10% of children are not fathered by their "fathers;" over 99% of a man's sperm exists simply to fight off all other men's sperm; and a woman is far more likely to conceive through a casual fling than through sex with her regular partner. From infidelity, to homosexuality, to the female orgasm, Sperm Wars turns on every light in the bedroom. Now with new material reflecting the latest research on sperm warfare, this milestone of popular science will still surprise, entertain, and even shock.
Kinship ties-the close relationships found within the family-have been a central focus of evolutionary biological analyses of social behavior ever since biologist William Hamilton extended the concept of Darwinian fitness to include an individual's actions benefiting not only his own offspring, but also collateral kin. Evolutionary biologists consider organisms not only reproductive strategists, but also nepotistic strategists. If a person's genes are just as likely to be reproduced in her sister as in her daughter, then we should expect the evolution of sororal investment in the same way as one expects maternal investment. This concept has revolutionized biologists' understanding of social interaction and developmental psychologists' understanding of the family. However, kinship ties have largely been ignored in other areas of psychology, particularly social psychology. Family Relationships brings together leading theorists and researchers from evolutionary psychology and related disciplines to illustrate the ways in which an evolutionary perspective can inform our study and understanding of family relationships. The contributors argue that family psychology is relationship specific: the relationship between mother and daughter is different from that between father and daughter or that between brother and sister or sister and sister. In other words, humans have evolved specialized mechanisms for processing information and motivating behavior that deal with the distinct demands of being a mate, father, mother, sibling, child, or grandparent. Such an evolutionary perspective on family dynamics provides a unique insight into human behavior. This volume will be an indispensable resource for psychologists, sociologists, and anthropologists, as well scholars of family, marriage, and animal behavior.
This latest volume in Advances in Genetics covers the genetics of Circadian rhythms. With an international group of authors this volume is the latest offering in this widely praised series.
