Double Blind
Double Blind

Author: Edward St. Aubyn

Publisher: Farrar, Straus and Giroux

Published: 2021-06-01

Total Pages: 256

ISBN-13: 0374717478

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Double Blind follows three close friends and their circle through a year of extraordinary transformation. Set inLondon, Cap d'Antibes, Big Sur, and a rewilded corner of Sussex, this thrilling, ambitious novel is about the headlong pursuit of knowledge—for the purposes of pleasure, revelation, money, sanity, or survival—and the consequences of fleeing from what we know about others and ourselves. When Olivia meets a new lover just as she is welcoming her best friend, Lucy, back from New York, her dedicated academic life expands precipitously. Her connection to Francis, a committed naturalist living off the grid, is immediate and startling. Eager to involve Lucy in her joy, Olivia introduces the two—but Lucy has received shocking news of her own that binds the trio unusually close. Over the months that follow, Lucy’s boss, Hunter, Olivia’s psychoanalyst parents, and a young man named Sebastian are pulled into the friends’ orbit, and not one of them will emerge unchanged. Expansive, playful, and compassionate, Edward St. Aubyn's Double Blind investigates themes of inheritance, determinism, freedom, consciousness, and the stories we tell about ourselves. It is as compelling about ecology, psychoanalysis, genetics, and neuroscience as it is about love, fear, and courage. Most of all, it is a perfect expression of the interconnections it sets out to examine, and a moving evocation of an imagined world that is deeply intelligent, often tender, curious, and very much alive.

Doubleblind
Doubleblind

Author: Ann Aguirre

Publisher: Penguin

Published: 2009-09-29

Total Pages: 284

ISBN-13: 1101140364

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View our feature on Ann Aguirre’s Doubleblind.As a “Jumper” who navigates ships through grimspace, Sirantha Jax is used to kicking ass. So why is she suddenly chosen as an ambassador of peace?

Planning Clinical Research
Planning Clinical Research

Author: Robert A. Parker

Publisher: Cambridge University Press

Published: 2016-10-12

Total Pages: 445

ISBN-13: 0521840635

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Planning clinical research requires many decisions. The authors of this book explain key decisions with examples showing what works and what does not.

Field Trials of Health Interventions
Field Trials of Health Interventions

Author: Peter G. Smith

Publisher:

Published: 2015

Total Pages: 479

ISBN-13: 0198732864

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This is an open access title available under the terms of a CC BY-NC 4.0 International licence. It is free to read at Oxford Scholarship Online and offered as a free PDF download from OUP and selected open access locations. Before new interventions are released into disease control programmes, it is essential that they are carefully evaluated in field trials'. These may be complex and expensive undertakings, requiring the follow-up of hundreds, or thousands, of individuals, often for long periods. Descriptions of the detailed procedures and methods used in the trials that have been conducted have rarely been published. A consequence of this, individuals planning such trials have few guidelines available and little access to knowledge accumulated previously, other than their own. In this manual, practical issues in trial design and conduct are discussed fully and in sufficient detail, that Field Trials of Health Interventions may be used as a toolbox' by field investigators. It has been compiled by an international group of over 30 authors with direct experience in the design, conduct, and analysis of field trials in low and middle income countries and is based on their accumulated knowledge and experience. Available as an open access book via Oxford Medicine Online, this new edition is a comprehensive revision, incorporating the new developments that have taken place in recent years with respect to trials, including seven new chapters on subjects ranging from trial governance, and preliminary studies to pilot testing.

The Double Bind
The Double Bind

Author: Chris Bohjalian

Publisher: Vintage

Published: 2008-02-12

Total Pages: 418

ISBN-13: 0307389413

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NATIONAL BESTSELLER • From the bestselling author of The Flight Attendant, here is a gripping psychological novel of obsession and consequence. When Laurel Estabrook is attacked while riding her bicycle through Vermont’s back roads, her life is forever changed. Formerly outgoing, Laurel withdraws into her photography, spending all her free time at a homeless shelter. There she meets Bobbie Crocker, a man with a history of mental illness and a box of photographs that he won’t let anyone see. When Bobbie dies, Laurel discovers a deeply hidden secret–a story that leads her far from her old life, and into a cat-and-mouse game with pursuers who claim they want to save her. In a tale that travels between the Roaring Twenties and the twenty-first century, between Jay Gatsby’s Long Island and rural New England, bestselling author Chris Bohjalian has written an extraordinary novel. Look for Chris Bohjalian's new novel, The Lioness!

Double Blind
Double Blind

Author: Heidi Cullinan

Publisher: Heidi Cullinan

Published: 2017-06-10

Total Pages:

ISBN-13: 9781945116131

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Know when to show your hand…and when to hedge your bets. Randy Jansen can’t stand to just sit by and watch as a mysterious man throws money away on the roulette wheel, especially since Randy’s got his own bet going as to the reason this guy is making every play like it’s his last day on earth. The man’s dark desperation hits Randy right in the gut. Half of him warns that getting involved is a sucker’s bet, and the other half scrambles for a reason—any reason—to save the man’s soul. Ethan Ellison has no idea what he’s going to do with himself once his last dollar is gone—until Randy whirls into his life with a heart-stealing smile and a poker player’s gaze that sees too much. Randy draws Ethan into a series of wagers that leads to a scorching kiss by midnight, but he isn’t the only one with an interest in Ethan’s vulnerability. Soon they’re both taking risks that not only play fast and loose with the law, but with the biggest prize of all: their hearts.

Small Clinical Trials
Small Clinical Trials

Author: Institute of Medicine

Publisher: National Academies Press

Published: 2001-01-01

Total Pages: 221

ISBN-13: 0309171148

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Clinical trials are used to elucidate the most appropriate preventive, diagnostic, or treatment options for individuals with a given medical condition. Perhaps the most essential feature of a clinical trial is that it aims to use results based on a limited sample of research participants to see if the intervention is safe and effective or if it is comparable to a comparison treatment. Sample size is a crucial component of any clinical trial. A trial with a small number of research participants is more prone to variability and carries a considerable risk of failing to demonstrate the effectiveness of a given intervention when one really is present. This may occur in phase I (safety and pharmacologic profiles), II (pilot efficacy evaluation), and III (extensive assessment of safety and efficacy) trials. Although phase I and II studies may have smaller sample sizes, they usually have adequate statistical power, which is the committee's definition of a "large" trial. Sometimes a trial with eight participants may have adequate statistical power, statistical power being the probability of rejecting the null hypothesis when the hypothesis is false. Small Clinical Trials assesses the current methodologies and the appropriate situations for the conduct of clinical trials with small sample sizes. This report assesses the published literature on various strategies such as (1) meta-analysis to combine disparate information from several studies including Bayesian techniques as in the confidence profile method and (2) other alternatives such as assessing therapeutic results in a single treated population (e.g., astronauts) by sequentially measuring whether the intervention is falling above or below a preestablished probability outcome range and meeting predesigned specifications as opposed to incremental improvement.

Dynamics of Brain Edema
Dynamics of Brain Edema

Author: Hanna M. Pappius

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 456

ISBN-13: 3642665241

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A workshop on Dynamic Aspects of Cerebral Edema was organized to pro vide an opport~nitY,for interdisciplinary and detailed consideration of this subject, so crucial in neurology and neurosurgery. The previ ous workshops were held in Vienna in 1965 and in Mainz in 1972. In the meantime, our ideas on mechanisms of resolution of cerebral edema had been changing drastically. Controversy had arisen regarding the role of biogenic amines in the development of edema. Active work in several centers had indicated the possibility of a reversible compo nent in edematous changes associated with ischemia, the control of which could be of therapeutic significance in the problem of stroke. It was felt that a thorough discussion, at this time, by those involv ed in these various studies should help to resolve the controversies, to crystallize the implications of the new findings, and to evaluate their application for patient care. In preparing the proceedings for publication we have edited the manu scripts and selected the discussions with an aim to highlight new find ings, to make this volume readable, and to eliminate duplication. We gratefully acknowledge financial support from the institutions and organizations previously listed. Many individuals contributed to the success of the workshop and the preparation of the proceedings for publication. Doctors J.B. Brierley, I. Klatzo, H.J. Reulen, and A.G.

The Double-Blind Ghost Box
The Double-Blind Ghost Box

Author: Shawn Taylor

Publisher: iUniverse

Published: 2013-04

Total Pages: 197

ISBN-13: 1475985290

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In recent years, the paranormal has gained new footing as reality television has grabbed onto this research and created a cultural frenzy around it. There are those who are skeptics, those who believe, and those who seek to prove the existence of the paranormal. In The Double-Blind Ghost Box, authors Shawn Taylor and Daniel Morgan share their research and personal experiences with the paranormal, focusing on the development and use of the ghost box, a device that can establish a two-way communication beyond death’s veil. The Double-Blind Ghost Box reviews the process of Taylor and Morgan’s studies of the device, along with how they determined its usefulness in researching the paranormal. They explore the history of the ghost box and the issues arising in today’s ghost box methods, and they offer methods for conducting an objective ghost box investigation, processing ghost box evidence, analyzing the findings, and presenting the results to clients. Taylor and Morgan also discuss the different spirits an investigation might uncover and future ghost box applications and technologies. Sharing actual transcripts of investigations, The Double-Blind Ghost Box works toward communicating the existence of the paranormal through objective research. Shawn Taylor has a technical background in computer hardware, software, programming, digital media, Six Sigma problem solving, statistical analysis, psychology, and counseling. Daniel Morgan earned degrees in behavioral science and electrical engineering.