Mapping and Sequencing the Human Genome
Mapping and Sequencing the Human Genome

Author: National Research Council

Publisher: National Academies Press

Published: 1988-01-01

Total Pages: 128

ISBN-13: 0309038405

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There is growing enthusiasm in the scientific community about the prospect of mapping and sequencing the human genome, a monumental project that will have far-reaching consequences for medicine, biology, technology, and other fields. But how will such an effort be organized and funded? How will we develop the new technologies that are needed? What new legal, social, and ethical questions will be raised? Mapping and Sequencing the Human Genome is a blueprint for this proposed project. The authors offer a highly readable explanation of the technical aspects of genetic mapping and sequencing, and they recommend specific interim and long-range research goals, organizational strategies, and funding levels. They also outline some of the legal and social questions that might arise and urge their early consideration by policymakers.

Genetic Mapping and Marker Assisted Selection
Genetic Mapping and Marker Assisted Selection

Author: N. Manikanda Boopathi

Publisher:

Published: 2020

Total Pages:

ISBN-13: 9789811529504

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This book details basics in genetic linkage mapping, step-by-step procedures to perform marker assisted selection (MAS), achievements made so far in different crops, and the limitations and prospects of MAS in plant breeding.

Gene-Mapping Techniques and Applications
Gene-Mapping Techniques and Applications

Author: Lawrence B. Schook

Publisher: CRC Press

Published: 2020-07-24

Total Pages: 353

ISBN-13: 100010463X

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This book explains current strategies for mapping genomes of higher organisms and explores applications of gene mapping to agriculturally important species of plants and animals. It also explores the experimental techniques used for genetic and physical mapping of genes.

The Statistics of Gene Mapping
The Statistics of Gene Mapping

Author: David Siegmund

Publisher: Springer Science & Business Media

Published: 2007-05-27

Total Pages: 337

ISBN-13: 0387496866

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This book details the statistical concepts used in gene mapping, first in the experimental context of crosses of inbred lines and then in outbred populations, primarily humans. It presents elementary principles of probability and statistics, which are implemented by computational tools based on the R programming language to simulate genetic experiments and evaluate statistical analyses. Each chapter contains exercises, both theoretical and computational, some routine and others that are more challenging. The R programming language is developed in the text.

Statistical Genetics
Statistical Genetics

Author: Benjamin Neale

Publisher: Garland Science

Published: 2007-11-30

Total Pages: 607

ISBN-13: 1134129335

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Statistical Genetics is an advanced textbook focusing on conducting genome-wide linkage and association analysis in order to identify the genes responsible for complex behaviors and diseases. Starting with an introductory section on statistics and quantitative genetics, it covers both established and new methodologies, providing the genetic and statistical theory on which they are based. Each chapter is written by leading researchers, who give the reader the benefit of their experience with worked examples, study design, and sources of error. The text can be used in conjunction with an associated website (www.genemapping.org) that provides supplementary material and links to downloadable software.

Mapping Fate
Mapping Fate

Author: Alice Wexler

Publisher: Univ of California Press

Published: 1996-12-30

Total Pages: 354

ISBN-13: 9780520207417

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Wexler tells the story of a family at risk for Huntington's disease, a hereditary, incurable, fatal disorder from which her own mother died. This graceful and eloquent account goes beyond the specifics of the disease to explore the dynamics of family secrets, of living at risk, and the drama and limits of biomedical research. Photos.

Genetic Mapping in Experimental Populations
Genetic Mapping in Experimental Populations

Author: J. W. Van Ooijen

Publisher: Cambridge University Press

Published: 2013-08-08

Total Pages: 171

ISBN-13: 1107013216

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A concise introduction to genetic linkage map construction for biological researchers, combining theory with practical exercises and problem-solving tips.

Human Chromosomes
Human Chromosomes

Author: Orlando J. Miller

Publisher: Springer Science & Business Media

Published: 2011-06-28

Total Pages: 508

ISBN-13: 1461301394

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The fourth edition of this well-known text provides students, researchers and technicians in the area of medicine, genetics and cell biology with a concise, understandable introduction to the structure and behavior of human chromosomes. This new edition continues to cover both basic and up-to-date material on normal and defective chromosomes, yet is particularly strengthened by the complete revision of the material on the molecular genetics of chromosomes and chromosomal defects. The mapping and molecular analysis of chromosomes is one of the most exciting and active areas of modern biomedical research, and this book will be invaluable to scientists, students, technicians and physicians with an interest in the function and dysfunction of chromosomes.

Analysis of Human Genetic Linkage
Analysis of Human Genetic Linkage

Author: Jurg Ott

Publisher: JHU Press

Published: 1999-04-16

Total Pages: 418

ISBN-13: 9780801861406

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Introduction and basic genetic principles; Genetic loci genetic polymorphisms; Aspects of statistical inference; Basics of linkage analysis; The informativeness of family data; Multipoint linkage analysis; Penetrance; Quantitative phenotypes; Numerical and computerized methods; Variability of the recombination fraction; Inconsistencies; Linkage analysis with mendelian disease loci; Nonparametric methods; Two-locus inheritance; Complex traits.

Phenotypes and Genotypes
Phenotypes and Genotypes

Author: Florian Frommlet

Publisher: Springer

Published: 2016-02-12

Total Pages: 232

ISBN-13: 1447153103

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This timely text presents a comprehensive guide to genetic association, a new and rapidly expanding field that aims to elucidate how our genetic code (genotypes) influences the traits we possess (phenotypes). The book provides a detailed review of methods of gene mapping used in association with experimental crosses, as well as genome-wide association studies. Emphasis is placed on model selection procedures for analyzing data from large-scale genome scans based on specifically designed modifications of the Bayesian information criterion. Features: presents a thorough introduction to the theoretical background to studies of genetic association (both genetic and statistical); reviews the latest advances in the field; illustrates the properties of methods for mapping quantitative trait loci using computer simulations and the analysis of real data; discusses open challenges; includes an extensive statistical appendix as a reference for those who are not totally familiar with the fundamentals of statistics.