Pharmacokinetics of Drugs

Pharmacokinetics of Drugs

Author: Peter G. Welling

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 546

ISBN-13: 3642786804

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A compilation of researchers' experience in the areas of bioanalysis, pharmacokinetics, and drug metabolism, to present an up-to-date and comprehensive treatise on the application of these and related technologies in drug discovery, development, and clinical use. Contents cover descriptions of analytical methods, in vitro metabolism technology and membrane transport, reappraisal of classical pharmacokinetic problems, and the time course of drug action. The book concludes with a description of PET and imaging methods in pharmacokinetics and an appendix containing a critical appraisal of computer methods and pharmacokinetic software available for PCs.


Church of Spies

Church of Spies

Author: Mark Riebling

Publisher: Basic Books

Published: 2015-09-29

Total Pages: 385

ISBN-13: 0465061559

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The heart-pounding history of how Pope Pius XII -- often labeled "Hitler's Pope" -- was in fact an anti-Nazi spymaster, plotting against the Third Reich during World War II. The Vatican's silence in the face of Nazi atrocities remains one of the great controversies of our time. History has accused wartime pontiff Pius the Twelfth of complicity in the Holocaust and dubbed him "Hitler's Pope." But a key part of the story has remained untold. Pope Pius in fact ran the world's largest church, smallest state, and oldest spy service. Saintly but secretive, he sent birthday cards to Hitler -- while secretly plotting to kill him. He skimmed from church charities to pay covert couriers, and surreptitiously tape-recorded his meetings with top Nazis. Under his leadership the Vatican spy ring actively plotted against the Third Reich. Told with heart-pounding suspense and drawing on secret transcripts and unsealed files by an acclaimed author, Church of Spies throws open the Vatican's doors to reveal some of the most astonishing events in the history of the papacy. Riebling reveals here how the world's greatest moral institution met the greatest moral crisis in history.


Gut Feeling and Digestive Health in Nineteenth-Century Literature, History and Culture

Gut Feeling and Digestive Health in Nineteenth-Century Literature, History and Culture

Author: Manon Mathias

Publisher: Springer

Published: 2018-11-17

Total Pages: 283

ISBN-13: 3030018571

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This book considers the historical and cultural origins of the gut-brain relationship now evidenced in numerous scientific research fields. Bringing together eleven scholars with wide interdisciplinary expertise, the volume examines literal and metaphorical digestion in different spheres of nineteenth-century life. Digestive health is examined in three sections in relation to science, politics and literature during the period, focusing on Northern America, Europe and Australia. Using diverse methodologies, the essays demonstrate that the long nineteenth century was an important moment in the Western understanding and perception of the gastroenterological system and its relation to the mind in the sense of cognition, mental wellbeing, and the emotions. This collection explores how medical breakthroughs are often historically preceded by intuitive models imagined throughout a range of cultural productions.