At the present time, 430 drugs are known to cause respiratory injury. This represents an increase of almost 200 in the last ten years, and the number is still increasing. This comprehensive, definitive reference work, with an outstanding range of international expert contributors and two of the world's leading editors, provides an essential referen
This book covers various aspects of a respiratory system disorder associated with prescribed drugs that do not yet have established treatment guidelines, and for which the only treatment is to discontinue taking the drug. Very little clinical evidence regarding the disorder is available, since randomized trials cannot to be carried out, the onset of the disorder cannot be predicted, and the resulting pathological condition is life-threatening. However, the need for an established treatment continues to grow due to the introduction of many new drugs, such as anti-neoplastic drugs, biological products, and molecular target drugs, the adverse effects of which are difficult to differentiate from those of other lung diseases, such as lung infectious diseases. Drug-Induced Lung Injury offers a highly beneficial resource not only for respiratory physicians but also all medical clinicians who prescribe drugs, nurses, pharmacists and pharmaceutical scientists. Written by pioneering experts in the field, the book examines a wealth of cases and the insights they yield concerning the diagnosis, treatment and specific drugs causing the disease. It not only fosters a deeper understanding of the disorder but also highlights the current challenges and paves the way for future clinical research.
This major reference work is the most comprehensive resource on oncologic critical care. The text reviews all significant aspects of oncologic ICU practices, with a particular focus on challenges encountered in the diagnosis and management of the critically ill cancer patient population. Comprised of over 140 chapters, the text explores such topics as the organization and management of an oncologic ICU, diseases and complications encountered in the oncologic ICU, multidisciplinary care, surgical care, transfusion medicine, special patient populations, critical care procedures, ethics, pain management, and palliative care. Written by worldwide experts in the field, Oncologic Critical Care is a valuable resource for intensivists, advance practice providers, nurses, and other healthcare providers, that will help close significant knowledge and educational gaps within the realm of medical care for critically ill cancer patients.
Difficult to Diagnose Rare Diffuse Lung Disease presents the theoretical basis and practical aspects of differential diagnoses of rare lung diseases with the use of new method of probe-based confocal laser endomicroscopy (alveoscopy) of the distal respiratory region. Each chapter describes signs and symptoms of the disease and its typical and atypical manifestations. The book contains full color illustrations, including high-resolution histological microphotographs, CT-scans and confocal laser endomicroscopy images. In combination, these elements make this book an invaluable reference and guide for pulmonary researchers, pulmonologists, radiologists, and pathologists who wish to broaden their spectrum of knowledge in rare lung diseases. - Highlights the new method of probe-based confocal laser endomicroscopy (alveoscopy) of the distal respiratory region, opening new horizons in the minimally invasive diagnosis of lung diseases - Discusses current treatment strategies in accordance with clinical guidelines, including data from the latest clinical trials - Presented in tabular format to aid in the diagnostic process
Data Mining Applications in Engineering and Medicine targets to help data miners who wish to apply different data mining techniques. Data mining generally covers areas of statistics, machine learning, data management and databases, pattern recognition, artificial intelligence, etc. In this book, most of the areas are covered by describing different applications. This is why you will find here why and how Data Mining can also be applied to the improvement of project management. Since Data Mining has been widely used in a medical field, this book contains different chapters reffering to some aspects and importance of its use in the mentioned field: Incorporating Domain Knowledge into Medical Image Mining, Data Mining Techniques in Pharmacovigilance, Electronic Documentation of Clinical Pharmacy Interventions in Hospitals etc. We hope that this book will inspire readers to pursue education and research in this emerging field.
This reference surveys current best practices in the prevention and management of ventilator-induced lung injury (VILI) and spans the many pathways and mechanisms of VILI including cell injury and repair, the modulation of alveolar-capillary barrier properties, and lung and systemic inflammatory consequences of injurous mechanical ventilation. Cons
This book is a comprehensive and easy-to-read guide to pulmonary imaging. Medical Imaging is one of the cornerstones of modern medicine, and nowhere is this more apparent than pulmonary disease. We have come a long way from the days of chest radiography, though the chest radiograph still remains the single most common imaging test ordered worldwide. Pulmonary disease is now routinely evaluated with ultra-modern computed tomography (CT), magnetic resonance imaging (MRI) and positron emission tomography (PET) scanners, while ultrasonography plays a limited role in critical care and pleural/chest wall diseases. Rapid advancements in the sub-specialty of chest imaging and an exponential increase in the knowledge of pulmonary disease have led to an increasing demand for a comprehensive yet easily digestible handbook of pulmonary imaging, which prepackages knowledge in a form that can be easily understood and readily visualized with high-quality representative images. This book answers that need by providing the most important, relevant medical knowledge needed to handle pulmonary cases. It is divided into two sections, neoplastic disease and non-neoplastic disease. Chapters detail essential information about each disease, including presentation and the different modalities used to accurately diagnose and/or plan treatment. Major topics that are covered include bronchogenic carcinoma and other lung tumors, COPD, ILD, developmental lung disorders, pulmonary hypertension, and pulmonary infections. Each chapter includes extensive radiographic images to give a complete perspective on how these diseases present. Readers can easily see what the radiology of a particular disease entity looks like, what would be the differential diagnoses for a particular imaging abnormality, and compare the bullet review points associated with an image to their particular case. This is an ideal guide for general and thoracic radiologists, pulmonary, sleep medicine, and critical care specialists, thoracic surgeons, as well as residents and all clinicians who treat patients with pulmonary disease.
Drug-Induced Liver Injury, Volume 85, the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this new release include Cell death mechanisms in DILI, Mitochondria in DILI, Primary hepatocytes and their cultures for the testing of drug-induced liver injury, MetaHeps an alternate approach to identify IDILI, Autophagy and DILI, Biomarkers and DILI, Regeneration and DILI, Drug-induced liver injury in obesity and nonalcoholic fatty liver disease, Mechanisms of Idiosyncratic Drug-Induced Liver Injury, the Evaluation and Treatment of Acetaminophen Toxicity, and much more. - Includes the authority and expertise of leading contributors in pharmacology - Presents the latest release in the Advances in Pharmacology series
This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
With an emphasis on practical diagnostic problem solving, Pathology of the Lungs, 3rd Edition provides the pulmonary pathologist and the general surgical pathologist with an accessible, comprehensive guide to the recognition and interpretation of common and rare neoplastic and non-neoplastic lung conditions. The text is written by two authors and covers all topics in a consistent manner without the redundancies or lapses that are common in multi-authored texts. The text is lavishly illustrated with the highest quality illustrations which accurately depict the histologic, immunohistochemical and cytologic findings under consideration and it is supplemented throughout with practical tips and advice from two internationally respected experts. The user-friendly design and format allows rapid access to essential information and the incorporation throughout of relevant clinical and radiographic information makes it a complete diagnostic resource inside the reporting room. Approximately 1,000 high quality full color illustrations.Provides the user with a complete visual guide to each specimen and assists in the recognition and diagnosis of any slide looked at under the microscope. Comprehensive coverage of both common and rare lung diseases and disorders. One stop consultation resource for the reporting room or study, no need to go further to get questions answered. Clinical background and ancillary radiographs incorporated throughout.Provides the user with all of the necessary diagnostic tools to make a complete and accurate pathologic report. Practical advice and tips from two of the world’s recognized experts. Provides the trainee and general surgical pathologist with time saving diagnostic clues when dealing with difficult specimens. Consistent and uniform approach incorporated for each disease and disorder (Etiology, pathogenesis, clinical features, pathologic features, differential diagnosis) User-friendly format enables quick and easy navigation to the key information required. Extensive use of summary tables, charts and graphs throughout the text. Helps simplify and clarify complex concepts and facilitates “at a glance comparisons between entities. Extensive reference list highlights landmark articles as well as including most up-to-date citations. Directs the trainee and practitioner to the most recent and authoritative sources for further reading and investigation
