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Author: Emiliano Ventura
Publisher:
Published: 2020
Total Pages:
ISBN-13:
DOWNLOAD EBOOKAuthor: Mario Thevis
Publisher: John Wiley & Sons
Published: 2010-12-13
Total Pages: 294
ISBN-13: 1118035143
DOWNLOAD EBOOKEnables you to detect, identify, and characterize hundreds of drugs that may be used by athletes Mass spectrometry has become essential to sports drug testing. This book examines both the principles of sports drug testing and the use of mass spectrometry techniques and mass spectral data to detect, identify, and characterize hundreds of known and unknown drugs that athletes may use to enhance their performance. The author provides a detailed overview of the mass spectrometry of numerous classes of therapeutics and agents, various analyzers to detect low- and high-molecular weight drugs, as well as techniques to discriminate between endogenously produced and synthetically derived compounds. Mass Spectrometry in Sports Drug Testing begins with a full chapter dedicated to the history of sports drug testing. Next, the book provides the principles and techniques needed to maximize the specificity and sensitivity of mass spectrometric assays, including: Detailed, step-by-step assays with sample preparation Discussion of both chromatographic separation and mass spectrometric analysis Characterization of analytes in order to unequivocally identify banned substances Mass spectrometric behavior of low- and high-molecular weight analytes Throughout the book, descriptive examples illustrate the principles, advantages, and limitations of different assays. Mass Spectrometry in Sports Drug Testing not only sets forth the role mass spectrometry plays in detecting drug use among athletes, it also adds new insights into the health and ethical issues of doping in sports.
Author: Mu Naushad
Publisher: CRC Press
Published: 2014-03-18
Total Pages: 464
ISBN-13: 1466591552
DOWNLOAD EBOOKThis book presents a unique collection of up-to-date UPLC-MS/MS (ultra performance liquid chromatography-tandem mass spectrometric) methods for the separation and quantitative determination of pesticides, capsaicinoids, heterocyclic amines, aflatoxin, perfluorochemicals, acrylamide, procyanidins and alkaloids, lactose content, phenolic compounds, vitamins, and aroma and flavor compounds in a wide variety of foods and food products. With contributions by experts in interdisciplinary fields, this reference offers practical information for readers in research and development, production, and routing analysis of foods and food products.
Author: Daniela Remane
Publisher:
Published: 2011
Total Pages:
ISBN-13:
DOWNLOAD EBOOKAuthor: Satish Y. Gabhe
Publisher: Anchor Academic Publishing (aap_verlag)
Published: 2014-08
Total Pages: 114
ISBN-13: 395489307X
DOWNLOAD EBOOKThis book details: 1. Development and validation of a HPTLC-densitometric method for concurrent estimation of metformin hydrochloride, pioglitazone hydrochloride and gliclazide in combined dosage form. 2. Development and validation of a HPTLC method for simultaneous estimation of moxifloxacin hydrochloride and dexamethasone sodium phosphate in combined pharmaceutical dosage form. 3. Development and validation of a RP-HPLC method for simultaneous estimation of ciprofloxacin hydrochloride and dexamethasone in combined dosage form, which is a better alternative to existing ones. The developed analytical methods are simple, selective, accurate, robust, and precise with shorter analysis time for the analysis of drug/s in combined pharmaceutical dosage forms. All the developed HPTLC and HPLC methods have been validated as per ICH Q2 (R1) guideline. Developed analytical methods could boost analytical researchers to work more efficiently in the field of analytical method development and validation of Pharmaceutical dosage forms.
Author: Michael E. Swartz
Publisher: CRC Press
Published: 2018-10-03
Total Pages: 95
ISBN-13: 1482229773
DOWNLOAD EBOOKDescribes analytical methods development, optimization and validation, and provides examples of successful methods development and validation in high-performance liquid chromatography (HPLC) areas. The text presents an overview of Food and Drug Administration (FDA)/International Conference on Harmonization (ICH) regulatory guidelines, compliance with validation requirements for regulatory agencies, and methods validation criteria stipulated by the US Pharmacopia, FDA and ICH.
Author: Rebecca Wagner
Publisher:
Published: 2018
Total Pages: 10
ISBN-13:
DOWNLOAD EBOOKAuthor: Julia Claire McLouth
Publisher:
Published: 2013
Total Pages: 66
ISBN-13:
DOWNLOAD EBOOKPain management is a growing field of medical practice in the United States. In pain management practices, urine drug testing has emerged as the preferred method for medication compliance monitoring. A pain management clinic built its own drug testing laboratory, using a liquid chromatography tandem mass spectrometry testing method developed by a reference laboratory. Before accepting patient samples, the pain management laboratory validated the method to confirm its reliability. Validation included confirmation of, among other things, the accuracy, precision, and trueness of the method, the carryover on the instrument, and the stability of the samples. Once validated, the beta-glucuronidase hydrolysis described in the method was optimized for morphine conversion from morphine-3-glucuronide. Optimization experiments focused on the incubation time, incubation temperature, enzyme starting concentration and hydrolysis solution pH used for the hydrolysis reaction described in the method. Using analysis of variance and Dunnett's multiple comparisons test, the hydrolysis reaction was confirmed to produce optimum morphine conversion.
Author: Steen Honoré Hansen
Publisher: John Wiley & Sons
Published: 2015-07-20
Total Pages: 332
ISBN-13: 1118716825
DOWNLOAD EBOOKBioanalysis of Pharmaceuticals: Sample Preparation, Separation Techniques and Mass Spectrometry is the first student textbook on the separation science and mass spectrometry of pharmaceuticals present in biological fluids with an educational presentation of the principles, concepts and applications. It discusses the chemical structures and properties of low- and high-molecular drug substances; the different types of biological samples and fluids that are used; how to prepare the samples by extraction, and how to perform the appropriate analytical measurements by chromatographic and mass spectrometric methods. Bioanalysis of Pharmaceuticals: Sample Preparation, Separation Techniques and Mass Spectrometry: Is an introductory student textbook discussing the different principles and concepts clearly and comprehensively, with many relevant and educational examples Focuses on substances that are administered as human drugs, including low-molecular drug substances, peptides, and proteins Presents both the basic principles that are regularly taught in universities, along with the practical use of bioanalysis as carried out by researchers in the pharmaceutical industry and in hospital laboratories Is aimed at undergraduate students, scientists, technicians and researchers in industry working in the areas of pharmaceutical analyses, biopharmaceutical analyses, biological and life sciences The book includes multiple examples to illustrate the theory and application, with many practical aspects including calculations, thus helping the student to learn how to convert the data recorded by instruments into the real concentration of the drug substances within the biological sample.
Author: Mario Thevis
Publisher: Wiley
Published: 2010-08-02
Total Pages: 360
ISBN-13: 9780470413272
DOWNLOAD EBOOKEnables you to detect, identify, and characterize hundreds of drugs that may be used by athletes Mass spectrometry has become essential to sports drug testing. This book examines both the principles of sports drug testing and the use of mass spectrometry techniques and mass spectral data to detect, identify, and characterize hundreds of known and unknown drugs that athletes may use to enhance their performance. The author provides a detailed overview of the mass spectrometry of numerous classes of therapeutics and agents, various analyzers to detect low- and high-molecular weight drugs, as well as techniques to discriminate between endogenously produced and synthetically derived compounds. Mass Spectrometry in Sports Drug Testing begins with a full chapter dedicated to the history of sports drug testing. Next, the book provides the principles and techniques needed to maximize the specificity and sensitivity of mass spectrometric assays, including: Detailed, step-by-step assays with sample preparation Discussion of both chromatographic separation and mass spectrometric analysis Characterization of analytes in order to unequivocally identify banned substances Mass spectrometric behavior of low- and high-molecular weight analytes Throughout the book, descriptive examples illustrate the principles, advantages, and limitations of different assays. Mass Spectrometry in Sports Drug Testing not only sets forth the role mass spectrometry plays in detecting drug use among athletes, it also adds new insights into the health and ethical issues of doping in sports.
