Differentiation of Enantiomers II
Differentiation of Enantiomers II

Author: Volker Schurig

Publisher: Springer

Published: 2014-07-08

Total Pages: 354

ISBN-13: 3319037161

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Chiral Derivatizing Agents, Macrocycles, Metal Complexes and Liquid Crystals for Enantiomer Differentiation in NMR Spectroscopy: Thomas J. Wenzel. Chiral NMR Solvating Additives for Differentiation of Enantiomers: Gloria Uccello-Barretta and Federica Balzano. Chiral Sensor Devices for Differentiation of Enantiomers: Kyriaki Manoli, Maria Magliulo and Luisa Torsi. Enantiopure supramolecular cages: synthesis and chiral recognition properties: Thierry Brotin, Laure Guy, Alexandre Martinez, Jean-Pierre Dutasta. Interconversion of Stereochemically Labile Enantiomers (Enantiomerization) : Oliver Trapp. Anisotropy Spectra for Enantiomeric Differentiation of Biomolecular Building Blocks: A.C. Evans, C. Meinert, J.H. Bredehöft, C. Giri, N.C. Jones, S.V. Hoffmann, U.J. Meierhenrich. Self-disproportionation of Enantiomers of Enantiomerically Enriched Compounds: Alexander E. Sorochinsky and Vadim A. Soloshonok.

Differentiation of Enantiomers I
Differentiation of Enantiomers I

Author: Volker Schurig

Publisher: Springer

Published: 2013-12-16

Total Pages: 286

ISBN-13: 3319032399

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The series Topics in Current Chemistry presents critical reviews of the present and future trends in modern chemical research. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience. Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field.

Enantiomer Separation
Enantiomer Separation

Author: Fumio Toda

Publisher: Springer Science & Business Media

Published: 2005-01-27

Total Pages: 334

ISBN-13: 1402023367

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Enantiomer Separation is written by several experts working in modern enantiomer separation chemistry who understand the needs of the many scientific and engineering chemists who need a cost-efficient supply of optically active materials of high quality. This book contains the following modern practical methods of enantiomer separation: Inclusion complexation of a racemic compound with a chiral host compound, which gives chiral host-chiral guest inclusion compounds, from which the chiral guest can be obtained. When this separation is combined with distillation technique, for example, enantiomer separation can be accomplished by fractional distillation in the presence of a chiral host compound. This is a modern and "green" procedure of enantiomer separation. These separation methods are described in several chapters of the book. Biological separation methods and "green" methods are covered in two chapters. Enantiomer separation by chromatography on a column containing chiral solid phase is one of the most up-to-date and well known "green" methods of enantiomer separation. Two experts in chromatography have contributed to provide two very important chapters on this method of separation. Practical methods of enantiomer separation are important both in the research laboratory and in industry, especially in the pharmaceutical, fine chemical and electronic industries. Chemists and engineers, as well as students who are working in the field of chiral compounds in universities, institute and industry, will find this book an invaluable resource.

The Separation of Enantiomers by Capillary Electrophoresis
The Separation of Enantiomers by Capillary Electrophoresis

Author: Stephen Wren

Publisher: Springer Science & Business Media

Published: 2013-04-17

Total Pages: 96

ISBN-13: 3322831418

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This book gives a comprehensive overview on the principles of physical and mathematical modelling of enantiomer separation by CE. Method development strategies are shown and cyclodextrins as a popular group of chiral selectors as well as some other selectors used as buffer additives for enantiomer separation in free solution are described.

Stereo-Differentiating reactions
Stereo-Differentiating reactions

Author: Yoshiharu Izumi

Publisher: Elsevier

Published: 2012-12-02

Total Pages: 345

ISBN-13: 0323155030

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Stereo-Differentiating Reactions: The Nature of Asymmetric Reactions provides an introduction to asymmetric reactions. It brings together synthetic organic chemistry, stereochemistry, group theory, the theory of optical rotation, experimental methods, etc., all of which are basic to the study of stereo-differentiating reactions, to form a unified approach based on the new concept of "differentiation." The authors hope that the value of the new concept, which is rather more complex than conventional treatments of asymmetric reactions, will become clear in the present book. This new concept should be useful in many fields of study, not only the development of stereo-differentiating reactions, but also in the study of general reaction mechanisms in organic chemistry. The book contains nine chapters and begins with a historical background of studies on asymmetric reactions. This is followed by separate chapters on molecular symmetry and chirality; nomenclature for chirality, prochirality, and stereo-differentiating reactions; the mechanisms of stereo-differentiating reactions; methods for studying stereo-differentiating reactions; and the basic principle of optical activity.

Chiral Recognition in Separation Methods
Chiral Recognition in Separation Methods

Author: Alain Berthod

Publisher: Springer Science & Business Media

Published: 2010-06-16

Total Pages: 349

ISBN-13: 3642124453

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What drives a scientist to edit a book on a speci c scienti c subject such as chiral mechanisms in separation methods? Until December 2005, the journal Analytical Chemistry of the American Chemical Society (Washington, DC) had an A-page section that was dedicated to simple and clear presentations of the most recent te- niques or the state of the art in a particular eld or topic. The “A-page” section was prepared for a broad audience of chemists including industrial professionals, s- dents as well as academics looking for information outside their eld of expertise. 1 Daniel W. Armstrong, one of the editors of this journal and a twenty-year+ long friend, invited me to present my view on chiral recognition mechanisms in a simple and clear way in an “A-page” article. In 2006, the “A-page” section was maintained as the rst articles at the beginning of each rst bi-monthly issue but the pagination was no longer page distinguished from the regular research articles published by the journal. During the time between the invitation and the submission, the A-page section was integrated into the rest of the journal and the article appeared as (2006) Anal Chem (78):2093–2099.

Preparative Enantioselective Chromatography
Preparative Enantioselective Chromatography

Author: Geoffrey B. Cox

Publisher: John Wiley & Sons

Published: 2008-04-15

Total Pages: 344

ISBN-13: 1405144718

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The development of chiral liquid chromatography, facilitating thestraightforward separation of enantiomers, was a significantadvance in chromatography, leading to widespread application inanalytical chemistry. Application in preparative chromatography hasbeen less rapid, but with the development of single enantiomerpharmaceuticals its use is increasingly common in chemicalsynthesis at laboratory, pilot plant and even full productionscale. Brings non-experts up to speed quickly and comprehensively,facilitating the rapid development of effective separations ofenantiomeric mixtures on a range of process scales Presents case studies drawn from within the pharmaceuticalindustry to clearly illustrate the utility and value of preparativescale enantioselective chromatography in chemical research,development and production Key reference source and entry to the literature so the readerdoes not have to engage in expensive and time consuming literaturesearching