This book covers intentional design aspects for combinations of drugs, single-molecule hybrids with potential or actual multiple actions, pro-drugs which could yield multiple activity outcomes, and future possibilities. The approach of the book is interdisciplinary, and it provides greater understanding of the complex interplay of factors involved in the medicinal chemistry design and laboratory development of multiply active antibacterials. The scope of the book appeals to readers who are researching in the field of antibacterials using the approach of medicinal chemistry design and drug development.
Drug-Induced Liver Injury, Volume 85, the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this new release include Cell death mechanisms in DILI, Mitochondria in DILI, Primary hepatocytes and their cultures for the testing of drug-induced liver injury, MetaHeps an alternate approach to identify IDILI, Autophagy and DILI, Biomarkers and DILI, Regeneration and DILI, Drug-induced liver injury in obesity and nonalcoholic fatty liver disease, Mechanisms of Idiosyncratic Drug-Induced Liver Injury, the Evaluation and Treatment of Acetaminophen Toxicity, and much more. - Includes the authority and expertise of leading contributors in pharmacology - Presents the latest release in the Advances in Pharmacology series
The Model Rules of Professional Conduct provides an up-to-date resource for information on legal ethics. Federal, state and local courts in all jurisdictions look to the Rules for guidance in solving lawyer malpractice cases, disciplinary actions, disqualification issues, sanctions questions and much more. In this volume, black-letter Rules of Professional Conduct are followed by numbered Comments that explain each Rule's purpose and provide suggestions for its practical application. The Rules will help you identify proper conduct in a variety of given situations, review those instances where discretionary action is possible, and define the nature of the relationship between you and your clients, colleagues and the courts.
This report from the Committee on Military Nutrition Research reviews the history of caffeine usage, the metabolism of caffeine, and its physiological effects. The effects of caffeine on physical performance, cognitive function and alertness, and alleviation of sleep deprivation impairments are discussed in light of recent scientific literature. The impact of caffeine consumption on various aspects of health, including cardiovascular disease, reproduction, bone mineral density, and fluid homeostasis are reviewed. The behavioral effects of caffeine are also discussed, including the effect of caffeine on reaction to stress, withdrawal effects, and detrimental effects of high intakes. The amounts of caffeine found to enhance vigilance and reaction time consistently are reviewed and recommendations are made with respect to amounts of caffeine appropriate for maintaining alertness of military personnel during field operations. Recommendations are also provided on the need for appropriate labeling of caffeine-containing supplements, and education of military personnel on the use of these supplements. A brief review of some alternatives to caffeine is also provided.
Drug overdose, driven largely by overdose related to the use of opioids, is now the leading cause of unintentional injury death in the United States. The ongoing opioid crisis lies at the intersection of two public health challenges: reducing the burden of suffering from pain and containing the rising toll of the harms that can arise from the use of opioid medications. Chronic pain and opioid use disorder both represent complex human conditions affecting millions of Americans and causing untold disability and loss of function. In the context of the growing opioid problem, the U.S. Food and Drug Administration (FDA) launched an Opioids Action Plan in early 2016. As part of this plan, the FDA asked the National Academies of Sciences, Engineering, and Medicine to convene a committee to update the state of the science on pain research, care, and education and to identify actions the FDA and others can take to respond to the opioid epidemic, with a particular focus on informing FDA's development of a formal method for incorporating individual and societal considerations into its risk-benefit framework for opioid approval and monitoring.
Much expanded, fully revised, and with many more new illustrations, this remains the essential text for anyone who has to master the complexities of psychopharmacology.
Small Signal Audio Design is a highly practical handbook providing an extensive repertoire of circuits that can be assembled to make almost any type of audio system. The publication of Electronics for Vinyl has freed up space for new material, (though this book still contains a lot on moving-magnet and moving-coil electronics) and this fully revised third edition offers wholly new chapters on tape machines, guitar electronics, and variable-gain amplifiers, plus much more. A major theme is the use of inexpensive and readily available parts to obtain state-of-the-art performance for noise, distortion, crosstalk, frequency response accuracy and other parameters. Virtually every page reveals nuggets of specialized knowledge not found anywhere else. For example, you can improve the offness of a fader simply by adding a resistor in the right place- if you know the right place. Essential points of theory that bear on practical audio performance are lucidly and thoroughly explained, with the mathematics kept to an absolute minimum. Self’s background in design for manufacture ensures he keeps a wary eye on the cost of things. This book features the engaging prose style familiar to readers of his other books. You will learn why mercury-filled cables are not a good idea, the pitfalls of plating gold on copper, and what quotes from Star Trek have to do with PCB design. Learn how to: make amplifiers with apparently impossibly low noise design discrete circuitry that can handle enormous signals with vanishingly low distortion use humble low-gain transistors to make an amplifier with an input impedance of more than 50 megohms transform the performance of low-cost-opamps build active filters with very low noise and distortion make incredibly accurate volume controls make a huge variety of audio equalisers make magnetic cartridge preamplifiers that have noise so low it is limited by basic physics, by using load synthesis sum, switch, clip, compress, and route audio signals be confident that phase perception is not an issue This expanded and updated third edition contains extensive new material on optimising RIAA equalisation, electronics for ribbon microphones, summation of noise sources, defining system frequency response, loudness controls, and much more. Including all the crucial theory, but with minimal mathematics, Small Signal Audio Design is the must-have companion for anyone studying, researching, or working in audio engineering and audio electronics.
This reference discusses how automata and language theory can be used to understand solutions to solving equations in groups and word problems in groups. Examples presented include, how Fine scale complexity theory has entered group theory via these connections and how cellular automata, has been generalized into a group theoretic setting. Chapters written by experts in group theory and computer science explain these connections.
