This book describes advances in implantable neural stimulation technology to restore partial sight to people who are blind from retinal degnerative diseases such as age-related macular degeneration and retintis pigmentosa. Many scientific, engineering, and surgical challenges must be surmounted before widespread practical applications can be realized. The book summarizes the state of research and clinical practice in the field and reviews the current ideas and approaches of its leading researchers and practitioners.
This book presents and analyses the most recent research dedicated to restoring vision in individuals who are severely impaired or blind from retinal disease or injury. It is written by the leading groups worldwide who are at the forefront of developing artificial vision. The book begins by discussing the difficulties in comparing and interpreting functional results in the area of very low vision and the principal prospects and limitations of spatial resolution with artificial tools. Further on, chapters are included by researchers who stimulate the surface or the pigment epithelial side of the retina and by experts who work on stimulating the optic nerve, the lateral geniculate body and the superficial layers of the visual cortex. Artificial Vision: A Clinical Guide collates the most recent work of key artificial vision research groups to explain in a comparable and stringent order their varying approaches, the clinical or preclinical outcomes and their achievements during the last years. Senior ophthalmic fellows and academic practitioners will find this guide to be an indispensable resource for understanding the current status of artificial vision.
Jens Naumann, a typical energetic young man of 17 had just moved out of his parent's home in Northern British Columbia, moving into a railway camp as an employee with the British Columbia Railway. All goes well as Jens enjoys his new found freedom, treasuring his driver's license and its associated freedom of travel. Then on a wintry day in 1981, fate rears its ugly head and strikes him blind in his left eye. Jens quickly rearranges his life to accommodate his new found fear - that of losing his remaining eye now that the true vulnerability of his eyesight is revealed. As his life continues onwards despite the initial readjustment, he finds ultimate happiness in his new marriage to his young wife Lorri, and just when life stands at its threshold of paradise exploring fatherhood along with the beauty of travel and thrill, his worst nightmare becomes reality not once, but twice in the most bizarre series of unforeseen incidents of bad luck; as Jens is totally blinded with no foreseeable chance of seeing again according to the best medical experts. Jens tries his best to adjust to this unwanted situation, exploring conventional methods of rehabilitation to live with blindness, as well as using imaginative, totally unheard - of activities in order to pass his time in a hope of someday being able to see again despite all the odds stacked against him. Close to the turn of the century, Jens unexpectedly receives news of an American Medical Device Engineer, Dr. William H. Dobelle, inviting blind adults as patients for his newly developed artificial vision system designed to provide limited vision via visual cortex stimulation. Dr. Dobelle claims that his system has a good chance in functioning based on previous experimenting with volunteers, at the same time classifying the surgical procedure as minor. The system and its related components is complicated; consisting of not only the implants, but a series of "electrical sockets" protruding from the patients head to which an array of computer boxes and stimulator hardware is connected and worn by the patient. Jens is determined to be one of the patients, regardless of the remoteness of the chance of being one out of literally millions of blind people in the World possibly lining up to have this procedure in hopes of ending their blindness for once and for all. To his absolute surprise, Jens is accepted as the first patient for this procedure and slowly builds a relationship with Dr. Dobelle as Jens overcomes obvious barriers of raising enough money for the very expensive procedure, as well as fighting the challenges of relentless forces working against him for his involvement in the Dobelle vision project. Armed with preconceived ideas of how a research institute should be run, Jens travels overseas for the various stages of the procedure, only to find the most astonishing facts of what goes on in the heart of a renowned medical research institute. Not only is Jens looking at the workings of the Dobelle Institute from the view of a patient, but in short time Jens is hired by the firm as Patient Representative, providing further exploration yet on the inner most details concerning a research company and its treatment of the 15 additional implanted patients. Throughout the book, Jens describes the devastation, exhilaration, disappointment, elation, and confusion that attempts at sight recovery, medical intervention, media propaganda, and ethical boundaries conjure in the most illustrative intensity. The manner in which the book ends is most indescribable; one could view it as the final straw, the beginning of a new era, the curse of the unforgiven, the sadness of a crushing reality, the beginning of a good job left unfinished; or that of the birth of a new expert compelled to unleash the new found knowledge for the whole World to thrive. Just as many questions are answered, many more yet are opened and left so far undiscovered. Search for Paradise is ce
This Handbook serves as an authoritative reference book in the field of Neuroengineering. Neuroengineering is a very exciting field that is rapidly getting established as core subject matter for research and education. The Neuroengineering field has also produced an impressive array of industry products and clinical applications. It also serves as a reference book for graduate students, research scholars and teachers. Selected sections or a compendium of chapters may be used as “reference book” for a one or two semester graduate course in Biomedical Engineering. Some academicians will construct a “textbook” out of selected sections or chapters. The Handbook is also meant as a state-of-the-art volume for researchers. Due to its comprehensive coverage, researchers in one field covered by a certain section of the Handbook would find other sections valuable sources of cross-reference for information and fertilization of interdisciplinary ideas. Industry researchers as well as clinicians using neurotechnologies will find the Handbook a single source for foundation and state-of-the-art applications in the field of Neuroengineering. Regulatory agencies, entrepreneurs, investors and legal experts can use the Handbook as a reference for their professional work as well.
Signi?cant progress has been made in the development of neural prostheses for restoration of human functions and improvement of the quality of life. Biomedical engineers and neuroscientists around the world are working to improve the design and performance of existing devices and to develop novel devices for arti?cial vision, arti?cial limbs, and brain-machine interfaces. This book, Implantable Neural Prostheses 2: Techniques and Engineering Approaches, is part two of a two-volume sequence that describes state-of-the-art advances in techniques associated with implantable neural prosthetic devices. The techniques covered include biocompatibility and biostability, hermetic packaging, electrochemical techniques for neural stimulation applications, novel electrode materials and testing, thin-?lm ?exible microelectrode arrays, in situ char- terization of microelectrode arrays, chip-size thin-?lm device encapsulation, microchip-embedded capacitors and microelectronics for recording, stimulation, and wireless telemetry. The design process in the development of medical devices is also discussed. Advances in biomedical engineering, microfabrication technology, and neu- science have led to improved medical-device designs and novel functions. However, many challenges remain. This book focuses on the engineering approaches, R&D advances, and technical challenges of medical implants from an engineering p- spective. We are grateful to leading researchers from academic institutes, national laboratories, as well as design engineers and professionals from the medical device industry who have contributed to the book. Part one of this series covers designs of implantable neural prosthetic devices and their clinical applications.
Recent technological advances in the diagnosis of macular disorders have enhanced our understanding of these diseases. At the same time, advances in small-gauge vitrectomy instrumentation and techniques have improved the safety and efficiency of surgery, allowing macular conditions that would have otherwise resulted in blindness to be treated effectively, preserving patients’ sight. Macular surgery continues to evolve rapidly, thanks to exciting future technology trends. This book provides a detailed and up-to-date overview of the field. It begins with essential information on macular anatomy and pathophysiology, examination techniques, and surgical instrumentation. In turn, it discusses a broad range of disease processes, including macular holes, epiretinal membrane, vitreomacular traction and myopic maculopathy. The role and benefits of advanced vitrectomy techniques including submacular surgery, prosthetic vision, robotic surgery, and stem cell and gene therapy are addressed in detail. A review of perioperative care and potential complications rounds out the coverage.
Master simple to advanced biomaterials and structures with this essential text. Featuring topics ranging from bionanoengineered materials to bio-inspired structures for spacecraft and bio-inspired robots, and covering issues such as motility, sensing, control and morphology, this highly illustrated text walks the reader through key scientific and practical engineering principles, discussing properties, applications and design. Presenting case studies for the design of materials and structures at the nano, micro, meso and macro-scales, and written by some of the leading experts on the subject, this is the ideal introduction to this emerging field for students in engineering and science as well as researchers.
The Routledge Handbook of Visual Impairment examines current debates as well as cross-examining traditionally held beliefs around visual impairment. It provides a bridge between medical practice and social and cultural research drawing on authentic investigations. It is the intention of this Handbook to provide an opportunity to engage with academic researchers who wish to ensure a coherent and rigorous approach to research construction and reflection on visual impairment that is in collaboration with, but sometimes is beyond, the medical realm. This Handbook is divided into ten thematic areas in order to represent the wide range of debates and concepts within visual impairment. The ten themes include: cerebral visual impairment; education; sport and physical exercise; assistive technology; understanding the cultural aesthetics; socio-emotional and sexual aspects of visual impairment; orientation, mobility, habitation, and rehabilitation; recent advances in "eye" research and sensory substitution devices; ageing and adulthood. The 27 chapters that explore the social and cultural aspects of visual impairment can be taken and used in a variety of different ways in order to promote research and generate debate among practitioners and scholars who wish to use this resource to inform their practice in supporting and developing positive outcomes for all.
Over the last twenty years there has been an explosive growth in our understanding of the molecular, cellular, and anatomical changes that occur in the days and weeks following brain injury. It is now clear that training and exposure to certain environments can modify and shape neuronal plasticity in lower animals and humans. In humans, in particular, there are new ways of charting neuronal plasticity at the ensemble or regional level using functional neuroimaging techniques such as positron emission tomography and functional magnetic resonance imaging. Thus, the time seems right for transporting the laboratory results to the clinic so that experimental findings can be tested in the "field". This volume provides some impetus to moving the field of cognitive neuroscience a little further in its efforts to improve the lives of patients who have suffered a debilitating brain injury.
