This book presents the latest advances in flowsheet simulation of solids processes, focusing on the dynamic behaviour of systems with interconnected solids processing units, but also covering stationary simulation. The book includes the modelling of solids processing units, for example for comminution, sifting and particle formulation and also for reaction systems. Furthermore, it examines new approaches for the description of solids and their property distributions and for the mathematical treatment of flowsheets with multivariate population balances.
The book presents a series of articles devoted to modeling, simulation, and optimization of processes, mainly chemical. General methods for process modeling and numerical simulation are described with flowsheeting. Population balances are addressed in detail with application to crystal production; energy saving is frequently optimized, including exergy analysis. The coupling between process simulation and computational fluid dynamics is studied for air classification and bubble columns. Pressure swing adsorption, reactive distillation, and nanofiltration are explained in general and applied to particular processes. The synthesis of carbon dots is solved by the design of experiments method. A safety study addresses the consequences of gas explosion.
In this Ph.D. thesis a system of coupled fluidized bed reactors is modelled and simulated dynamically. Chemical Looping Combustion was used as an exemplary process in both the numerical and the experimental part of this work. For the simulation purpose a novel flowsheeting software was used and models for the needed process units developed and integrated into this software. The needed unit models were three interconnected fluidized bed reactors in circulating and bubbling operation conditions, a cyclone for gas-solid separation and loop seals, which ensured solids transport and gas separation between the reactors. Additionally, lab scale experiments on the reactivity of the used solids, oxygen carrier and solid fuels, were conducted and kinetic parameters extracted. All unit models were connected to a process flowsheet and simulated dynamically. The simulation results were compared to experimental data from a 25 kWth pilot plant operated at the university by the author. It could be shown that a detailed and dynamic simulation of the whole process can be carried out over a time period of more than 45 minutes and the experimental results from start-up, steady state operation and shutdown of the plant were predicted accurately.
The European Symposium on Computer Aided Process Engineering (ESCAPE) series presents the latest innovations and achievements of leading professionals from the industrial and academic communities. The ESCAPE series serves as a forum for engineers, scientists, researchers, managers and students to present and discuss progress being made in the area of computer aided process engineering (CAPE). European industries large and small are bringing innovations into our lives, whether in the form of new technologies to address environmental problems, new products to make our homes more comfortable and energy efficient or new therapies to improve the health and well being of European citizens. Moreover, the European Industry needs to undertake research and technological initiatives in response to humanity's "Grand Challenges," described in the declaration of Lund, namely, Global Warming, Tightening Supplies of Energy, Water and Food, Ageing Societies, Public Health, Pandemics and Security. Thus, the Technical Theme of ESCAPE 21 will be "Process Systems Approaches for Addressing Grand Challenges in Energy, Environment, Health, Bioprocessing & Nanotechnologies."
Inspired by the leading authority in the field, the Centre for Process Systems Engineering at Imperial College London, this book includes theoretical developments, algorithms, methodologies and tools in process systems engineering and applications from the chemical, energy, molecular, biomedical and other areas. It spans a whole range of length scales seen in manufacturing industries, from molecular and nanoscale phenomena to enterprise-wide optimization and control. As such, this will appeal to a broad readership, since the topic applies not only to all technical processes but also due to the interdisciplinary expertise required to solve the challenge. The ultimate reference work for years to come.
Fluidized bed dryers are the prime choice when it comes to drying of heat sensitive products, commonly processed in the pharmaceutical and food industry. As many products in these industries are fine and cohesive, mechanical vibration of the dryer is used to enable or improve fluidization. Thus, the goal of this thesis is the development of a fluidized bed drying model that accounts for the influence of mechanical vibration of the dryer, as well as its implementation in an open-source flowsheet simulation framework. Continuously operated fluidized bed dryers under steady-state conditions are the focus of this thesis. The aim during model development and implementation is the broadest possible application range of the model. A custom-built vibrated fluidized bed dryer is designed and constructed for comprehensive investigations of fluidized bed hydrodynamics and drying kinetics. Based on experimental investigations, a semi-empirical model for hydrodynamics of fine and cohesive powders is developed. The new model is combined with established models to allow for the flowsheet simulation of fluidized bed dryers for particles of all Geldart groups. Additionally, the influence of vibration is accounted for. Comprehensive validation experiments are performed for particles of different Geldart groups, different dryer geometries and a variety of process parameters, including mechanical vibration. Comparison of model predictions with experimental data attributes high accuracy of predicted particle and gas properties. Furthermore, sensitivity analyses are conducted to identify potential weaknesses in underlying model assumptions. Hereby, the validity of underlying assumptions is confirmed and potential optimization parameters for different applications are identified. The proposed model is unprecedented in terms of range of process parameters, variety of particle properties and dryer geometries, tested and found valid for.
The book bridges the gap between pharmaceutics and molecular modelling at the micro, meso and macro scale. It covers Lipinski's rule of five, nanoparticulate drug delivery, computational prediction of drug solubility and ability to cross blood brain barrier, computer-based simulation of pharmacokinetic parameters, virtual screening of mucoadhesive polymers, QSPR modelling, designing of 2D nanomaterials and role of principal component analysis.
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Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. This self-learning guide shows how to start using Aspen Plus to solve chemical engineering problems quickly and easily Discover how to solve challenging chemical engineering problems with Aspen Plus—in just 24 hours, and with no prior experience. Developed at McMaster University over a seven-year period, the book features visual guides to using detailed mathematical models for a wide range of chemical process equipment, including heat exchangers, pumps, compressors, turbines, distillation columns, absorbers, strippers, and chemical reactors. Learn Aspen Plus in 24 Hours shows, step-by-step, how to configure and use Aspen Plus v9.0 and apply its powerful features to the design, operation, and optimization of safe, profitable manufacturing facilities. You will learn how to build process models and accurately simulate those models without performing tedious calculations. Divided into 12 two-hour lessons, the guide offers downloadable Aspen Plus simulation files and visual step-by-step guides. • Contains a valuable index that lists software icons and commands used in the book • Features helpful and time-saving links to instructional videos and technical content • Instructs how to integrate your simulation with other supporting software such as Aspen Capital Cost Estimator, Aspen Energy Analyzer, and Microsoft Excel • Written by an Aspen Plus power-user and leading researcher in chemical process simulations
A comprehensive look at existing technologies and processes for continuous manufacturing of pharmaceuticals As rising costs outpace new drug development, the pharmaceutical industry has come under intense pressure to improve the efficiency of its manufacturing processes. Continuous process manufacturing provides a proven solution. Among its many benefits are: minimized waste, energy consumption, and raw material use; the accelerated introduction of new drugs; the use of smaller production facilities with lower building and capital costs; the ability to monitor drug quality on a continuous basis; and enhanced process reliability and flexibility. Continuous Manufacturing of Pharmaceuticals prepares professionals to take advantage of that exciting new approach to improving drug manufacturing efficiency. This book covers key aspects of the continuous manufacturing of pharmaceuticals. The first part provides an overview of key chemical engineering principles and the current regulatory environment. The second covers existing technologies for manufacturing both small-molecule-based products and protein/peptide products. The following section is devoted to process analytical tools for continuously operating manufacturing environments. The final two sections treat the integration of several individual parts of processing into fully operating continuous process systems and summarize state-of-art approaches for innovative new manufacturing principles. Brings together the essential know-how for anyone working in drug manufacturing, as well as chemical, food, and pharmaceutical scientists working on continuous processing Covers chemical engineering principles, regulatory aspects, primary and secondary manufacturing, process analytical technology and quality-by-design Contains contributions from researchers in leading pharmaceutical companies, the FDA, and academic institutions Offers an extremely well-informed look at the most promising future approaches to continuous manufacturing of innovative pharmaceutical products Timely, comprehensive, and authoritative, Continuous Manufacturing of Pharmaceuticals is an important professional resource for researchers in industry and academe working in the fields of pharmaceuticals development and manufacturing.
