In Vitro-In Vivo Correlations
In Vitro-In Vivo Correlations

Author: David B. Young

Publisher: Springer Science & Business Media

Published: 2013-03-08

Total Pages: 299

ISBN-13: 1468460366

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This book represents the invited presentations and some of the posters presented at the conference entitled "In Vitro-In Vivo Relationship (IVIVR) Workshop" held in Sep tember, 1996. The workshop was organized by the IVIVR Cooperative Working Group which has drawn together scientists from a number of organizations and institutions, both academic and industrial. In addition to Elan Corporation, which is a drug delivery com pany specializing in the development of ER (Extended Release) dosage forms, the IVIVR Cooperative Working Group consists of collaborators from the University of Maryland at Baltimore, University College Dublin, Trinity College Dublin, and the University of Not tingham in the UK. The principal collaborators are: Dr. Jackie Butler, Elan Corporation Prof. Owen Corrigan, Trinity College Dublin Dr. lain Cumming, Elan Corporation Dr. John Devane, Elan Corporation Dr. Adrian Dunne, University College Dublin Dr. Stuart Madden, Elan Corporation Dr. Colin Melia, University of Nottingham Mr. Tom O'Hara, Elan Corporation Dr. Deborah Piscitelli, University of Maryland at Baltimore Dr. Araz Raoof, Elan Corporation Mr. Paul Stark, Elan Corporation Dr. David Young, University of Maryland at Baltimore The purpose of the workshop was to discuss new concepts and methods in the devel opment of in vitro-in vivo relationships for ER products. The original idea went back ap proximately 15 months prior to the workshop itself. For some time, the principal collaborators had been working together on various aspects of dosage form development.

Iron in Soils and Clay Minerals
Iron in Soils and Clay Minerals

Author: J.W. Stucki

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 903

ISBN-13: 9400940076

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Probably more than any other element, iron markedly influences the chemical and physical properties of soils and sediments in the earth. Considering its transition metal status, with potential variation in electronic configuration, ionic radius, and magnetic moment, combined with its abundance and relatively large mass, little wonder that one sees its unique influence on every hand. Pre sentations at the NATO Advanced Study Institute (NATO AS!) on Iron in Soils and Clay Minerals reviewed and discussed the occurrence, behavior, and properties of Fe-bearing minerals found in soils and in the clay mineral groups kaolinite, smectite, and mica. Also discussed at the NATO AS! were the basic chemical properties of Fe, methods for separating and identifying Fe in minerals, and the role of Fe minerals in weathering and other soil-forming processes. The present publication is the reviewed and edited proceedings of that Advanced Study Institute. The sequence of chapters follows the general pattern beginning with introductory chapters which overview the general occurrence of Fe in the earth and its chemistry, both generally and in mineral environments, followed by identification and characterization methods for Fe and Fe phases in minerals. The properties and behavior of Fe oxides, Fe-bearing clay minerals, and other Fe minerals in soils are then described, and the text ends with a summary of the role of Fe in soil-forming processes. A Table of Contents and subject index are provided to assist the reader in finding specific topics within the text.

Poorly Soluble Drugs
Poorly Soluble Drugs

Author: Gregory K. Webster

Publisher: CRC Press

Published: 2017-01-06

Total Pages: 578

ISBN-13: 1315340860

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This book is the first text to provide a comprehensive assessment of the application of fundamental principles of dissolution and drug release testing to poorly soluble compounds and formulations. Such drug products are, vis-à-vis their physical and chemical properties, inherently incompatible with aqueous dissolution. However, dissolution methods are required for product development and selection, as well as for the fulfillment of regulatory obligations with respect to biopharmaceutical assessment and product quality understanding. The percentage of poorly soluble drugs, defined in classes 2 and 4 of the Biopharmaceutics Classification System (BCS), has significantly increased in the modern pharmaceutical development pipeline. This book provides a thorough exposition of general method development strategies for such drugs, including instrumentation and media selection, the use of compendial and non-compendial techniques in product development, and phase-appropriate approaches to dissolution development. Emerging topics in the field of dissolution are also discussed, including biorelevant and biphasic dissolution, the use on enzymes in dissolution testing, dissolution of suspensions, and drug release of non-oral products. Of particular interest to the industrial pharmaceutical professional, a brief overview of the formulation and solubilization techniques employed in the development of BCS class 2 and 4 drugs to overcome solubility challenges is provided and is complemented by a collection of chapters that survey the approaches and considerations in developing dissolution methodologies for enabling drug delivery technologies, including nanosuspensions, lipid-based formulations, and stabilized amorphous drug formulations.

Analysis of Pharmaceuticals by Capillary Electrophoresis
Analysis of Pharmaceuticals by Capillary Electrophoresis

Author: Kevin D. Altria

Publisher: Springer Science & Business Media

Published: 2013-04-17

Total Pages: 300

ISBN-13: 3322850110

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Dieser erste Titel einer ganzen Serie von anwendungsbezogenen Handbüchern zur Kapillarelektrophorese beschäftigt sich mit der Analytik von pharmazeutischen Substanzen. Dabei werden verschiedene Techniken praxisnah erläutert. Jeder, der im Labor - ob wissenschaftlich oder praxisnah - mit der Analyse von oft chiralen Pharmazeutika konfrontiert ist, wird viele Hinweise und Tips für seine Arbeit finden.USP: Einzige Monographie zur Analyse von Pharmazeutika mit CE This book describes the current state of the art for the analysis of pharmaceuticals by capillary electrophoresis and contains several hundred references to specific applications and methods. The main purpose of the book is to present the application possibilities of CE an therefore tabulated application data are provided. Chapters of the book are devoted to providing details of individual application areas such as chiral analysis, determination of drug related impurities, determination of drug counter-ions, drug residue monitoring and main component assay. An introductory chapter provides theoretical background to CE an related techniques. A chapter is dedicated to capillary electrochromatography which highlights the importance this technique currently possesses. Successful regulatory acceptance of CE methods is also described. A comprehensive chapter covers method validation aspects. Other chapters include discrete areas such as the use of non-aqueous solvents, forensic applications of CE, the application of experimental designs, determination of drugs in biofluids, and the analysis of vitamins by CE.

Chemistry 2e
Chemistry 2e

Author: Paul Flowers

Publisher:

Published: 2019-02-14

Total Pages: 0

ISBN-13: 9781947172623

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Chemistry 2e is designed to meet the scope and sequence requirements of the two-semester general chemistry course. The textbook provides an important opportunity for students to learn the core concepts of chemistry and understand how those concepts apply to their lives and the world around them. The book also includes a number of innovative features, including interactive exercises and real-world applications, designed to enhance student learning. The second edition has been revised to incorporate clearer, more current, and more dynamic explanations, while maintaining the same organization as the first edition. Substantial improvements have been made in the figures, illustrations, and example exercises that support the text narrative. Changes made in Chemistry 2e are described in the preface to help instructors transition to the second edition.

Divorce and Family Mediation
Divorce and Family Mediation

Author: Jay Folberg

Publisher: Guilford Press

Published: 2004-05-12

Total Pages: 616

ISBN-13: 9781593850029

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Building on the success of their groundbreaking 1988 Divorce Mediation, Folberg et al. now present the latest state-of-the-art, comprehensive resource on family and divorce mediation. Paving the way for the field to establish its own distinct discipline and academic tradition, this authoritative volume offers chapters contributed by leading mediation researchers, trainers, and practitioners. Detailed are the theory behind mediation practice, the contemporary social and political context, and practical issues involved in mediating divorce and custody disputes with contemporary families. Authors also address intriguing questions about professional standards and where the field should go from here. A groundbreaking resource, this volume is indispensable for all mental health and legal professionals working with families in transition.