Gene regulation of fungal secondary metabolism
Author: Wenbing Yin
Publisher: Frontiers Media SA
Published: 2023-09-08
Total Pages: 147
ISBN-13: 283253371X
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Fungal Jewels: Secondary Metabolites
Author: Nancy Keller
Publisher: Frontiers Media SA
Published: 2017-04-10
Total Pages: 205
ISBN-13: 2889451364
DOWNLOAD EBOOKFungal natural products are friends and foes of humans such as deleterious mycotoxins, cytotoxic, carcinogenic compounds or beneficial compounds such as antibiotics, fungicides, insecticides, antiviral and antitumor metabolites. Understanding fungal diversity and estimation of fungal species on our planet poses a great challenge to researchers. This complexity is further multiplied by secondary metabolite diversity of fungi, which requires interdisciplinary studies. It is extremely important to understand the fungal secondary metabolism to stop human, animal and plant diseases caused by fungi and harvest their valuable metabolites. Furthermore, many secondary metabolite gene clusters are silenced under laboratory conditions. It is vital to develop effective methods to activate those clusters in order to discover novel potent metabolites. This e-book is a compilation of original review articles contributed by leading fungal secondary metabolite researchers with a wide range of expertise. Important aspects of fungal secondary metabolism, including regulation, genome mining, evolution, synthetic biology and novel methods have been discussed. This book will be a great source to those people, who are interested in understanding overall structure, diversity and regulation of production of these tiny but precious chemicals.
Biosynthesis and Molecular Genetics of Fungal Secondary Metabolites, Volume 2
Author: Susanne Zeilinger
Publisher: Springer
Published: 2015-06-15
Total Pages: 263
ISBN-13: 1493925318
DOWNLOAD EBOOKFungi produce many chemically diverse secondary metabolites whose biological roles largely remain elusive. Within the increasing number of sequenced fungal genomes several important genes involved in secondary metabolite formation have been identified. Most of these genes are clustered and their coordinated transcription is controlled in a complex way by both narrow pathway-specific regulators as well as broad global transcription factors responsive to environmental cues. In recent years it was discovered many of the newly identified gene clusters are silent under laboratory conditions suggesting that the biosynthetic potential of fungi is far from being exploited. Besides identifying novel bioactive metabolites from still unexplored sources, the activation of these gene clusters by several approaches may result in the discovery of new substances with antibiotic and pharmaceutical benefits. This book covers recent advances in the field of fungal secondary metabolisms ranging from methodologies to biological aspects and will include the latest knowledge on fungal molecular biology, genomics, and metabolomics. With the related volume by Professor Juan-Francisco Martin, where the most relevant and well-studied fungal secondary metabolites are compiled, this book provides a comprehensive overview of the state-of-the-art of research on fungal secondary metabolites.
Biosynthesis and Molecular Genetics of Fungal Secondary Metabolites
Author: Juan-Francisco Martín
Publisher: Springer
Published: 2014-09-09
Total Pages: 357
ISBN-13: 1493911910
DOWNLOAD EBOOKThis volume describes the more relevant secondary metabolites of different fungi with current information on their biosynthesis and molecular genetics. Bolstered with color illustrations and photographs, the book describes the possible application of molecular genetics to directed strain improvement in great detail. The needs for future developments in this field are also discussed at length Written by authorities in the field, Biosynthesis and Molecular Genetics of Fungal Secondary Metabolites provides a cutting-edge perspective on fungal secondary metabolism and underlying genetics and is a valuable resource for scientists, researchers, and educators in the field of fungal biology.
Fungal Secondary Metabolism
Author: Nancy P. Keller
Publisher: Humana Press
Published: 2016-05-01
Total Pages: 302
ISBN-13: 9781493959600
DOWNLOAD EBOOKThis Methods in Molecular Biology volume provides key methodologies for accessing and exploiting natural product information provided by the genomes of filamentous fungi. Includes materials and reagents lists, step-by-step protocols and troubleshooting tips."
Gene Expression Systems in Fungi: Advancements and Applications
Author: Monika Schmoll
Publisher: Springer
Published: 2016-04-04
Total Pages: 505
ISBN-13: 3319279513
DOWNLOAD EBOOKBiotechnology has emerged as one of the key environmentally safe technologies for the future which enables use of biomass to develop novel smart materials and to replace oil derived products. Fungi are the most efficient producers of the enzymes needed for this purpose and in addition they produce a plethora of secondary metabolites, among which novel antibiotics can be found. Industrial application and exploitation of the metabolic capacities of fungi requires highly productive and robust gene expression systems, which can be achieved by selection of appropriate species and strain improvement. In this book we aim to summarize homologous and heterologous gene expression systems of fungi for production of enzymes and secondary metabolites. A broad overview on requirements, challenges and successful applications shall serve as a basis for further development of fungi as biotechnological workhorses in research and industry.
Effectors in Plant-Microbe Interactions
Author: Francis Martin
Publisher: John Wiley & Sons
Published: 2012-01-03
Total Pages: 442
ISBN-13: 0470958227
DOWNLOAD EBOOKPlants and microbes interact in a complex relationship that can have both harmful and beneficial impacts on both plant and microbial communities. Effectors, secreted microbial molecules that alter plant processes and facilitate colonization, are central to understanding the complicated interplay between plants and microbes. Effectors in Plant-Microbe Interactions unlocks the molecular basis of this important class of microbial molecules and describes their diverse and complex interactions with host plants. Effectors in Plant Microbe Interactions is divided into five sections that take stock of the current knowledge on effectors of plant-associated organisms. Coverage ranges from the impact of bacterial, fungal and oomycete effectors on plant immunity and high-throughput genomic analysis of effectors to the function and trafficking of these microbial molecules. The final section looks at effectors secreted by other eukaryotic microbes that are the focus of current and future research efforts. Written by leading international experts in plant-microbe interactions, Effectors in Plant Microbe Interactions, will be an essential volume for plant biologists, microbiologists, pathologists, and geneticists.
Microbial Technology for the Welfare of Society
Author: Pankaj Kumar Arora
Publisher: Springer Nature
Published: 2019-09-12
Total Pages: 341
ISBN-13: 981138844X
DOWNLOAD EBOOKThis book describes various aspects of modern microbiology including microbial enzymes, secondary metabolites, next-generation sequencing, microbial-based biopesticides, microbial-based cancer therapies, biodiesel, and microbial products from fermentation, biodegradation, bioremediation and wastewater treatment. Further, it explains how and why microbes play an important role in preserving the welfare of living beings and the environment. Many bacteria play a significant part in cleaning our environment by detoxifying various xenobiotic compounds, while several microbes produce secondary metabolites that are useful to human beings. The book is divided into 15 chapters that cover various aspects of microorganism-based biotechnology, including recent methodologies such as advanced molecular techniques, as well developments in classical microbiological techniques. The authors also explain how the latest and classical techniques are being used in modern-day microbial biotechnology. All chapters were written by experts from prominent universities, research laboratories, and institutes around the globe. Above all, they focus on recent advances in microbial technology that promote the welfare of living beings and the environment.
Secondary Metabolism and Differentiation in Fungi
Author: Bennett
Publisher: CRC Press
Published: 2020-11-25
Total Pages: 495
ISBN-13: 1000110311
DOWNLOAD EBOOKThe first source to unite secondary fungal metabolism and morphogenesis in one volume, Secondary Metabolism and Differentiation in Fungi treats biological systems as parts of a whole rather than as a series of individual elements, highlighting research in genetics, molecular biology, and ecology. Featuring the expertise of 19 international authorities, each chapter is a rich source of experimentation ideas. The book facilitates the application of novel techniques to existing problems in molecular mycology and explores potentials for major new research. This indispensable guide to a key scientific field benefits biologists, chemists, and other scientists.
Fungal Primary and Secondary Metabolism and its Importance for Virulence and Biomedical Applications
Author: Fernando Rodrigues
Publisher: Frontiers Media SA
Published: 2021-06-23
Total Pages: 164
ISBN-13: 2889668894
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