Fluorine and Health

Fluorine and Health

Author: Alain Tressaud

Publisher: Elsevier

Published: 2008-06-06

Total Pages: 821

ISBN-13: 0080558119

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Fluorine and Health presents a critical multidisciplinary overview on the contribution of fluorinated compounds to resolve the important global issue of medicinal monitoring and health care. The involved subjects are organized in three thematic parts devoted to Molecular Imaging, Biomedical Materials and Pharmaceuticals. Initially the key-position of partially fluorinated low molecular weight compounds labelled either with the natural 19F-isotope for Magnetic Resonance Imaging (MRI) or labelled with the radioactive [18F]-isotope for Positron Emission Tomography (PET) is highlighted. Both non-invasive methods belong to the most challenging in vivo imaging techniques in oncology, neurology and in cardiology for the diagnosis of diseases having the highest mortality in the industrialized countries. The manifold facets of fluorinated biomaterials range from inorganic ceramics to perfluorinated organic molecules. Liquid perfluorocarbons are suitable for oxygen transport and as potential respiratory gas carriers, while fluorinated polymers are connected to the pathology of blood vessels. Another important issue concerns the application of highly fluorinated liquids in ophthalmology. Moreover, fluorine is an essential trace element in bone mineral, dentine and tooth enamel and is applied for the prophylaxis and treatment of dental caries. The various origins of human exposure to fluoride species is detailed to promote a better understanding of the effect of fluoride species on living organisms.Medicinally relevant fluorinated molecules and their interactions with native proteins are the main focus of the third part. New molecules fluorinated in strategic position are crucial for the development of pharmaceuticals with desired action and optimal pharmacological profile. Among the hundreds of marketed active drug components there are more than 150 fluorinated compounds. The chapters will illustrate how the presence of fluorine atoms alters properties of bioactive compounds at various biochemical steps, and possibly facilitate its emergence as pharmaceuticals. Finally the synthetic potential of a fluorinase, the first C-F bond forming enzyme, is summarized. - New approach of topics involving chemistry, biology and medicinal techniques - Transdisciplinar papers on fluoride products - Importance of fluoride products in health - Updated data on specific topics


Eosinophils in Health and Disease

Eosinophils in Health and Disease

Author: James J. Lee

Publisher: Academic Press

Published: 2012-11-02

Total Pages: 679

ISBN-13: 012394385X

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Eosinophils in Health and Disease provides immunology researchers and students with a comprehensive overview of current thought and cutting-edge eosinophil research, providing chapters on basic science, disease-specific issues, therapeutics, models for study and areas of emerging importance.


Pediatric Allergy: Principles and Practice E-Book

Pediatric Allergy: Principles and Practice E-Book

Author: Donald Y. M. Leung

Publisher: Elsevier Health Sciences

Published: 2010-10-13

Total Pages: 705

ISBN-13: 1437737781

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Pediatric Allergy supplies the comprehensive guidance you need to diagnose, manage, and treat virtually any type of allergy seen in children. Drs. Leung, Sampson, Geha, and Szefler present the new full-color second edition, with coverage of the diagnosis and management of anaphylaxis, the immune mechanisms underlying allergic disease, the latest diagnostic tests, and more. Treat the full range of pediatric allergic and immunologic diseases through clinically focused coverage relevant to both allergists and pediatricians. Understand the care and treatment of pediatric patients thanks to clinical pearls discussing the best approaches. Easily refer to appendices that list common food allergies and autoantibodies in autoimmune diseases. Apply the newest diagnostic tests available—for asthma, upper respiratory allergy, and more—and know their benefits and contraindications. Treat the allergy at its source rather than the resulting reactions through an understanding of the immune mechanisms underlying allergic diseases. Get coverage of new research that affects methods of patient treatment and discusses potential reasons for increased allergies in some individuals. Better manage potential anaphylaxis cases through analysis of contributing facts and progression of allergic disease. Effectively control asthma and monitor its progression using the new step-by-step approach. Eliminate difficulty in prescribing antibiotics thanks to coverage of drug allergies and cross-reactivity.


Mast Cells and Basophils

Mast Cells and Basophils

Author: Gianni Marone

Publisher: Academic Press

Published: 2000-05-25

Total Pages: 738

ISBN-13: 0080535852

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Mast Cells and Basophils will be essential reading for immunologists, biochemists and medical researchers. Detailed chapters cover all aspects of mast cell and basophil research, from cell development, proteases, histamine, cysteinyl leukotrienes, physiology and pathology to the role of these cells in health and disease. Chapters also discuss the clinical implications of histamine receptor antagonists.


Human Eosinophils

Human Eosinophils

Author: Gianni Marone

Publisher: Karger Medical Scientific

Published: 2000

Total Pages: 0

ISBN-13: 9783805569743

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Eosinophils represent approximately 1% of peripheral blood leukocytes and play a central proinflammatory and immunoregulatory role in various immune disorders. This volume provides the reader with a comprehensive survey of the major aspects of human eosinophilic biology and immunology as well as the most clinically relevant aspects of eosinophil-related disorders. Expert contributions cover the ultrastructural and phenotypic characteristics of human eosinophils, and their fundamental biochemical features including receptors for IgE and chemokines. The production of cytokines and their role in the activation of eosinophils are reviewed. Furthermore, the classic eosinophil-related disorders such as hypereosinophilia, drug reactions, allergic disorders and some cardiovascular diseases are described. Each of the chapters is written by an investigator actively engaged in research on the topic under consideration. The well-edited and stimulating material compiled in this volume will be of interest to all those working in allergology, immunology, biochemistry and pulmonary medicine.


Severe Asthma

Severe Asthma

Author: Kian Fan Chung

Publisher: European Respiratory Society

Published: 2019-06-01

Total Pages: 365

ISBN-13: 1849841047

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Severe asthma is a form of asthma that responds poorly to currently available medication, and its patients represent those with greatest unmet needs. In the last 10 years, substantial progress has been made in terms of understanding some of the mechanisms that drive severe asthma; there have also been concomitant advances in the recognition of specific molecular phenotypes. This ERS Monograph covers all aspects of severe asthma – epidemiology, diagnosis, mechanisms, treatment and management – but has a particular focus on recent understanding of mechanistic heterogeneity based on an analytic approach using various ‘omics platforms applied to clinically well-defined asthma cohorts. How these advances have led to improved management targets is also emphasised. This book brings together the clinical and scientific expertise of those from around the world who are collaborating to solve the problem of severe asthma.


Indoor Allergens

Indoor Allergens

Author: National Research Council

Publisher: National Academies Press

Published: 1993-02-01

Total Pages: 321

ISBN-13: 0309048311

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More than 50 million Americans, one out of five, suffer from hay fever, asthma, and other allergic diseases. Many of these conditions are caused by exposure to allergens in indoor environments such as the house, work, and schoolâ€"where we spend as much as 98 percent of our time. Developed by medical, public health, and engineering professionals working together, this unique volume summarizes what is known about indoor allergens, how they affect human health, the magnitude of their effect on various populations, and how they can be controlled. The book addresses controversies, recommends research directions, and suggests how to assist and educate allergy patients, as well as professionals. Indoor Allergens presents a wealth of information about common indoor allergens and their varying effects, from significant hay fever to life-threatening asthma. The volume discusses sources of allergens, from fungi and dust mites to allergenic chemicals, plants, and animals, and examines practical measures for their control. Indoor Allergens discusses how the human airway and immune system respond to inhaled allergens and assesses patient testing methods, covering the importance of the patient's medical history and outlining procedures and approaches to interpretation for skin tests, in vitro diagnostic tests, and tests of patients' pulmonary function. This comprehensive and practical volume will be important to allergists and other health care providers; public health professionals; specialists in building design, construction, and maintenance; faculty and students in public health; and interested allergy patients.


Eosinophilic Gastrointestinal Diseases

Eosinophilic Gastrointestinal Diseases

Author: Glenn T. Furuta

Publisher: Clinics: Internal Medicine

Published: 2009

Total Pages: 0

ISBN-13: 9781437704891

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Drs. Glen Furuta and Dan Atkins have assembled an in-depth look at Eosinophilic Gastrointestinal Diseases as related to allergy with topics such as "Basic pathogenetic mechanisms of Eosinophilic Esophagitis", "Nutritional management of patients with food allergies and EGIDs", "Chemotactic factors role in EGIDs", "Biomarkers associated with allergic diseases", "Association of other allergic diseases with EGIDs" and much more!


Middleton's Allergy E-Book

Middleton's Allergy E-Book

Author: A Wesley Burks

Publisher: Elsevier Health Sciences

Published: 2019-09-25

Total Pages: 828

ISBN-13: 0323546986

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Through eight outstanding editions, Middleton's Allergy: Principles and Practice has been the reference of choice for both clinicians and researchers as both a practical reference and an effective self-assessment tool for board preparation. The 9th Edition continues the tradition of excellence with comprehensive coverage of all basic science and clinical applications regarding allergy practice and disease mechanisms. It brings you fully up to date with recent innovations in the diagnosis, prevention, and management of allergic disorders, including emerging global issues, the advent of precision medicine, and new immunologic therapies. - Offers unparalleled depth and up-to-date guidance on the full spectrum of allergy across the lifespan, with significant updates throughout. - Contains new chapters on Innate Lymphoid Cells, Systems Biology, and Treatment of Primary Immunodeficiency Diseases. - Discusses emerging topics such as epidemic thunderstorm asthma and precision medicine in allergic disorders. - Features more than 730 full-color illustrations, including many new cellular and molecular drawings of disease mechanisms. - Includes new Summary of Important Concepts boxes, plus new multiple-choice questions online with explanations and answers. - Features a new team of expert editors and more international contributors for a global perspective of this complex field. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.


Diagnostic Pathology: Thoracic E-Book

Diagnostic Pathology: Thoracic E-Book

Author: Saul Suster

Publisher: Elsevier Health Sciences

Published: 2017-01-24

Total Pages: 949

ISBN-13: 0323443052

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Part of the highly regarded Diagnostic Pathology series, this updated volume is a visually stunning, easy-to-use reference covering all aspects of thoracic pathology. Outstanding images make this an invaluable diagnostic aid for every practicing pathologist, resident, or fellow. This second edition incorporates the most recent clinical, pathological, histological, and molecular knowledge in the field to provide a comprehensive overview of all key issues relevant to today’s practice. Unsurpassed visual coverage, with carefully annotated gross pathology, histopathology, special stains, and correlative radiologic images that provide clinically and diagnostically important information. Designed to help you identify crucial elements of each diagnosis along with associated differential diagnoses and pitfalls to more quickly resolve problems during routine sign out of cases. Time-saving reference features include bulleted text, a variety of test data tables, key facts in each chapter, annotated images, and an extensive index. Thoroughly updated content throughout, reflecting new WHO classifications of adenocarcinoma of the lung and a proliferation of molecular markers. New coverage of targeted therapies in molecular testing that determine why, when, and where these precisely classified lung cancers are found and their biologic behavior.