Epigenetic Regulation and Non-histone Post-translational Modification in Cancer
Author: Yan Gong
Publisher: Frontiers Media SA
Published: 2023-05-03
Total Pages: 211
ISBN-13: 2832522262
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Epigenetic Mechanisms of Gene Regulation
Author: Vincenzo E. A. Russo
Publisher:
Published: 1996
Total Pages: 716
ISBN-13:
DOWNLOAD EBOOKMany inheritable changes in gene function are not explained by changes in the DNA sequence. Such epigenetic mechanisms are known to influence gene function in most complex organisms and include effects such as transposon function, chromosome imprinting, yeast mating type switching and telomeric silencing. In recent years, epigenetic effects have become a major focus of research activity. This monograph, edited by three well-known biologists from different specialties, is the first to review and synthesize what is known about these effects across all species, particularly from a molecular perspective, and will be of interest to everyone in the fields of molecular biology and genetics.
Epigenetics: Development and Disease
Author: Tapas Kumar Kundu
Publisher: Springer Science & Business Media
Published: 2012-11-13
Total Pages: 698
ISBN-13: 9400745257
DOWNLOAD EBOOKEpigenetics fine-tunes the life processes dictated by DNA sequences, but also kick-starts pathophysiological processes including diabetes, AIDS and cancer. This volume tracks the latest research on epigenetics, including work on new-generation therapeutics.
Epigenetics and Cancer, Part A
Author:
Publisher: Academic Press
Published: 2010-11-22
Total Pages: 411
ISBN-13: 0123808677
DOWNLOAD EBOOKGenes interact with the environment, experience, and biology of the brain to shape an animal’s behavior. This latest volume in Advances in Genetics, organized according to the most widely used model organisms, describes the latest genetic discoveries in relation to neural circuit development and activity. Explores the latest topics in neural circuits and behavior research in zebrafish, drosophila, C.elegans, and mouse models Includes methods for testing with ethical, legal, and social implications Critically analyzes future prospects
Epigenetic Mechanisms and Post-translational Modifications as Novel Therapeutic Targets in Cancer
Author: Yi-Chao Zheng
Publisher: Frontiers Media SA
Published: 2022-09-21
Total Pages: 159
ISBN-13: 2889769836
DOWNLOAD EBOOKThe Histone Code and Beyond
Author: Shelley L. Berger
Publisher: Springer
Published: 2014-11-27
Total Pages: 0
ISBN-13: 9783642421754
DOWNLOAD EBOOKMethylation of DNA at cytosine residues as well as post-translational modifications of histones, including phosphorylation, acetylation, methylation and ubiquitylation, contribute to the epigenetic information carried by chromatin. These changes play an important role in the regulation of gene expression by modulating the access of regulatory factors to the DNA. The use of a combination of biochemical, genetic and structural approaches has allowed demonstration of the role of chromatin structure in transcriptional control. The structure of nucleosomes has been elucidated and enzymes involved in DNA or histone modifications have been extensively characterized. Since deregulation of epigenetic marks has been reported in many cancers, a better understanding of the underlying molecular mechanisms bears the promise that new drug targets may soon be found. The newest developments in this quickly developing field are presented in this book.
Metabolism and Epigenetic Regulation: Implications in Cancer
Author: Tapas Kumar Kundu
Publisher: Springer Nature
Published: 2022-10-27
Total Pages: 622
ISBN-13: 3031076346
DOWNLOAD EBOOKMetabolic programs of individuals are key determinants for disease susceptibility and immune response. This book, edited by experts in the field, summarizes epigenetic signaling pathways that regulate metabolic programs associated with cancer and cancer-related secondary diseases. The first part of the book highlights key metabolic pathways that are implicated in cancer and provides a comprehensive overview on the carbohydrate, protein, lipid, amino- and nucleic acid metabolic pathways that are deregulated in cancer. Special attention is paid to the altered tumor micro-environment that is influenced by the metabolic milieu. Furthermore, the fundamental relationship between the cellular metabolic environment and cell death-mediated autophagy is discussed. The second part of the book covers our understanding of the fundamental epigenetic regulations that are implicated in controlling the metabolic programs in cancer cells. Many aspects of epigenetic regulation of non-coding RNAs as well as DNA/RNA methylation, which influencing metabolic homeostasis in cancer, are discussed in detail. Special emphasis is placed on the epigenetic regulation of the amino acid, glucose/carbohydrate metabolism and epigenetic regulation during hypoxia and its connection to cancer. Last but not least, the third part of the book covers small molecule modulators of histone modifying enzymes, which can be used as therapeutic tools. The readers learn about the cross-talk between epigenetics and immunometabolims, as well as the epigenetic regulation of oncometabolites to combat cancer. Given its scope, the book will appeal to a broad readership interested in epigenetic, cancer and metabolic research.
Introduction to Epigenetics
Author: Renato Paro
Publisher: Springer Nature
Published: 2021-03-23
Total Pages: 215
ISBN-13: 3030686701
DOWNLOAD EBOOKThis open access textbook leads the reader from basic concepts of chromatin structure and function and RNA mechanisms to the understanding of epigenetics, imprinting, regeneration and reprogramming. The textbook treats epigenetic phenomena in animals, as well as plants. Written by four internationally known experts and senior lecturers in this field, it provides a valuable tool for Master- and PhD- students who need to comprehend the principles of epigenetics, or wish to gain a deeper knowledge in this field. After reading this book, the student will: Have an understanding of the basic toolbox of epigenetic regulation Know how genetic and epigenetic information layers are interconnected Be able to explain complex epigenetic phenomena by understanding the structures and principles of the underlying molecular mechanisms Understand how misregulated epigenetic mechanisms can lead to disease
Epigenetic Regulation of Cancer - Part A
Author:
Publisher: Elsevier
Published: 2023-09-02
Total Pages: 272
ISBN-13: 0443221790
DOWNLOAD EBOOKIn Epigenetic Regulation of Cancer, a series of volumes from the International Review of Cell and Molecular Biology series, various experts in epigenetics critically cover multiple facets of cancer-associated epigenetic alterations, including the impact of epigenetic deregulation in all steps of oncogenesis as well as promising strategies to therapeutically target cancer-associated epigenetic deregulation. This collection aims at expanding our knowledge on this exciting field of investigation and providing fresh insights as a basis for further investigations that will hopefully translate into an improved clinical management of patients with cancer. The collection provides accurate and critical review articles from invited experts on the selected topic Each review provides the newest insights and remarks on multiple subjects of the topic The volume offers a broad range of perspectives on detailed features
Cancer Epigenetics
Author: Trygve Tollefsbol
Publisher: CRC Press
Published: 2008-09-19
Total Pages: 472
ISBN-13: 1420045806
DOWNLOAD EBOOKDuring the past few decades, it has become increasingly apparent that heredity is not the sole determining factor in disease development, such as cancer. This landmark work covers a wide array of aspects in the relatively new area of epigenetics, ranging from its role in the basic mechanisms of tumorigenesis, to the newest epigenetic drugs being de
