Genetics of the Immune Response
Genetics of the Immune Response

Author: Erna Moller

Publisher: Springer Science & Business Media

Published: 2013-03-08

Total Pages: 308

ISBN-13: 1468444697

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The 55th Nobel Symposium entitled "Genetics of the Immune Response" took place in Saltsjobaden, Sweden, June 15 - 17, 1982. The topic was selected for several reasons, such as the rapid progress in the genetic analysis of immunoglobulin and MHC genes and the elucidation of the mechanism of switch to different immunoglobulin classes and subclasses. The genetic advances formed a basis for discussions of problems relating to regulation of T cell subsets, mechanisms of activation and regulation of B cell differentiation and an analysis of the network hypothesis. The format of the symposium was arranged so as to include two sessions in the morning and two in the afternoon. Each session was introduced by one speaker, followed by free discussion. The intro ductory lectures are included in the proceedings. The participants summarized their contributions to the discussion in written form. In addi tion to the closed sessions, there was one open session at the Karolinska Institute with lectures by Drs. L. Hood, C. Milstein, D. Baltimore, J. Klein and B. Benacerraf, which are not included in these procee din gs. The symposium was sponsored by the Nobel Foundation and its Nobel Symposium Committee through grants from the Tercentenary Fund of the Bank of Sweden and the Knut & Alice Wallenberg Foundation. The Swedish Medical Research Council, the Swedish Cancer Society and the Swedish Ministry of Education and Cultural Affairs also made contri butions.

The Immune System
The Immune System

Author: Eli E. Sercarz

Publisher: Elsevier

Published: 2013-09-11

Total Pages: 657

ISBN-13: 1483277402

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The Immune System: Genes Receptors, Signals provides information pertinent to the complexity of immune mechanisms. This book describes the immune response genes and products, which point to another multigene system controlling immune responsiveness. Organized into 37 chapters, this book begins with an overview of the details of antibody structure that continue to be of importance to an understanding of the regulation of the immune reactions. This text then examines the evidence that individual antibody species are capable of binding many structurally dissimilar haptens. Other chapters consider the conceptual framework generally accepted by immunologists, which states that antibodies are specific for the antigen used to elicit the immune response. This book discusses as well the mechanism underlying the biosynthesis of antibody binding sites, which is unprecedented in its adaptability. The final chapter deals with the genetic controls of specific immune responses. This book is a valuable resource for immunologists and research workers.

Janeway's Immunobiology
Janeway's Immunobiology

Author: Kenneth Murphy

Publisher: Garland Science

Published: 2010-06-22

Total Pages:

ISBN-13: 9780815344575

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The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.

Handbook of Immune Response Genes
Handbook of Immune Response Genes

Author: Tak W. Mak

Publisher: Springer Science & Business Media

Published: 2007-07-27

Total Pages: 402

ISBN-13: 0585311803

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The study of immunology encompasses a vast and ever-growing body of information that in some way or other incorporates most areas of medical biological research. As the body of information in the medical sciences continues to increase its rate of expansion, one of the greatest challenges to investigators will be to integrate this information in a manner that is intellectually fruitful and productive. Considering the intended scope of this text, we could not pretend to have gone too far toward achieving such an integration--and considering the pace of change, in its very best form a measured approximation of such lofty goals might be the most we could hope for. Nevertheless, in these pages we have sought to produce a collection of information that is at once concise and up-to-date regarding areas where important developments are impacting on the way we understand the vertebrate immune system. In addition, although the information is geared toward advanced study, we have discussed some basic elements and concepts that we hope make the text a useful resource for both the immunologist and the nonspecialist. The intention is to provide the researcher, clinician, or advanced undergraduate student with a brief ov- view of specific components of the immune system, and to provide a place from which to begin further detailed study if necessary. To this end, we made every effort to supply extensive referencing--although limitations in space prevented exhaustive or complete referencing in some cases.

Genetic Control of Immune Responsiveness
Genetic Control of Immune Responsiveness

Author: Hugh Mcdevitt

Publisher: Academic Press

Published: 2012-12-02

Total Pages: 490

ISBN-13: 0323148255

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Genetic Control of Immune Responsiveness: Relationship to Disease Susceptibility documents the proceedings of an international conference held at Brook Lodge, Augusta, Michigan, May 8-10, 1972. It brings together the detailed experimental evidence on the mechanism of action of specific immune response genes, and shows how the two major classes of immune response genes affect our understanding of basic immunology and antibody formation on the one hand, and of host factors determining disease susceptibility on the other. The book is organized into seven parts that correspond to the seven sessions of the conference. Part I presents a session on how the study of the genetic control of immune responses in guinea pigs and mice has contributed to the development of T cell immunology. Part II presents a session on genetic fine structure of the major (H-2) histocompatibility complex in the mouse. Part III presents a session dealing with the association between the production of homogeneous antibody, or of idiotypic antibody, and immunoglobulin allotypes. Part IV presents a session on the relationship between histocompatibility-linked and allotype-linked immune response genes and antigen-specific receptors on T and B cells. Part V presents a session on animal models of multigenic control of susceptibility to disease. Part VI presents a session on the associations between HL-A type and specific disease entities. Finally, Part VII provides a commentary on the ideas and concepts emerging from the three days of free-ranging discussion.

Biological Regulation and Development
Biological Regulation and Development

Author: Robert F. Goldberger

Publisher: Springer Science & Business Media

Published: 2013-11-21

Total Pages: 318

ISBN-13: 1475746199

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The motivation for us to conceive this series of volumes on regulation was mainly our belief that it would be fun, and at the same time productive, to approach the subject in a way that differs from that of other treatises. We thought it might be interesting and instructive for both author and reader-to examine a particular area of investigation in a framework of many different problems. Cutting across the traditional boundaries that have separated the subjects in past volumes on regulation is not an easy thing to do-not because it is difficult to think of what interesting topics should replace the old ones, but because it is difficult to find authors who are willing to write about areas outside those pursued in their own laboratories. Anyone who takes on the task of reviewing a broad area of interest must weave together its various parts by picking up the threads from many different laboratories, and attempt to produce a fabric with a meaningful design. Finding persons who are likely to succeed in such a task was the most difficult part of our job. In the first volume of this treatise, most of the chapters dealt with the mechanisms of The second volume involved a somewhat regulation of gene expression in microorganisms. broader area, spanning the prokaryotic-eukaryotic border. Topics ranged from phage mor phogenesis to the role of gradients in development. The last volume-Volume 3A-con cerned hormones, as does this volume-Volume 3B.