Sex and Gender Differences in Infection and Treatments for Infectious Diseases
Sex and Gender Differences in Infection and Treatments for Infectious Diseases

Author: Sabra L. Klein

Publisher: Springer Nature

Published: 2023-09-11

Total Pages: 282

ISBN-13: 3031351398

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This fully revised and significantly expanded second edition examines sex and gender differences in the immune system's response to bacterial, viral, and parasitic infections. The volume discusses both common and distinct molecular mechanisms that mediate these differences and illustrates how responses to vaccines may differ between the sexes and in pregnant individuals. Special emphasis is placed on the interplay between hormones and the immune system in the pathogenesis of HIV, SARS-CoV-2, influenza, malaria, tuberculosis, and amebiasis. This second edition includes completely rewritten chapters as well as all new contents. This book is intended for researchers in academia and industry as well as clinicians in the fields of microbiology, immunology, and pharmacology. By expanding knowledge in sex and gender medicine as a basis for developing personalized treatment strategies, the book contributes to UN Sustainable Development Goals 3 (health and well-being) and 5 (gender equality).

Handbook on Immunosenescence
Handbook on Immunosenescence

Author: Tamas Fulop

Publisher: Springer Science & Business Media

Published: 2009-02-27

Total Pages: 1693

ISBN-13: 1402090633

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This authoritative handbook covers all aspects of immunosenescence, with contributions from experts in the research and clinical areas. It examines methods and models for studying immunosenescence; genetics; mechanisms including receptors and signal transduction; clinical relevance in disease states including infections, autoimmunity, cancer, metabolic syndrome, neurodegenerative diseases, frailty and osteoporosis; and much more.

Oncology Rehabilitation E-Book
Oncology Rehabilitation E-Book

Author: Deborah Doherty

Publisher: Elsevier Health Sciences

Published: 2022-07-23

Total Pages: 884

ISBN-13: 0323810888

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- Coverage of physical therapy patient management includes acute care, outpatient, and multidisciplinary clinical settings, along with in-depth therapeutic management interventions. - Content on the continuum of cancer care addresses the primordial, primary, secondary, tertiary, and quaternary stages in prevention and treatment. - Focus on clinicians includes the professional roles, responsibilities, self-care, and values of the oncology rehabilitation clinician as an integral member of the cancer care team. - Information on inseparable contextual factors helps in dealing with administrative infrastructure and support, advocacy, payment, and reimbursement of rehabilitation as well as public policy. - Evidence Summary and Key Points boxes highlight important information for quick, at-a-glance reference. - Clinical case studies and review questions enhance your critical thinking skills and help you prepare for board certification, specialty practice, and/or residency. - Enhanced eBook version— included with print purchase— allows you to access all of the text, figures, and references from the book on a variety of devices. - Resources in the eBook include videos, board-review questions, case studies, and a curriculum map to highlight and demonstrate the correlation to the requirements for Oncology Rehabilitation Residency programs and the board certification exam. - Guidebook approach provides immediate, meaningful application for the practicing oncology rehabilitation clinician.

Non-Reproductive Actions of Sex Steroids
Non-Reproductive Actions of Sex Steroids

Author: Gregory R. Bock

Publisher: John Wiley & Sons

Published: 2008-04-30

Total Pages: 284

ISBN-13: 0470514760

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Prominent clinicians and researchers from diverse disciplines discuss the basic cell and molecular biology of steroid action and sex steroids' effects on the nervous and immune systems. Provides an integrated evaluation of the advantages and disadvantages of hormone replacement therapy.

Testosterone and Aging
Testosterone and Aging

Author: Institute of Medicine

Publisher: National Academies Press

Published: 2004-03-12

Total Pages: 239

ISBN-13: 0309090636

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Popular culture often equates testosterone with virility, strength, and the macho male physique. Viewed by some as an "antiaging tonic," testosterone's reputation and increased use by men of all ages in the United States have outpaced the scientific evidence about its potential benefits and risks. In particular there has been growing concern about an increase in the number of middle-aged and older men using testosterone and the lack of scientific data on the effect it may have on aging males. Studies of testosterone replacement therapy in older men have generally been of short duration, involving small numbers of participants and often lacking adequate controls. Testosterone and Aging weighs the options of future research directions, examines the risks and benefits of testosterone replacement therapy, assesses the potential public health impact of such therapy in the United States, and considers ethical issues related to the conduct of clinical trials. Testosterone therapy remains an attractive option to many men even as speculation abounds regarding its potential.

Exploring the Biological Contributions to Human Health
Exploring the Biological Contributions to Human Health

Author: Institute of Medicine

Publisher: National Academies Press

Published: 2001-07-02

Total Pages: 287

ISBN-13: 0309132975

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It's obvious why only men develop prostate cancer and why only women get ovarian cancer. But it is not obvious why women are more likely to recover language ability after a stroke than men or why women are more apt to develop autoimmune diseases such as lupus. Sex differences in health throughout the lifespan have been documented. Exploring the Biological Contributions to Human Health begins to snap the pieces of the puzzle into place so that this knowledge can be used to improve health for both sexes. From behavior and cognition to metabolism and response to chemicals and infectious organisms, this book explores the health impact of sex (being male or female, according to reproductive organs and chromosomes) and gender (one's sense of self as male or female in society). Exploring the Biological Contributions to Human Health discusses basic biochemical differences in the cells of males and females and health variability between the sexes from conception throughout life. The book identifies key research needs and opportunities and addresses barriers to research. Exploring the Biological Contributions to Human Health will be important to health policy makers, basic, applied, and clinical researchers, educators, providers, and journalists-while being very accessible to interested lay readers.

Sex Hormones and Immunity to Infection
Sex Hormones and Immunity to Infection

Author: Sabra L. Klein

Publisher: Springer Science & Business Media

Published: 2009-10-22

Total Pages: 323

ISBN-13: 3642021557

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Why sex matters Among human and nonhuman animals, the prevalence and intensity of infection typically is higher in males than females and may reflect differences in exposure as well as susceptibility to pathogens. Elevated immunity among females is a double-edged sword in which it is beneficial against infectious diseases but is detrimental in terms of increased development of autoimmune diseases. The present book critically reviews the evolutionary origin and the functional mechanisms responsible for sexual dimorphism in response to infection. It emphasizes the value of examining responses in both males and females to improve our understanding about host-pathogen interactions in both sexes. The contributors are experts in their specific disciplines which range from microbiology and immunology to genetics, pathology, and evolutionary biology. The book aims at bringing insight to the treatment and management of infectious diseases; it delineates areas where knowledge is lacking and highlights future avenues of research.