This is a clear and informative guide to the genetics debate. Essential reading for anyone interested in the ethical implications of genetics and the future of biotechnology.
The ethics of creating -- or declining to create -- human beings has been addressed in several contexts: debates over abortion and embryo research; literature on "self-creation"; and discussions of procreative rights and responsibilities, genetic engineering, and future generations. Here, for the first time, is a sustained, scholarly analysis of all of these issues -- a discussion combining breadth of topics with philosophical depth, imagination with current scientific understanding, argumentative rigor with accessibility. The overarching aim of Creation Ethics is to illuminate a broad array of issues connected with reproduction and genetics, through the lens of moral philosophy. With novel frameworks for understanding prenatal moral status and human identity, and exceptional fairness to those holding different views, David DeGrazia sheds new light on the ethics of abortion and embryo research, genetic enhancement and prenatal genetic interventions, procreation and parenting, and decisions that affect the quality of life of future generations. Along the way, he helpfully introduces personal identity theory and value theory as well as such complex topics as moral status, wrongful life, and the "nonidentity problem." The results include a subjective account of human well-being, a standard for responsible procreation and parenting, and a theoretical bridge between consequentialist and nonconsequentialist ethical theories. The upshot is a synoptic, mostly liberal vision of the ethics of creating human beings.
In this introduction to philosophy of biology, Kim Sterelny and Paul E. Griffiths present both the science and the philosophical context necessary for a critical understanding of the debates shaping biology at the end of the 20th century.
Epigenetics is currently one of the fastest-growing fields in the sciences. Epigenetic information not only controls DNA expression but links genetic factors with the environmental experiences that influence the traits and characteristics of an individual. What we eat, where we work, and how we live affects not only the activity of our genes but that of our offspring as well. This discovery has imposed a revolutionary theoretical shift on modern biology, especially on evolutionary theory. It has helped to uncover the developmental processes leading to cancer, obesity, schizophrenia, alcoholism, and aging, and to facilitate associated medial applications such as stem cell therapy and cloning. Above the Gene, Beyond Biology explores how biologists in this booming field investigate and explain living systems. Jan Baedke offers the first comprehensive philosophical discussion of epigenetic concepts, explanations, and methodologies so that we can better understand this “epigenetic turn” in the life sciences from a philosophical perspective.
In light of scientific advances such as genomics, predictive diagnostics, genetically engineered agriculture, nuclear transfer cloning, and the manipulation of stem cells, the idea that genes carry predetermined molecular programs or blueprints is pervasive. Yet new scientific discoveries—such as rna transcripts of single genes that can lead to the production of different compounds from the same pieces of dna—challenge the concept of the gene alone as the dominant factor in biological development. Increasingly aware of the tension between certain empirical results and interpretations of those results based on the orthodox view of genetic determinism, a growing number of scientists urge a rethinking of what a gene is and how it works. In this collection, a group of internationally renowned scientists present some prominent alternative approaches to understanding the role of dna in the construction and function of biological organisms. Contributors discuss alternatives to the programmatic view of dna, including the developmental systems approach, methodical culturalism, the molecular process concept of the gene, the hermeneutic theory of description, and process structuralist biology. None of the approaches cast doubt on the notion that dna is tremendously important to biological life on earth; rather, contributors examine different ideas of how dna should be represented, evaluated, and explained. Just as ideas about genetic codes have reached far beyond the realm of science, the reconceptualizations of genetic theory in this volume have broad implications for ethics, philosophy, and the social sciences. Contributors. Thomas Bürglin, Brian C. Goodwin, James Griesemer, Paul Griffiths, Jesper Hoffmeyer, Evelyn Fox Keller, Gerd B. Müller, Eva M. Neumann-Held, Stuart A. Newman, Susan Oyama, Christoph Rehmann-Sutter, Sahotra Sarkar, Jackie Leach Scully, Gerry Webster, Ulrich Wolf
A proposal for a new model of the evolution of gene regulation networks and development that draws on work from artificial intelligence and philosophy of mind. Each of us is a collection of more than ten trillion cells, busy performing tasks crucial to our continued existence. Gene regulation networks, consisting of a subset of genes called transcription factors, control cellular activity, producing the right gene activities for the many situations that the multiplicity of cells in our bodies face. Genes working together make up a truly ingenious system. In this book, Roger Sansom investigates how gene regulation works and how such a refined but simple system evolved. Sansom describes in detail two frameworks for understanding gene regulation. The first, developed by the theoretical biologist Stuart Kauffman, holds that gene regulation networks are fundamentally systems that repeat patterns of gene expression. Sansom finds Kauffman's framework an inadequate explanation for how cells overcome the difficulty of development. Sansom proposes an alternative: the connectionist framework. Drawing on work from artificial intelligence and philosophy of mind, he argues that the key lies in how multiple transcription factors combine to regulate a single gene, acting in a way that is qualitatively consistent. This allows the expression of genes to be finely tuned to the variable microenvironments of cells. Because of the nature of both development and its evolution, we can gain insight into the developmental process when we identify gene regulation networks as the controllers of development. The ingenuity of genes is explained by how gene regulation networks evolve to control development.
By combining excerpts from key historical writings with editors’ introductions and further reading material, Philosophy of Biology: An Anthology offers a comprehensive, accessible, and up-to-date collection of the field’s most significant works. Addresses central questions such as ‘What is life?’ and ‘How did it begin?’, and the most current research and arguments on evolution and developmental biology Editorial notes throughout the text define, clarify, and qualify ideas, concepts and arguments Includes material on evolutionary psychology and evolutionary developmental biology not found in other standard philosophy of biology anthologies Further reading material assists novices in delving deeper into research in philosophy of biology
This interdisciplinary volume reflects on the effects of recent discoveries in genetics on a broad range of scientific fields. It shows the way in which those discoveries influence genetics itself and many other fields, and explains the impact of genetics on contemporary culture. The volume contains the most recent views of the Nobel Laureate François Jacob on genetics and the nature of living things.
A COMPANION TO THE PHILOSOPHY OF BIOLOGY “Sarkar is to be congratulated for assembling this talented team of philosophers, who are themselves to be congratulated for writing these interesting essays on so many fascinating areas in philosophy of biology. This book will be a wonderful resource for future work.” Elliot Sober, University of Wisconsin-Madison “Many of the discussions here start with a definition of terms and a historical context of the subject before delving into the deeper philosophical issues, making it a useful reference for students of biology as well as philosophy.” Northeastern Naturalist “The topics that are addressed are done so well. This book will appeal to the advanced student and knowledgeable amateur and may prove useful catalyst for discussion among research teams or those engaged in cross-disciplinary studies.” Reference Reviews A Companion to the Philosophy of Biology offers concise overviews of philosophical issues raised by all areas of biology. Addressing both traditional and emerging areas of philosophical interest, the volume focuses on the philosophical implications of evolutionary theory as well as key topics such as molecular biology, immunology, and ecology Comprising essays by top scholars in the field, this volume is an authoritative guide for professional philosophers, historians, sociologists and biologists, as well as an accessible reference work for students seeking to learn about this rapidly-changing field.