The interactions of DNA with force are central to manifold fields of inquiry, including the de novo design of DNA nanostructures, the use of DNA to probe the principles of biological self-assembly, and the operation of cellular nanomachines. This work presents a survey of three distinct ways coarse-grained simulations can help characterize these interactions. A non-equilibrium energy landscape reconstruction technique is validated for use with the oxDNA model and a practical framework to guide future applications is established. A novel method for calculating entropic forces in DNA molecules is outlined and contrasted with existing, flawed approaches. Finally, a joint experimental-simulation study of large DNA origami nanostructures under force sheds light on design principles and, through vivid illustrations, their unfolding process. This text provides an accessible and exciting launching point for any student interested in the computational study of DNA mechanics and force interactions.
Are you tired of feeling like your best years are behind you? Do you fear the thought of aging and its effects on your body and mind? Are you interested in learning about the science behind aging and the potential solutions to combat it? In "Aging: Science, Solutions, and the Future," we explore the biological basis of aging, current anti-aging technologies, the role of nutrition, exercise, hormones, genetics, stress, the immune system, the brain, and potential future technologies in the aging process. This book provides a comprehensive look at how our bodies change as we age and what we can do to maximize our healthspan. By reading this book, you will gain a deeper understanding of: - The biological factors that contribute to aging and how they affect your body and mind. - Current and future anti-aging technologies and therapies. - How nutrition and exercise can help you age more gracefully and healthily. - The role of hormones in aging and how hormonal balance can impact your vitality. - The science behind telomeres and the potential for telomere therapy. - The genetic factors that influence our lifespan and the potential for genetic therapies. - How chronic stress affects our bodies and minds and strategies to manage it effectively. - The changes in the immune system as we age and what this means for our health and longevity. - How the brain changes as we age and what this means for cognitive function and dementia. If you want to understand the science behind aging and discover the potential solutions to combat its effects, then buy "Aging: Science, Solutions, and the Future" today. Take control of your health and maximize your potential for a long, fulfilling life.
Are you tired of being unheard in a society that claims to be equal? Have you been falsely accused of abuse or denied your basic rights? This book is for YOU. The Silent Victims exposes the hidden injustices faced by men in today's society, providing a voice to the voiceless. - False Allegations: Uncover the truth behind baseless accusations that destroy men's lives. - Sexual Abuse: Hear the stories of men who have been victims, and learn about the societal stigma attached to male survivors. - Misogyny and Misandry: Explore the extreme misogyny that impacts men in various aspects of life. - Denied Due Process: Expose cases where men have been denied their right to a fair trial. - Guilty Until Proven Innocent: Discover the presumption of guilt placed on men, especially in cases involving women. - Police and Social Services: Learn about incidents where men have been mistreated or falsely accused due to societal prejudices. - Health Care and Public Education System: Examine the structural inequalities that disadvantage men. - Wrongful Profiling: Uncover how men are profiled as perpetrators when they are victims. - Closed and Secret Family Courts: Expose the injustices faced by men in these courts. - Hearsay and Children's Testimony: Discover how these are used against men, and the consequences of such practices. If you want to understand the hidden injustices faced by men and fight for your rights, then buy this book today. Silent Victims is your guide to navigating and challenging the systems that have overlooked you for far too long.
Written by experts in their respective fields, this book reviews the expanding knowledge concerning the mechanisms regulating male reproduction at the molecular and cellular levels. It covers the development of the testes and regulatory controls for spermatogenesis and steroidogenesis, and it considers aspects of Sertoli cell function. Areas of emphasis include communication between the various cell types involved in reproduction by hormone and growth factors and the mechanisms by which these factors regulate gene expression. A number of mammalian systems, including humans, are covered. The carefully selected authors provide a clear synopsis of the concepts in each area as well as the latest references, enabling the reader to investigate the topic further. This book is of interest to those seeking an understanding of the regulatory mechanisms in male reproduction and is written for the graduate and postgraduate levels. - Provides up-to-date reviews of the molecular and cellular biology of male reproduction - Includes chapters on the developmental biology of the testes - Links conventional hormonal control of testicular function with the evolving role of growth factors and proto-oncogenes
A coherent and comprehensive theory of life that synthesizes the specific properties of living organisms. Despite continued advances, science has until now struggled to describe the specific properties that define a living being. By synthesizing several aspects of organismic biology and contemporary science, Properties of Life by Bernd Rosslenbroich generates a coherent concept of the singular quality of being alive—a concept that provides a crucial foundation for scientists, farmers, and medical practitioners and helps explain how we all interact with the world around us and within ourselves. Is an organism an aggregate of parts or an integrated system with agency? Is it a passive stimulus-response machine or a being equipped with subjectivity and consciousness? Rosslenbroich argues that the way people in different fields understand life determines their assumptions about organic function and behavior. In medicine, this extends to the human organism, which influences prevention, diagnosis, and treatment. Drawing attention to a long-standing but underappreciated line of thought in organismic biology, Rosslenbroich’s original idea emphasizes the autonomy of living processes, their network characteristics, and their self-determined organization in time and structure. A timely and revelatory book, Properties of Life formulates an integrated, unified theory that remains flexible enough to accommodate future developments and resilient enough to withstand the challenges of different theoretical and disciplinary backgrounds.
Biophysics is a rapidly-evolving interdisciplinary science that applies theories and methods of the physical sciences to questions of biology. Biophysics encompasses many disciplines, including physics, chemistry, mathematics, biology, biochemistry, medicine, pharmacology, physiology, and neuroscience, and it is essential that scientists working in these varied fields are able to understand each other's research. Comprehensive Biophysics, Nine Volume Set will help bridge that communication gap. Written by a team of researchers at the forefront of their respective fields, under the guidance of Chief Editor Edward Egelman, Comprehensive Biophysics, Nine Volume Set provides definitive introductions to a broad array of topics, uniting different areas of biophysics research - from the physical techniques for studying macromolecular structure to protein folding, muscle and molecular motors, cell biophysics, bioenergetics and more. The result is this comprehensive scientific resource - a valuable tool both for helping researchers come to grips quickly with material from related biophysics fields outside their areas of expertise, and for reinforcing their existing knowledge. Biophysical research today encompasses many areas of biology. These studies do not necessarily share a unique identifying factor. This work unites the different areas of research and allows users, regardless of their background, to navigate through the most essential concepts with ease, saving them time and vastly improving their understanding The field of biophysics counts several journals that are directly and indirectly concerned with the field. There is no reference work that encompasses the entire field and unites the different areas of research through deep foundational reviews. Comprehensive Biophysics fills this vacuum, being a definitive work on biophysics. It will help users apply context to the diverse journal literature offering, and aid them in identifying areas for further research Chief Editor Edward Egelman (E-I-C, Biophysical Journal) has assembled an impressive, world-class team of Volume Editors and Contributing Authors. Each chapter has been painstakingly reviewed and checked for consistent high quality. The result is an authoritative overview which ties the literature together and provides the user with a reliable background information and citation resource
This in-depth, multidisciplinary analysis of the latest research adds a new theoretical interpretation to the role of variability in movement behaviour. Many scientific disciplines are represented in the text and each chapter examines a range of topics.
This textbook provides an introduction to the fundamental and applied aspects of biophysics for advanced undergraduate and graduate students of physics, chemistry, and biology. The application of physics principles and techniques in exploring biological systems has long been a tradition in scientific research. Biological systems hold naturally inbuilt physical principles and processes which are popularly explored. Systematic discoveries help us understand the structures and functions of individual biomolecules, biomolecular systems, cells, organelles, tissues, and even the physiological systems of animals and plants. Utilizing a physics- based scientific understanding of biological systems to explore disease is at the forefront of applied scientific research. This textbook covers key breakthroughs in biophysics whilst looking ahead to future horizons and directions of research. It contains models based on both classical and quantum mechanical treatments of biological systems. It explores diseases related to physical alterations in biomolecular structures and organizations alongside drug discovery strategies. It also discusses the cutting- edge applications of nanotechnologies in manipulating nanoprocesses in biological systems. Key Features: • Presents an accessible introduction to how physics principles and techniques can be used to understand biological and biochemical systems. • Addresses natural processes, mutations, and their purposeful manipulation. • Lays the groundwork for vitally important natural scientific, technological, and medical advances. Mohammad Ashrafuzzaman, a biophysicist and condensed matter scientist, is passionate about investigating biological and biochemical processes utilizing physics principles and techniques. He is a professor of biophysics at King Saud University’s Biochemistry Department in the College of Science, Riyadh, Saudi Arabia; the co- founder of MDT Canada Inc., and the founder of Child Life Development Institute, Edmonton, Canada. He has authored Biophysics and Nanotechnology of Ion Channels, Nanoscale Biophysics of the Cell, and Membrane Biophysics. He has also published about 50 peer- reviewed articles and several patents, edited two books, and has been serving on the editorial boards of Elsevier and Bentham Science journals. Dr. Ashrafuzzaman has held research and academic ranks at Bangladesh University of Engineering & Technology, University of Neuchatel (Switzerland), Helsinki University of Technology (Finland), Weill Medical College of Cornell University (USA), and University of Alberta (Canada). During 2013– 2018 he also served as a Visiting Professor at the Departments of Oncology, and Medical Microbiology and Immunology, of the University of Alberta. Dr. Ashrafuzzaman earned his highest academic degree, Doctor of Science (D.Sc.) in condensed matter physics from the University of Neuchatel, Switzerland in 2004.
In its beautiful simplicity, the double-helicaln stucture of DNA had entranced us into believing that we can fully understand the information content of a DNA sequence, simply by treating it as text that is read in a linear fashion. While we have learned much based on this assumption, there is much we have missed. Far from a passive tape running through a reader, genomes contain information that appears in new forms which create regions with distinct behavior. The chapters in this volume touch on one or more of three interconnected themes; information can be implied, rather than explicit, in a genome; information can lead to focused and/or regulated changes in nucleotide sequences; information that affects the probability of distinct classes of mutation has implications for evolutionary theory.
This classroom-tested textbook is an innovative, comprehensive, and forward-looking introductory undergraduate physics course. While it clearly explains physical principles and equips the student with a full range of quantitative tools and methods, the material is firmly grounded in biological relevance and is brought to life with plenty of biological examples throughout. It is designed to be a self-contained text for a two-semester sequence of introductory physics for biology and premedical students, covering kinematics and Newton’s laws, energy, probability, diffusion, rates of change, statistical mechanics, fluids, vibrations, waves, electromagnetism, and optics. Each chapter begins with learning goals, and concludes with a summary of core competencies, allowing for seamless incorporation into the classroom. In addition, each chapter is replete with a wide selection of creative and often surprising examples, activities, computational tasks, and exercises, many of which are inspired by current research topics, making cutting-edge biological physics accessible to the student.
