Environmental Damage to DNA and the Protective Effects of Phytochemicals
Environmental Damage to DNA and the Protective Effects of Phytochemicals

Author: Bechan Sharma

Publisher: CRC Press

Published: 2021-08-02

Total Pages: 81

ISBN-13: 1000428583

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Environmental Damage to DNA and the Protective Effects of Phytochemicals provides information on the toxicity of natural as well as synthetic chemicals in the living systems. These can lead to DNA damage and the emergence of serious consequences or manifestations causing varied health hazards. In addition, the ten chapters of the book reflect on the possible applications of plants or plant extracts to impart protection for living cells from the xenobiotics-mediated DNA damage. The book offers comprehensive coverage of the many essential topics in the subject including: Environmental factors and DNA damage Molecular mechanisms associated with DNA damage by various environmental (Physical, Chemical and Biological) factors Synergistic effects of environmental factors Phytochemicals acting both as DNA protectants and genotoxicants Experimental models for the study of the genotoxic potential of environmental factors and protection by phytochemicals This book connects readers who possess a life sciences background to the current understanding, concept and mechanisms involved in environmental-factors-mediated DNA damage. Scientific terms are introduced, defined, described and placed appropriately in the text. The protective effect of some plant extracts/phytochemicals has also been included. Environmental Damage to DNA and the Protective Effects of Phytochemicals is intended to cater the need of BSc, MSc and research students who are striving to discover the mechanism(s) associated with protection of DNA by plant-based chemicals. This is the first edition of our book and the valuable suggestions and comments from the readers are solicited.

Modified Nucleic Acids in Biology and Medicine
Modified Nucleic Acids in Biology and Medicine

Author: Stefan Jurga

Publisher: Springer

Published: 2016-07-29

Total Pages: 456

ISBN-13: 3319341758

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This volume is comprised of 18 chapters, covering various aspects of DNA modification and RNA modified bases. It also discusses in detail circular RNA, therapeutic oligonucleotides and their different properties. The chemical nature of DNA, RNA, protein and lipids makes these macromolecules easily modifiable, but they are also susceptible to damage from both endogenous and exogenous agents. Alkylation and oxidation show a potential to disrupt the cellular redox equilibrium and cause cellular damage leading to inflammation and even chronic disease. Furthermore, DNA damage can drive mutagenesis and the resulting DNA sequence changes can induce carcinogenesis and cancer progression. Modified nucleosides can occur as a result of oxidative DNA damage and RNA turnover, and are used as markers for various diseases. To function properly some RNA needs to be chemically modified post-transcriptionally. Dysregulation of the RNA-modification pattern or of the levels of the enzymes that catalyze these modifications alters RNA functionality and can result in complex phenotypes, likely due to defects in protein translation. While modifications are best characterized in noncoding ribonucleic acids like tRNA and rRNA, coding mRNAs have also been found to contain modified nucleosides. This book is a valuable resource, not only for graduate students but also researchers in the fields of molecular medicine and molecular biology.

Plant-derived Bioactives
Plant-derived Bioactives

Author: Mallappa Kumara Swamy

Publisher: Springer Nature

Published: 2020-05-11

Total Pages: 619

ISBN-13: 9811517614

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Plants produce a vast number of bioactive compounds with different chemical scaffolds, which modulate a diverse range of molecular targets and are used as drugs for treating numerous diseases. Most present-day medicines are derived either from plant compounds or their derivatives, and plant compounds continue to offer limitless reserves for the discovery of new medicines. While different classes of plant compounds, like phenolics, flavonoids, saponins and alkaloids, and their potential pharmacological applications are currently being explored, their curative mechanisms are yet to be understood in detail. This book is divided into 2 volumes and offers detailed information on plant-derived bioactive compounds, including recent research findings. Volume 1, Plant-derived Bioactives: Chemistry and Mode of Action, discusses the chemistry of highly valued plant bioactive compounds and their mode of actions at the molecular level. Volume 2, Plant-derived Bioactives: Production, Properties and Therapeutic Applications, explores the sources, biosynthesis, production, biological properties and therapeutic applications of plant bioactives. Given their scope, these books are valuable resources for members of the scientific community wishing to further explore various medicinal plants and the therapeutic applications of their bioactive compounds. They appeal to scholars, teachers and scientists involved in plant product research, and facilitate the development of innovative new drugs.

Cruciferous Vegetables, Isothiocyanates and Indoles
Cruciferous Vegetables, Isothiocyanates and Indoles

Author: International Agency for Research on Cancer

Publisher: IARC

Published: 2004

Total Pages: 282

ISBN-13: 9789283230090

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This publication sets outs the findings of an IARC Working Group, held in Lyon, France in November 2003, which considered the benefits of a diet rich in cruciferous vegetables in helping to reduce the risk of various cancers. Cruciferous vegetables, such as broccoli, cabbage, cauliflower, watercress and brussel sprouts, contain substantial amounts of compounds which have been shown to inhibit the growth of cancers. This publication reviews current knowledge on the topic, including data from human, experimental and mechanistic studies, as well as making recommendations for future research and public health policy options.

Phytochemicals
Phytochemicals

Author: Toshiki Asao

Publisher: BoD – Books on Demand

Published: 2018-11-07

Total Pages: 220

ISBN-13: 1789843774

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Phytochemicals provides original research work and reviews on the sources of phytochemicals, and their roles in disease prevention, supplementation, and accumulation in fruits and vegetables. The roles of anthocyanin, flavonoids, carotenoids, and taxol are presented in separate chapters. Antioxidative and free radicle scavenging activity of phytochemicals is also discussed. The medicinal properties of Opuntia, soybean, sea buckthorn, and gooseberry are presented in a number of chapters. Supplementation of plant extract with phytochemical properties in broiler meals is discussed in one chapter. The final two chapters include the impact of agricultural practices and novel processing technologies on the accumulation of phytochemicals in fruits and vegetables. This book mainly focuses on medicinal plants and the disease-preventing properties of phytochemicals, which will be a useful resource to the reader.

Plant-Based Functional Foods and Phytochemicals
Plant-Based Functional Foods and Phytochemicals

Author: Megh R. Goyal

Publisher: CRC Press

Published: 2021-03-30

Total Pages: 348

ISBN-13: 100009023X

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Plant-Based Functional Foods and Phytochemicals: From Traditional Knowledge to Present Innovation covers the importance of the therapeutic health benefits of phytochemicals derived from plants. It discusses the isolation of potential bioactive molecules from plant sources along with their value to human health. It focuses on physical characteristics, uniqueness, uses, distribution, traditional and nutritional importance, bioactivities, and future trends of different plant-based foods and food products. Functional foods, beyond providing basic nutrition, may offer a potentially positive effect on health and cures for various disease conditions, such as metabolic disorders (including diabetes), cancer, and chronic inflammatory reactions. The volume looks at these natural products and their bioactive compounds that are increasingly utilized in preventive and therapeutic medications and in the production of pharmaceutical supplements and as food additives to increase functionality. It also describes the concept of extraction of bioactive molecules from plant sources, both conventional and modern extraction techniques, available sources, biochemistry, structural composition, and potential biological activities.

An Evidence-based Approach to Phytochemicals and Other Dietary Factors
An Evidence-based Approach to Phytochemicals and Other Dietary Factors

Author: Jane Higdon

Publisher: Thieme

Published: 2012-11-07

Total Pages: 588

ISBN-13: 3132579963

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Now in a completely updated second edition, An Evidence-based Approach to Dietary Phytochemicals and Other Dietary Factors is a trusted resource for all health professionals who need to interpret the explosion of information on the role of a plant-based diet in health and disease. It consolidates a wealth of scientifically accurate, peer-reviewed data on plant foods, dietary phytochemicals, and dietary supplements, and includes information on essential intake recommendations, dietary sources, nutrient and drug interactions, phytochemicals in disease prevention, possible adverse effects, and much more. Special features: All chapters revised and updated, with new sections on choline, coenzyme Q10, L-Carnitine, lipoic acid, and other dietary factors Logically structured for quick access to information: begins with the evidence-based benefits of fruits and vegetables, legumes, nuts, whole grains, coffee, and tea; and goes on to the scientific and clinical data on individual dietary phytochemicals and classes of phytochemicals, including carotenoids, flavonoids, fiber, and more Summaries at the end of each chapter for rapid review Peer-reviewed by experts in the field, ensuring that all material is accurate and up-to-date The well-constructed appendix includes not only a quick reference to diseases and foods and where to find them in the book, but also useful tables on phytochemical-drug interactions, phytochemical-nutrient interactions, and phytochemical-rich foods; a summary of the glycemic index of dietary carbohydrates; and a comprehensive glossary of terms

Dietary Phytochemicals
Dietary Phytochemicals

Author: Chukwuebuka Egbuna

Publisher: Springer Nature

Published: 2021-08-20

Total Pages: 262

ISBN-13: 3030729990

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This book presents comprehensive coverage on the importance of good nutrition in the treatment and management of obesity, cancer and diabetes. Naturally occurring bioactive compounds are ubiquitous in most dietary plants available to humans and provide opportunities for the management of diseases. The text provides information about the major causes of these diseases and their association with nutrition. The text also covers the role of dietary phytochemicals in drug development and their pathways. Later chapters emphasize novel bioactive compounds as anti-diabetic, anti-cancer and anti-obesity agents and describe their mechanisms to regulate cell metabolism. Written by global team of experts, Dietary Phytochemicals: A Source of Novel Bioactive Compounds for the Treatment of Obesity, Cancer and Diabetes describes the potentials of novel phytochemicals, their sources, and underlying mechanism of action. The chapters were drawn systematically and incorporated sequentially to facilitate proper understanding. This book is intended for nutritionists, physicians, medicinal chemists, drug developers in research and development, postgraduate students and scientists in area of nutrition and life sciences.

Handbook of Oxidative Stress in Cancer: Therapeutic Aspects
Handbook of Oxidative Stress in Cancer: Therapeutic Aspects

Author: Sajal Chakraborti

Publisher: Springer Nature

Published: 2022-09-28

Total Pages: 4078

ISBN-13: 9811654220

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This reference book, which is the second volume of Targeting Oxidative Stress in Cancer, explores oxidative stress as the potential therapeutic target for cancer therapy. The initial chapters discuss the molecular mechanisms of oxidative stress and its effects on different signaling pathways. Subsequently, the sections examine the impact of redox signaling on tumor cell proliferation and consider the therapeutic potential of dietary phytochemicals and nutraceuticals in reactive oxygen species (ROS)-induced cancer. In turn, it examines the evidence supporting the use of Vitamin C in cancer management, before presenting various synthetic and natural compounds that have therapeutic implications for oxidative stress-induced cancer. It also explores the correlation between non-coding RNA and oxidative stress. Furthermore, the book summarizes the role of stem cells in ROS-induced cancer therapy and reviews the therapeutic applications of nanoparticles to alter redox haemostasis in cancer cells. Lastly, it explores heat-shock proteins, ubiquitin ligases, and probiotics as potential therapeutic agents in ROS-mediated cancer. This book is a useful resource for basic and translational scientists as well as clinicians interested in the field of oxidative stress and cancer therapy. ​

Environmental Biotechnology Volume 4
Environmental Biotechnology Volume 4

Author: K. M. Gothandam

Publisher: Springer Nature

Published: 2021-09-24

Total Pages: 269

ISBN-13: 3030777952

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This book reviews the production of bioplastic from various raw materials and recycling wastewater into useful bioproducts by bacteria. In addition, it also addresses the recent advancement in pest control in rice plants, different methods to analyse genotoxicity on soil samples and the effect of phytocompounds on acrylamide-induced toxicity in Drosophilla. Interestingly, this book also discusses mesoporous silica nanoparticles' role as nanocarrier material for inhibiting the cancer cell, especially breast cancer and various biotechnological applications of marine fungal exopolysaccharides.