The Epstein-Barr virus was discovered 15 years ago. Since that time an immense body of information has been accumu lated on this agent which has come to assume great signifi cance in many different fields of biological science. Thus, the virus has very special relevance in human medicine and oncology, in tumor virology, in immunology, and in mole cular virology, since it is the cause of infectious mononu cleosis and also the first human cancer virus, etiologically related to endemic Burkitt's lymphoma and probably to nasopharyngeal carcinoma. In addition, continuous human lymphoid cell lines initiated and maintained by the transform ing function of the virus genome provide a laboratory tool with wide and ever-growing applications. Innumerable papers on the Epstein-Barr virus have ap peared over recent years and reports of work with this agent now constitute a veritable flood. The present book provides the first and only comprehensive, authoritative over-view of all aspects of the virus by authors who have been the original and major contributors in their particular disciplines. A complete and up-to-date survey of this unique and important agent is thus provided which should be of great interest to experts, teachers, and students engaged in cancer research, virology, immunology, molecular biology, epide miology, and cell culture. Where topics have been dealt with from more than one of these viewpoints, some inevitable overlap and duplication has resulted; although this has been kept to a minimum, it has been retained in some places because of positive usefulness.
Epstein Barr virus (EBV) was discovered as the first human tumor virus around 50 years ago. Since its discovery in Burkitt’s lymphoma it has been associated with various other malignancies, infectious mononucleosis and even autoimmune diseases. The two book volumes on EBV summarize the first 50 years of research on this tumor virus, starting with historical perspectives on discovery, oncogenicity and immune control, reviewing the role that the virus plays in the various associated diseases and concluding with a discussion on how the immune system keeps persistent EBV infection under control in healthy EBV carriers and can be used to treat EBV associated diseases. The respective 32 chapters are written by international experts from three continents for health care providers, biomedical researchers and patients that are affected by EBV. The assembled knowledge should help to understand EBV associated diseases better and to develop EBV specific vaccination in the near future.
This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.
Rapid Virus Diagnosis: Application of Immunofluorescence presents developments in immunofluorescence as a technique for the diagnosis of virus infections. It discusses the effective and rapid methods for the diagnosis of virus infections. It addresses the application of fluorescent antibody techniques to the diagnosis and the investigation of virus infections and the assessment of their value both to the clinician and to the virologist. Some of the topics covered in the book are the fluorescence microscopy; nature of fluorescence; filter systems; transmitted light microscopy; interference filters for transmitted light microscopy; lamp centration and alignment of microscope; contrast-fluorescence condensers; photomicrography; and choice of microscope. The culture of viruses for production of antiserum is fully covered. The selection of cell lines or tissues for virus culture is discussed in detail. The text describes in depth the fluorescent antibody staining techniques. The preparation of specimens from respiratory infections is presented completely. A chapter is devoted to the respiratory syncytial virus. Another section focuses on the analysis influenza virus, paramyxoviruses, and picornaviruses. The book can provide useful information to doctors, virologists, students, and researchers.
This is the story of the discovery of the first human cancer virus. Through intriguing accounts that include some remarkable characters and individual stories from around the globe - including the UK, Africa, USA, and China - it tells the story of the Epstein-Barr virus and the understanding of its connections to a variety of other diseases.
Textbook of Medical Virology presents a critical review of general principles in the field of medical virology. It discusses the description and molecular structures of virus. It addresses the morphology and classifications of viruses. It also demonstrates the principal aspects of virus particle structure. Some of the topics covered in the book are the symmetrical arrangements of viruses; introduction to different families of animal viruses; biochemistry of virus particles; the immunological properties and biological activities of viral gene products; description of enzymatic activities of viruses; and haemagglutination, cell fusion, and haemolysis of viruses. The description and characteristics of viral antigens are covered. The identification and propagation of viruses in tissue and cell cultures are discussed. An in-depth analysis of the principles of virus replication is provided. A study of the morphogenesis of virions is also presented. A chapter is devoted to virus-induced changes of cell structures and functions. The book can provide useful information to virologists, microbiologists, students, and researchers.
Epstein Barr virus (EBV) was discovered as the first human tumor virus around 50 years ago. Since its discovery in Burkitt’s lymphoma it has been associated with various other malignancies, infectious mononucleosis and even autoimmune diseases. The two book volumes on EBV summarize the first 50 years of research on this tumor virus, starting with historical perspectives on discovery, oncogenicity and immune control, reviewing the role that the virus plays in the various associated diseases and concluding with a discussion on how the immune system keeps persistent EBV infection under control in healthy EBV carriers and can be used to treat EBV associated diseases. The respective 32 chapters are written by international experts from three continents for health care providers, biomedical researchers and patients that are affected by EBV. The assembled knowledge should help to understand EBV associated diseases better and to develop EBV specific vaccination in the near future.
From the Best Selling author Dr. Kasia Kines. Take your life back! For anyone suffering from Epstein-Barr Virus (EBV), chronic fatigue, autoimmune disorders, Infectious Mononucleosis, or other mystery illnesses, this is a must read!Do you feel lost and hopeless, living a life of illness with no answers? Do you feel unsupported by your medical team, left to suffer alone with no guidance? Are you searching for solutions to get your health and life back on track?Finally, a book that speaks to both the medical community and people inflicted by both mono and chronic conditions caused by EBV!The expanse of this pivotal book is far reaching - many people may not yet know they have been infected with EBV (commonly known as the "kissing disease"), but yet they struggle every day with chronic symptoms such as severe brain fog, debilitating fatigue, headaches, fever, chills, sore throat, body aches, and abdominal discomfort and can't seem to find a successful treatment solution.Eventually, some go on to develop autoimmune disorders, e.g. Lupus, Multiple Sclerosis, or Hashimoto's Thyroiditis and even cancer and are told that their immune system is simply confused and is now attacking itself, left with no solutions or hope for recovery.Alarmingly, chronic EBV infection is almost completely missed in medical practice, and as a result of never being tested, misinterpreting the test results, not being diagnosed, or being mis-diagnosed by their doctors, millions of people suffer debilitating conditions for many years with no answers.But this suffering can be avoided. And with this book, answers can be found.Author Dr. Kasia Kines is considered by her colleagues to be "one of the most brilliant, and importantly, clinically experienced functional nutritionists in the world." In Epstein-Barr Virus Solution, Dr. Kines provides a groundbreaking examination of EBV and not only how it causes chronic fatigue, autoimmune disorders, and even cancer but also how recovery is possible. This book was written in hopes that it will globally change the way EBV is understood, diagnosed, and treated.The deep journey into the existing research sheds light on the EBV virus for both the seasoned medical community and the layperson. Along with the validated research, Epstein-Barr Virus Solution presents practical, time-tested, and evidence-based clinical solutions for the testing and medical nutrition therapy for EBV, testing and lab interpretation, unique supplementation protocols, recovery strategies for stress, insomnia, fatigue, and toxicity, pantry and kitchen rehab for EBV, and delicious anti-EBV recipes. Through Dr. Kines' compassionate guidance, readers will feel confident to discuss their concerns with their doctor, to ask for testing, and to take their lives back from EBV. Epstein-Barr Virus Solution urges medical providers to hear their clients' concerns and provides the medical community with the research and insights needed to avoid misdiagnosis and common problems with testing for EBV.Epstein-Barr Virus Solution was made possible because of Dr. Kines' long-standing expertise as a functional clinical nutritionist who has dedicated her practice to working with clients inflicted by EBV. Dr. Kines tells readers in easy-to-understand language that recovery and hope for better health are possible through targeted nutrition and lifestyle changes. Readers are given a toolkit full of practical advice and guidance, including exclusive materials from Dr. Kines' life-changing 30-Day Detox Program that she has taught successfully for over 10 years.The research is out there, and Dr. Kasia Kines has found it, synthesized it, and utilized it to implement successful treatment protocols in her own clinic. Clients who had suffered years with chronic EBV infection symptoms are now recovering and living their lives.This book will provide those infected with EBV everything they need to finally take control of their health and take their life and happiness back.
Viral Immunology and Immunopathalogy covers topics concerning the role of cellular and humoral immunity in viral infections, factors responsible for the persistence and recurrence of viral infections in the presence of immunity, mechanisms of viral immunopathology, and concepts in the development of vaccines. The book describes the history of viral immunology; the synthesis and properties of viral antigens; and the humoral immune response to viruses. The text also discusses the mechanisms of viral neutralization; cellular immunity; the role of inflammatory cells and effector molecules in combating viral infections; and the genetic control of resistance. The book concludes with chapters on herd immunity; viral immunopathology; and viral immunology and immunopathology. Immunologists, pathologists, virologists, and microbiologists will find the book useful.
