Ecstasy: The Clinical, Pharmacological and Neurotoxicological Effects of the Drug MDMA

Ecstasy: The Clinical, Pharmacological and Neurotoxicological Effects of the Drug MDMA

Author: Stephen J. Peroutka

Publisher: Springer Science & Business Media

Published: 1989-12-31

Total Pages: 270

ISBN-13: 9780792303053

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The variety of viewpoints expressed in this book illustrate the many contro versies surrounding MDMA [1]. On the one hand, the proponents ofMDMA use believe this agent offers a unique psychoactive effect that may have important clinical applications, especially in the field of psychotherapy. On the other hand, the scientific data concerning the neurotoxic effects of the drug are unequivocal. The most striking feature of the human information of MDMA is the paucity of data that has been generated on the drug since it was patented in 1914. As pointed out by Beck (Chapter 6) and others, a clear need exists for better epidemiological and clinical data on MDMA. In the absence of such data, arguments both for and against the cotinued use ofMDMA with humans will be difficult to support. Unfortunately, the currently available data must be used to develop rational policies for potential human users of MDMA. At the present time, there are no data indicating that recreational doses of MDMA permanently damage the human brain. Nonetheless, based on a review of the contents of this book as well as on informal discussions with approximately 200 recreational users of MDMA, the following personal observations suggest that MDMA is radically different from other recreational drugs.


Ecstasy: The Clinical, Pharmacological and Neurotoxicological Effects of the Drug MDMA

Ecstasy: The Clinical, Pharmacological and Neurotoxicological Effects of the Drug MDMA

Author: Stephen J. Peroutka

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 252

ISBN-13: 1461314852

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The variety of viewpoints expressed in this book illustrate the many contro versies surrounding MDMA [1]. On the one hand, the proponents ofMDMA use believe this agent offers a unique psychoactive effect that may have important clinical applications, especially in the field of psychotherapy. On the other hand, the scientific data concerning the neurotoxic effects of the drug are unequivocal. The most striking feature of the human information of MDMA is the paucity of data that has been generated on the drug since it was patented in 1914. As pointed out by Beck (Chapter 6) and others, a clear need exists for better epidemiological and clinical data on MDMA. In the absence of such data, arguments both for and against the cotinued use ofMDMA with humans will be difficult to support. Unfortunately, the currently available data must be used to develop rational policies for potential human users of MDMA. At the present time, there are no data indicating that recreational doses of MDMA permanently damage the human brain. Nonetheless, based on a review of the contents of this book as well as on informal discussions with approximately 200 recreational users of MDMA, the following personal observations suggest that MDMA is radically different from other recreational drugs.


Pharmacology and Abuse of Cocaine, Amphetamines, Ecstasy and Related Designer Drugs

Pharmacology and Abuse of Cocaine, Amphetamines, Ecstasy and Related Designer Drugs

Author: Enno Freye

Publisher: Springer Science & Business Media

Published: 2009-09-21

Total Pages: 286

ISBN-13: 9048124484

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Finally - a book that covers all aspects of the illicit use of cocaine, amphetamines, ecstasy and/or designer drugs such as GHB, written by two experts in their field. The use of these drugs remains a continuous threat in health and medical care delivery, and this book will be an essential asset to the physician who may have to face the evaluation of patients whose use of these drugs compromises an effective treatment plan for other health issues. The book has been conceived to fill the void in existing physician reference materials, and provides a comprehensive review of the theoretical knowledge and scope of pharmacotherapy in individuals who are hooked on a psychoactive substance. While detailed scientific information is obtainable in other major articles, the book's straightforward format and style, along with its illustrations, will make for easy reading as emphasis is put on information specifically related to drugs that occur most abused in today’s society. The information provided is based on clinical practice rather than pure experimental data, which will give the physician more effective tools useful in their daily practice. Many mechanisms of action of abuse are described in detail and references are provided to direct the reader to further sources for additional information. As a special feature, the book incorporates uncluttered tables and charts, which result in immediate clarification of the mode of action on the central nervous system and the reason for misuse, thus avoiding usual long and fatiguing text in common reference books. The book aims to give the reader a clear and concise plan on what to do when being faced with an overdose situation. A well-organized Table of Contents rapidly leads the reader from general pharmacological issues to the specific overdose syndrome and its management. Additionally, significant emphasis is placed on the practical do's and don’ts for physicians, with special reference to the predictive signs of aberrant drug-related behavior and the identification of the drug diverter by using urine drug screening.


Ecstasy: The Complete Guide

Ecstasy: The Complete Guide

Author: Julie Holland

Publisher: Inner Traditions / Bear & Co

Published: 2001-08

Total Pages: 470

ISBN-13: 9780892818570

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Written by the world's leading experts on MDMA, "Ecstasy: The Complete Guide" takes the first unbiased look at the risks and the benefits of this unique drug, including the science of how it works; its promise as a treatment for depression, post-traumatic stress disorders, and other mental illnesses; and how to minimize the risks of use.


Ketamine

Ketamine

Author: David T. Yew

Publisher: CRC Press

Published: 2015-03-16

Total Pages: 406

ISBN-13: 1466583401

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Increasing use of ketamine as a recreational drug in Asia, Europe, and America is a great burden on society at large, leading to aspirational strain, unemployment, and crime. These societal effects have led to growing interest among researchers and clinicians in ketamine's effects on various systems of the body. Ketamine: Use and Abuse reviews the


Medical Toxicology of Drug Abuse

Medical Toxicology of Drug Abuse

Author: Donald G. Barceloux

Publisher: John Wiley & Sons

Published: 2012-02-03

Total Pages: 1080

ISBN-13: 1118106059

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This book provides a broad reference covering important drugs of abuse including amphetamines, opiates, and steroids. It also covers psychoactive plants such as caffeine, peyote, and psilocybin. It provides chemical structures, analytical methods, clinical features, and treatments of these drugs of abuse, serving as a highly useful, in-depth supplement to a general medical toxicology book. The style allows for the easy application of the contents to searchable databases and other electronic products, making this an essential resource for practitioners in medical toxicology, industrial hygiene, occupational medicine, pharmaceuticals, environmental organizations, pathology, and related fields.


Pursuit of Ecstasy

Pursuit of Ecstasy

Author: Jerome Beck

Publisher: SUNY Press

Published: 1994-03-08

Total Pages: 256

ISBN-13: 9780791418185

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The authors have produced the first “on the ground” study (not just clinical or chemical) of MDMA (3, 4-methylenedioxymethamphetamine), or “ecstasy” as it is frequently designated. A psychoactive substance related to both the amphetamines and mescaline, MDMA has become popular in recent years as one of the new “designer” drugs. First used in therapeutic treatment, its recreational or street use has increased in recent years. The authors track the efforts (with psychiatrists and researchers in opposition) of the DEA to ban the drug.


The Psychopharmacology of Hallucinogens

The Psychopharmacology of Hallucinogens

Author: Richard C. Stillman

Publisher: Elsevier

Published: 2013-10-22

Total Pages: 349

ISBN-13: 1483146065

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The Psychopharmacology of Hallucinogens focuses on the properties, compositions, functions, transformations, and reactions of hallucinogens. The selection first offers information on the biosynthesis and action of hallucinogens in mammals; role of biogenic amines in the actions of monomethoxy-amphetamines; and molecular mechanism of action of hallucinogens. The book then takes a look at the molecular determinants for interaction with the LSD receptor, including biological studies, molecular reactivity, and summation of the molecular polarization complexes. The text examines the progress on the development of a receptor model for hallucinogenic amphetamines; characterization of psychotomimetics; physical identification of hallucinogenic compounds; and aspects of the pharmacology of phencyclidine. The book also underscores the effects of LSD, mescaline, and DMT, including effects on humans, proposed model, and effects of monoamine manipulations. The text also presents analysis of hallucinogens by Pavlovian conditioning, behavioral measures of hallucinogenic behavior, and drug model of hallucinosis. The selection is a dependable reference for readers interested in the study of hallucinogens.


Drug and Alcohol Abuse

Drug and Alcohol Abuse

Author: Marc A. Schuckit

Publisher: Springer Science & Business Media

Published: 2013-03-09

Total Pages: 418

ISBN-13: 1475732325

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Written to serve the needs of clinicians handling emergency problems, and the student seeking an introduction to abused substances, the new fifth edition of this acclaimed text offers the most up-to-date clinically oriented guide available in the field of drug and alcohol abuse. This valuable work continues to set the standard for substance abuse research.