The Science and Applications of Synthetic and Systems Biology
The Science and Applications of Synthetic and Systems Biology

Author: Institute of Medicine

Publisher: National Academies Press

Published: 2011-12-30

Total Pages: 570

ISBN-13: 0309219396

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Many potential applications of synthetic and systems biology are relevant to the challenges associated with the detection, surveillance, and responses to emerging and re-emerging infectious diseases. On March 14 and 15, 2011, the Institute of Medicine's (IOM's) Forum on Microbial Threats convened a public workshop in Washington, DC, to explore the current state of the science of synthetic biology, including its dependency on systems biology; discussed the different approaches that scientists are taking to engineer, or reengineer, biological systems; and discussed how the tools and approaches of synthetic and systems biology were being applied to mitigate the risks associated with emerging infectious diseases. The Science and Applications of Synthetic and Systems Biology is organized into sections as a topic-by-topic distillation of the presentations and discussions that took place at the workshop. Its purpose is to present information from relevant experience, to delineate a range of pivotal issues and their respective challenges, and to offer differing perspectives on the topic as discussed and described by the workshop participants. This report also includes a collection of individually authored papers and commentary.

Bacterial Biofilms
Bacterial Biofilms

Author: Tony Romeo

Publisher: Springer Science & Business Media

Published: 2008-02-26

Total Pages: 302

ISBN-13: 3540754180

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Throughout the biological world, bacteria thrive predominantly in surface-attached, matrix-enclosed, multicellular communities or biofilms, as opposed to isolated planktonic cells. This choice of lifestyle is not trivial, as it involves major shifts in the use of genetic information and cellular energy, and has profound consequences for bacterial physiology and survival. Growth within a biofilm can thwart immune function and antibiotic therapy and thereby complicate the treatment of infectious diseases, especially chronic and foreign device-associated infections. Modern studies of many important biofilms have advanced well beyond the descriptive stage, and have begun to provide molecular details of the structural, biochemical, and genetic processes that drive biofilm formation and its dispersion. There is much diversity in the details of biofilm development among various species, but there are also commonalities. In most species, environmental and nutritional conditions greatly influence biofilm development. Similar kinds of adhesive molecules often promote biofilm formation in diverse species. Signaling and regulatory processes that drive biofilm development are often conserved, especially among related bacteria. Knowledge of such processes holds great promise for efforts to control biofilm growth and combat biofilm-associated infections. This volume focuses on the biology of biofilms that affect human disease, although it is by no means comprehensive. It opens with chapters that provide the reader with current perspectives on biofilm development, physiology, environmental, and regulatory effects, the role of quorum sensing, and resistance/phenotypic persistence to antimicrobial agents during biofilm growth.

Focus on Bacterial Biofilms
Focus on Bacterial Biofilms

Author: Theerthankar Das

Publisher: BoD – Books on Demand

Published: 2022-11-02

Total Pages: 393

ISBN-13: 1803557958

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Bacterial biofilms are colonies of bacterial cells embedded in their self-produced matrix composed of polysaccharides, DNA, and proteins. They protect bacterial cells against antibiotics, antibacterial agents, soaps and detergents, and shear stress. Some of the most common biofilm-associated infections in humans include urinary tract infections, infection of wounds and surgical sites, diabetic foot ulcers, dental caries (tooth decay) and gingivitis (gum inflammation), ventilator-associated infections, sinusitis, microbial keratitis, secondary infection related to Covid-19 and other viral infections, and so on. Bacterial resistance to common antibiotics (e.g., penicillin, gentamycin, erythromycin, ciprofloxacin, etc.) is driving us to a catastrophic failure of our health systems. Strategies to develop novel antibacterial agents and technology must be prioritized to combat and eradicate biofilms and their associated challenges. This book provides a comprehensive overview of biofilms with chapters on bacterial virulence factors, quorum sensing in bacteria, antimicrobial resistance in bacteria, strategies to develop new antibacterial agents, and much more.

Microbial Biofilms
Microbial Biofilms

Author: Mahmoud Ghannoum

Publisher: John Wiley & Sons

Published: 2015-10-01

Total Pages: 636

ISBN-13: 1683673336

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An examination of the research and translational application to prevent and treat biofilm-associated diseases In the decade since the first edition of Microbial Biofilms was published, the interest in this field has expanded, spurring breakthrough research that has advanced the treatment of biofilm-associated diseases. This second edition takes the reader on an exciting, extensive review of bacterial and fungal biofilms, ranging from basic molecular interactions to innovative therapies, with particular emphasis on the division of labor in biofilms, new approaches to combat the threat of microbial biofilms, and how biofilms evade the host defense. Chapters written by established investigators cover recent findings, and contributions from investigators new to the field provide unique and fresh insights. Specifically, Microbial Biofilms provides state-of-the-art research in the field of bacterial and fungal biofilms detailed descriptions of the in vitro and in vivo models available to evaluate microbial biofilms future areas of research and their translational and clinical applications Microbial Biofilms is a useful reference for researchers and clinicians. It will also provide insight in the dynamic field of microbial biofilms for graduate and postgraduate students.

Biofilm Infections
Biofilm Infections

Author: Thomas Bjarnsholt

Publisher: Springer

Published: 2014-10-11

Total Pages: 0

ISBN-13: 9781489982285

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This book will cover both the evidence for biofilms in many chronic bacterial infections as well as the problems facing these infections such as diagnostics and treatment regimes. A still increasing interest and emphasis on the sessile bacterial lifestyle biofilms has been seen since it was realized that that less than 0.1% of the total microbial biomass lives in the planktonic mode of growth. The term was coined in 1978 by Costerton et al. who defined the term biofilm for the first time.In 1993 the American Society for Microbiology (ASM) recognised that the biofilmmode of growth was relevant to microbiology. Lately many articles have been published on the clinical implications of bacterial biofilms. Both original articles and reviews concerning the biofilm problem are available.

Microbial Biofilms
Microbial Biofilms

Author: Arindam Mitra

Publisher:

Published: 2020-02

Total Pages: 240

ISBN-13: 9781912530328

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Informative and up-to-date, this book is an invaluable and timely review on current research in biofilms and is an essential acquisition for anyone involved in this area.

Recent Trends in Biofilm Science and Technology
Recent Trends in Biofilm Science and Technology

Author: Manuel Simoes

Publisher: Academic Press

Published: 2020-06-04

Total Pages: 418

ISBN-13: 0128194987

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Recent Trends in Biofilm Science and Technology helps researchers working on fundamental aspects of biofilm formation and control conduct biofilm studies and interpret results. The book provides a remarkable amount of knowledge on the processes that regulate biofilm formation, the methods used, monitoring characterization and mathematical modeling, the problems/advantages caused by their presence in the food industry, environment and medical fields, and the current and emergent strategies for their control. Research on biofilms has progressed rapidly in the last decade due to the fact that biofilms have required the development of new analytical tools and new collaborations between biologists, engineers and mathematicians. - Presents an overview of the process of biofilm formation and its implications - Provides a clearer understanding of the role of biofilms in infections - Creates a foundation for further research on novel control strategies - Updates readers on the remarkable amount of knowledge on the processes that regulate biofilm formation

Bacterial Biofilms
Bacterial Biofilms

Author: Sadik Dincer

Publisher: BoD – Books on Demand

Published: 2020-10-07

Total Pages: 362

ISBN-13: 1789858992

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This book examines biofilms in nature. Organized into four parts, this book addresses biofilms in wastewater treatment, inhibition of biofilm formation, biofilms and infection, and ecology of biofilms. It is designed for clinicians, researchers, and industry professionals in the fields of microbiology, biotechnology, ecology, and medicine as well as graduate and postgraduate students.

Microbial Biofilms
Microbial Biofilms

Author: Dharumadurai Dhanasekaran

Publisher: BoD – Books on Demand

Published: 2016-07-13

Total Pages: 526

ISBN-13: 9535124358

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In the book Microbial Biofilms: Importance and applications, eminent scientists provide an up-to-date review of the present and future trends on biofilm-related research. This book is divided with four subdivisions as biofilm fundamentals, applications, health aspects, and their control. Moreover, this book also provides a comprehensive account on microbial interactions in biofilms, pyocyanin, and extracellular DNA in facilitating Pseudomonas aeruginosa biofilm formation, atomic force microscopic studies of biofilms, and biofilms in beverage industry. The book comprises a total of 21 chapters from valued contributions from world leading experts in Australia, Bulgaria, Canada, China, Serbia, Germany, Italy, Japan, the United Kingdom, the Kingdom of Saudi Arabia, Republic of Korea, Mexico, Poland, Portugal, and Turkey. This book may be used as a text or reference for everyone interested in biofilms and their applications. It is also highly recommended for environmental microbiologists, soil scientists, medical microbiologists, bioremediation experts, and microbiologists working in biocorrosion, biofouling, biodegradation, water microbiology, quorum sensing, and many other related areas. Scientists in academia, research laboratories, and industry will also find it of interest.

Biofilms in the Dairy Industry
Biofilms in the Dairy Industry

Author: Koon Hoong Teh

Publisher: John Wiley & Sons

Published: 2015-08-31

Total Pages: 292

ISBN-13: 1118876210

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In recent years, the formation and impacts of biofilms on dairy manufacturing have been studied extensively, from the effects of microbial enzymes produced during transportation of raw milk to the mechanisms of biofilm formation by thermophilic spore-forming bacteria. The dairy industry now has a better understanding of biofilms and of approaches that may be adopted to reduce the impacts that biofilms have on manufacturing efficiencies and the quality of dairy products. Biofilms in the Dairy Industry provides a comprehensive overview of biofilm-related issues facing the dairy sector. The book is a cornerstone for a better understanding of the current science and of ways to reduce the occurrence of biofilms associated with dairy manufacturing. The introductory section covers the definition and basic concepts of biofilm formation and development, and provides an overview of problems caused by the occurrence of biofilms along the dairy manufacturing chain. The second section of the book focuses on specific biofilm-related issues, including the quality of raw milk influenced by biofilms, biofilm formation by thermoduric streptococci and thermophilic spore-forming bacteria in dairy manufacturing plants, the presence of pathogens in biofilms, and biofilms associated with dairy waste effluent. The final section of the book looks at the application of modelling approaches to control biofilms. Potential solutions for reducing contamination throughout the dairy manufacturing chain are also presented. Essential to professionals in the global dairy sector, Biofilms in the Dairy Industry will be of great interest to anyone in the food and beverage, academic and government sectors. This text is specifically targeted at dairy professionals who aim to improve the quality and consistency of dairy products and improve the efficiency of dairy product manufacture through optimizing the use of dairy manufacturing plant and reducing operating costs.