Diagnostic Assessment and Treatment of Peripheral Nerve Tumors
Diagnostic Assessment and Treatment of Peripheral Nerve Tumors

Author: Fernando Guedes

Publisher: Springer Nature

Published: 2021-08-24

Total Pages: 380

ISBN-13: 3030776336

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Tumors involving peripheral nerves may be extremely challenging lesions to diagnose and treat. In order to optimize their management, physicians should have a thorough knowledge of peripheral nerve anatomy and pathology (both gross and microscopic), as well as familiarity with microsurgical techniques and intraoperative neurophysiological recording. This compendium deals with all aspects of tumors affecting peripheral nerves, from diagnosis to treatment; the topics it addresses range from epidemiology, anatomy, physiology, pathology, and clinical diagnosis to electrophysiology, imaging, genetic/cytomolecular aspects. Surgical approaches, biopsies and resection of various benign, malignant and pseudo-tumoral lesions, plexus tumors (both brachial and lumbosacral), and adjunctive treatment modalities and pain-related issues are described in detail. The book is intended not only for neurosurgeons, hand surgeons, plastic and orthopedic surgeons new to the field, but also for seasoned specialists who wish to update their knowledge with new insights based on robust experimental and clinical material. In addition, it will be a helpful tool for general and oncological surgeons who are sometimes faced with the treatment of mass lesions that may be potential nerve tumors, and for all practitioners who are engaged in the arduous struggle to bring relief to patients affected by these lesions.

Enzinger and Weiss's Soft Tissue Tumors E-Book
Enzinger and Weiss's Soft Tissue Tumors E-Book

Author: John R. Goldblum

Publisher: Elsevier Health Sciences

Published: 2013-10-11

Total Pages: 1173

ISBN-13: 1455737631

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Enzinger and Weiss's Soft Tissue Tumors is your essential medical reference on the diagnosis of tumors of the skeletal muscles, connective tissue, fat, and related structures. No other source matches Enzinger and Weiss’s scope and depth of coverage in this complex and challenging area of surgical pathology, and no other text contains as much practical information on differential diagnosis. Microscopic findings are correlated with the latest developments in molecular biology, cytogenetics, and immunohistochemistry, providing you with a comprehensive and integrated approach to the evaluation of soft tissue specimens. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Compare what you see under the microscope to nearly 2,000 superb images that capture the appearance of a complete range of pathological entities and help you relate their characteristics to their specific classifications. Apply the latest knowledge on FNA biopsy, molecular biology, and cytogenetics. Make rapid and effective decisions with the aid of extensive algorithms, and access information at a glance with abundant tables and graphs. Take advantage of all of the essential clinical and prognostic data on soft tissue tumors that are necessary to formulate complete sign-out reports. Navigate through the book quickly thanks to summary outlines at the beginning of each chapter, a color-coded page design, and a consistent approach to every entity. Apply the latest advances in surgical pathology thanks to major updates on recently identified pathological entities such as soft tissue angiofibroma and CIC-related sarcomas; coverage of the newest molecular diagnostic techniques and immunohistochemical and molecular genetic features of soft tissue tumors; new chapters on GIST and soft tissue tumors showing melanocytic differentiation; and more. Effortlessly find the information you need with a chapter organization based on the newest surgical pathology concepts and classifications of soft tissue tumors.

Diagnosis, Management and Emerging Strategies for Chemotherapy-Induced Neuropathy
Diagnosis, Management and Emerging Strategies for Chemotherapy-Induced Neuropathy

Author: Maryam Lustberg

Publisher: Springer Nature

Published: 2021-10-07

Total Pages: 265

ISBN-13: 3030786633

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This book comprehensively examines chemotherapy-induced peripheral neuropathy (CIPN), a common dose-limiting condition that negatively affects both the quality of life of cancer patients and disease outcomes. CIPN remains a challenging area for both clinical care and research, as there are multiple unresolved issues. Written by leading international experts, the book discusses the natural history of CIPN, the latest predictors of toxicity, instruments for evaluating symptoms, and prevention/therapeutic strategies, as well as patients’ experiences of this common clinical syndrome. Lastly it highlights avenues for future research to enhance our understanding of CIPN. Providing essential information on the management of CIPN and the latest research in the field, this book is a valuable resource for researchers and healthcare providers working with patients with various malignant diseases.

Surgery of Peripheral Nerves
Surgery of Peripheral Nerves

Author: Rajiv Midha

Publisher: Thieme

Published: 2011-01-01

Total Pages: 308

ISBN-13: 1638533512

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A case-based guide to diagnosing and treating peripheral nerve disorders Surgery of Peripheral Nerves: A Case-Based Approach is a concise, single-volume reference for managing the entire spectrum of peripheral nerve pathologies, from brachial plexus injuries to lower extremity nerve entrapments. It features 57 cases that are grouped in sections by anatomic location of the problem to aid rapid reference to topics of interest, with one additional section that addresses the management of nerve tumors, painful nerve conditions, and other injuries and syndromes. Each chapter provides concise descriptions of case presentation, diagnosis, anatomy, characteristic clinicalpresentation, differential diagnosis, diagnostic tests, management options, and surgical treatment. Highlights: Case-based format thoroughly prepares the reader for managing various problems in the clinical setting Diagnostic guidelines and management strategies from leading experts in the field of peripheral nerve surgery enable clinicians to confidently handle each stage of patient care Pearls and Pitfalls at the end of each chapter highlight critical aspects of treatment and are ideal for at-a-glance review prior to surgery More than 150 illustrations demonstrate key concepts Suggested readings with brief summaries provide valuable reviews of the literature This problem-oriented textbook is ideal for clinicians, fellows, and residents in neurosurgery, orthopaedics, plastic surgery, and hand surgery. It also serves as an indispensable reference for specialists in physical medicine and rehabilitation, neurology, emergency medicine, pain management, and physical and occupational therapy.

Peripheral Nerve Disorders
Peripheral Nerve Disorders

Author: Kåre Fugleholm

Publisher: Elsevier Inc. Chapters

Published: 2013-08-17

Total Pages: 54

ISBN-13: 0128078766

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Surgical pathology of the peripheral nervous system includes traumatic injury, entrapment syndromes, and tumors. The recent significant advances in the understanding of the pathophysiology and cellular biology of peripheral nerve degeneration and regeneration has yet to be translated into improved surgical techniques and better outcome after peripheral nerve injury. Decision making in peripheral nerve surgery continues to be a complex challenge, where the mechanism of injury, repeated clinical evaluation, neuroradiological and neurophysiological examination, and detailed knowledge of the peripheral nervous system response to injury are prerequisite to obtain the best possible outcome. Surgery continues to be the primary treatment modality for peripheral nerve tumors and advances in adjuvant oncological treatment has improved outcome after malignant peripheral nerve tumors. The present chapter provides background knowledge of surgical peripheral nerve disease and some general and practical guidance toward its clinical management.

Musculoskeletal Diseases 2021-2024
Musculoskeletal Diseases 2021-2024

Author: Juerg Hodler

Publisher: Springer Nature

Published: 2021

Total Pages: 293

ISBN-13: 3030712818

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This open access book focuses on imaging of the musculoskeletal diseases. Over the last few years, there have been considerable advances in this area, driven by clinical as well as technological developments. The authors are all internationally renowned experts in their field. They are also excellent teachers, and provide didactically outstanding chapters. The book is disease-oriented and covers all relevant imaging modalities, with particular emphasis on magnetic resonance imaging. Important aspects of pediatric imaging are also included. IDKD books are completely re-written every four years. As a result, they offer a comprehensive review of the state of the art in imaging. The book is clearly structured with learning objectives, abstracts, subheadings, tables and take-home points, supported by design elements to help readers easily navigate through the text. As an IDKD book, it is particularly valuable for general radiologists, radiology residents, and interventional radiologists who want to update their diagnostic knowledge, and for clinicians interested in imaging as it relates to their specialty.

Peripheral Nerve Disorders
Peripheral Nerve Disorders

Author: Rosalie E. Ferner

Publisher: Elsevier Inc. Chapters

Published: 2013-08-17

Total Pages: 44

ISBN-13: 0128078847

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Neurofibromatosis 1 (NF1) is an inherited neurocutaneous disease that has a major impact on the nervous system, eye, skin, and bone. Individuals with NF1 have a predisposition to benign and malignant tumor formation and the hallmark lesion is the neurofibroma, a benign peripheral nerve sheath tumor. The gene for NF1 was cloned on chromosome 17q11.2 and neurofibromin, the NF1 protein, controls cell growth and proliferation by regulating the proto-oncogene Ras and cyclic adenosine monophosphate (AMP). Advances in molecular biology and mouse models of disease have enhanced our understanding of the pathogenesis of NF1 complications and facilitated targeted therapy. Progress has been made in developing robust clinical and radiological outcome measures and clinical trials are underway for children with learning difficulties and for individuals with symptomatic plexiform neurofibromas.

Peripheral Nerve Disorders
Peripheral Nerve Disorders

Author: Simon K.W. Lloyd

Publisher: Elsevier Inc. Chapters

Published: 2013-08-17

Total Pages: 33

ISBN-13: 0128078855

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Neurofibromatosis type 2 (NF2) is an autosomal dominant inherited tumor predisposition syndrome caused by mutations in the NF2 gene on chromosome 22. Affected individuals develop schwannomas typically involving both vestibular nerves leading to hearing loss and eventual deafness. Rehabilitation with brainstem implants and in some cases cochlear implants is improving this outcome. Schwannomas also occur on other cranial nerves, on spinal nerve roots and peripheral nerves, and intracutaneously as plaques. Cranial and spinal meningiomas and spinal ependymomas are other common tumors. Fifty to sixty percent of patients represent de novo mutations and as many as 33% of these are mosaic for the underlying disease causing mutation. Truncating mutations (nonsense, frameshift insertions/deletions) are the most frequent germline events and cause the most severe disease, whilst single and multiple exon deletions are common and are usually associated with milder NF2. Neurological deficits are a major feature of the condition and neurologists have a pivotal role in assigning symptoms to lesions and in managing neuropathies. NF2 represents a difficult management problem with most patients facing substantial morbidity and reduced life expectancy. Surgery remains the focus of current management although watchful waiting and occasionally radiation treatment have a role. We are seeing the advent of tailored drug therapies aimed at the genetic level and these are likely to provide huge improvements for this devastating, life-limiting condition.