Discovery and In Vivo Characterization of Long Noncoding RNAs
Author: Stephen Constantine Liapis
Publisher:
Published: 2016
Total Pages:
ISBN-13:
DOWNLOAD EBOOKThe noncoding genome, or the portion of the genome that does not encode for proteins, encompasses >95% of the human genome. It has been found that the majority of disease-associated genetic variants identified by genome-wide association studies (GWAS) are located in this noncoding 95%, where they have the potential to affect regions that control transcription (promoters, enhancers) and noncoding RNAs that also can influence gene expression. The discovery of these alterations has already contributed to a better understanding of the etiology of human diseases and has begun to yield insight into the function of these noncoding loci I am interested in studying how the noncoding genome functions and contributes to human development and disease pathology, especially when it is considered that our understanding of human disease is almost entirely contained within the realm of the