A Systems Biology Approach to Advancing Adverse Outcome Pathways for Risk Assessment

A Systems Biology Approach to Advancing Adverse Outcome Pathways for Risk Assessment

Author: Natàlia Garcia-Reyero

Publisher: Springer

Published: 2018-02-24

Total Pages: 429

ISBN-13: 3319660845

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Social pressure to minimize the use of animal testing, the ever-increasing concern on animal welfare, and the need for more human-relevant and more predictive toxicity tests are some of the drivers for new approaches to chemical screening. This book focuses on The Adverse Outcome Pathway, an analytical construct that describes a sequential chain of causally linked events at different levels of biological organization that lead to an adverse health or ecotoxicological effect. While past efforts have focused on toxicological pathway-based vision for human and ecological health assessment relying on in vitro systems and predictive models, The Adverse Outcome Pathway framework provides a simplified and structured way to organize toxicological information. Within the book, a systems biology approach supplies the tools to infer, link, and quantify the molecular initiating events and the key events and key event relationships leading to adverse outcomes. The advancement of these tools is crucial for the successful implementation of AOPs for regulatory purposes.


Responsible Marine Aquaculture

Responsible Marine Aquaculture

Author: Robert R. Stickney

Publisher: CABI

Published: 2002-01-01

Total Pages: 414

ISBN-13: 9780851998565

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With the expansion of the world aquaculture industry, there has been increasing concern over sustainability and environmental impact. This book addresses this topical issue, concentrating on marine aquaculture.


Nutrition and Feeding Strategies in Protozoa

Nutrition and Feeding Strategies in Protozoa

Author: Brenda Nisbet

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 286

ISBN-13: 9401165556

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1 Modern biologists describe protozoa as microscopic eukaryotic organ isms with a capacity for establishing themselves in almost every con ceivable habitat provided it contains moisture in some form. In 1674 at the time when Antony von Leeuwenhoek was making his first observations of 'very small animalcules' in Berkelse Mere near his home town of Delft, this concept of the ubiquity of protozoa would have been difficult to comprehend. Leeuwenhoek's curiosity later led him to examine the body fluids, gut contents and excreta of different animals and to describe 'an inconceivably great company of living animalcules, and these of divers sorts and sizes'. Here were early des criptions of parasitic protozoa, species which later came to be recog nized as Opalina, Giardia, Trichomonas and others. Following his pioneering work in the field of microscopic observation, knowledge of protozoa has accumulated at an accelerating pace. Some 30,000 living species have been identified, and an equal number of fossil species, from habitats which range from the ocean waters to the exuvial fluid of insects. The study of protozoan nutrition is a particularly interesting aspect of this expanding field of zoology. What kind of nourishment do protozoa need, how do they acqlire it, and what influence do the answers to these two questions havE on where protozoa live? The need to determine what hId of food protozoa are utilizing in their environment is desirable in al ecological studies involving micro organisms of aquatic communities.


Reproductive Biology of Crustaceans

Reproductive Biology of Crustaceans

Author: Elena Mente

Publisher: CRC Press

Published: 2008-01-04

Total Pages: 579

ISBN-13: 1439843341

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Crustaceans adapt to a wide variety of habitats and ways of life. They have a complex physiological structure particularly with regard to the processes of growth (molting), metabolic regulation, and reproduction. Crustaceans are ideal as model organisms for the study of endocrine disruption and stress physiology in aquatic invertebrates. This book


Complex Ecology

Complex Ecology

Author: Charles G. Curtin

Publisher: Cambridge University Press

Published: 2018-05-31

Total Pages: 595

ISBN-13: 1108244335

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From climate change to species extinction, humanity is confronted with an increasing array of societal and environmental challenges that defy simple quantifiable solutions. Complexity-based ecology provides a new paradigm for ecologists and conservationists keen to embrace the uncertainty that is pressed upon us. This book presents key research papers chosen by some sixty scholars from various continents, across a diverse span of sub-disciplines. The papers are set alongside first person commentary from many of the seminal voices involved, offering unprecedented access to experts' viewpoints. The works assembled also shed light on the process of science in general, showing how the shifting of wider perspectives allows for new ideas to take hold. Ideal for undergraduate and advanced students of ecology and conservation, their educators and those working across allied fields, this is the first book of its kind to focus on complexity-based approaches and provides a benchmark for future collected volumes.


Systems Biology

Systems Biology

Author: Bernhard Palsson

Publisher: Cambridge University Press

Published: 2015-01-26

Total Pages: 551

ISBN-13: 1107038855

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The first comprehensive single-authored textbook on genome-scale models and the bottom-up approach to systems biology.


Strengthening Forensic Science in the United States

Strengthening Forensic Science in the United States

Author: National Research Council

Publisher: National Academies Press

Published: 2009-07-29

Total Pages: 348

ISBN-13: 0309142393

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Scores of talented and dedicated people serve the forensic science community, performing vitally important work. However, they are often constrained by lack of adequate resources, sound policies, and national support. It is clear that change and advancements, both systematic and scientific, are needed in a number of forensic science disciplines to ensure the reliability of work, establish enforceable standards, and promote best practices with consistent application. Strengthening Forensic Science in the United States: A Path Forward provides a detailed plan for addressing these needs and suggests the creation of a new government entity, the National Institute of Forensic Science, to establish and enforce standards within the forensic science community. The benefits of improving and regulating the forensic science disciplines are clear: assisting law enforcement officials, enhancing homeland security, and reducing the risk of wrongful conviction and exoneration. Strengthening Forensic Science in the United States gives a full account of what is needed to advance the forensic science disciplines, including upgrading of systems and organizational structures, better training, widespread adoption of uniform and enforceable best practices, and mandatory certification and accreditation programs. While this book provides an essential call-to-action for congress and policy makers, it also serves as a vital tool for law enforcement agencies, criminal prosecutors and attorneys, and forensic science educators.


Ecotoxicology Modeling

Ecotoxicology Modeling

Author: James Devillers

Publisher: Springer Science & Business Media

Published: 2009-08-07

Total Pages: 400

ISBN-13: 1441901973

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Ecotoxicology Modeling is a comprehensive and well-documented text providing a collection of computational methods to the ecotoxicologists primarily interested in the study of the adverse effects of chemicals, their mechanisms of action and/or their environmental fate and behavior. Avoiding mathematical jargon, the book presents numerous case studies to enable the reader to understand the interest but also the limitations of linear and nonlinear models in ecotoxicology. Written by an international team of scientists, Ecotoxicology Modeling is of primary interest to those whose research or professional activity is directly concerned with the development and application of models in ecotoxicology. It is also intended to provide the graduate and post-graduate students with a clear and accessible text covering the main types of modeling approaches used in environmental sciences.