Degeneration and Regeneration in the Nervous System
Degeneration and Regeneration in the Nervous System

Author: Norman Saunders

Publisher: CRC Press

Published: 2003-09-02

Total Pages: 354

ISBN-13: 0203304489

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Degeneration and Regeneration in the Nervous System brings together an international team of contributors to produce a series of critical reviews appraising key papers in the field. The pace of research on brain and spinal cord injury quickened considerably in the last ten years and there is much that is new and important that is covered in this book. However, there is still a long way to go before our knowledge will explain fully why the central nervous system has such a limited capacity for regeneration, and before experimental solutions can be applied to the patient. With emphasis on actual and therapeutic importance of the work reviewed, Degeneration and Regeneration in the Nervous System is a useful overview for graduate students, their teachers and researchers working in this field.

Cajal's Degeneration and Regeneration of the Nervous System
Cajal's Degeneration and Regeneration of the Nervous System

Author: Santiago Ramón y Cajal

Publisher: History of Neuroscience

Published: 1991

Total Pages: 977

ISBN-13: 0195065166

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This book is a reprint of an English translation of Cajal's original work, with abundant notes and commentaries by the editor. This text describes Cajal's fundamental contributions to neuroscience, which continue to be important today. It accurately details Cajal's ideas and data, and providesreaders with the opportunity to learn what Cajal thought about his research career and the significance of his observations. Excerpts from Tello's memorial lectures also provide a contemporary view of Cajal's work.

Degeneration and Regeneration in the Nervous System
Degeneration and Regeneration in the Nervous System

Author: Norman Saunders

Publisher: CRC Press

Published: 2000-01-13

Total Pages: 354

ISBN-13: 1482284073

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Degeneration and Regeneration in the Nervous System brings together an international team of contributors to produce a series of critical reviews appraising key papers in the field. The pace of research on brain and spinal cord injury quickened considerably in the last ten years and there is much that is new and important that is covered in this bo

Neuronal Degeneration and Regeneration: From Basic Mechanisms to Prospects for Therapy
Neuronal Degeneration and Regeneration: From Basic Mechanisms to Prospects for Therapy

Author: Fred W. Leeuwen

Publisher: Elsevier

Published: 1998-11-09

Total Pages: 560

ISBN-13:

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A collection of 35 papers generated by an international summer school held in Amsterdam during August 1997. Some constitute an overview of the basic research on nerve cell death (apoptosis and necrosis), neuronal survival, and neurite outgrowth and guidance, with special attention to the role of neurotrophins, their receptor tyrosine kinases, and cell-adhesion molecules in the development and regeneration of the nervous system. Others look at research involving human neurodegenerative diseases, emerging treatment strategies, and recent developments in the understanding of pathophysiological mechanisms underlying them. Several focus on new cell and gene therapies such as implanting genetically modified cells, direct gene transfer with viral vectors, and the first clinical trials with encapsulated genetically modified cells in patients suffering from anyotrophic lateral sclerosis. Annotation copyrighted by Book News, Inc., Portland, OR.

From Development to Degeneration and Regeneration of the Nervous System
From Development to Degeneration and Regeneration of the Nervous System

Author: Charles E. Ribak

Publisher: Oxford University Press

Published: 2009

Total Pages: 404

ISBN-13: 0195369009

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This book provides current information about the three areas mentioned in the title: Neuronal Migration and Development, Degenerative Brain Diseases, and Neural Plasticity and Regeneration. The chapters about brain development examine the cellular and molecular mechanisms by which neurons are generated from the ventricular zone in the forebrain and migrate to their destinations in the cerebral cortext. This description of cortical development also includes a discussions of the Cajal-Retzius cell. Another chapter provides insight about the development of another forebrain region, the hypothalamus. The remaining chapters of this section examine the clinical relevance of brain development in certain disease states in humans: neural tube defects and the normal and abnormal development of human electroencephalographic recordings during the first year of age.The second section on degenerative disorders of the brain begins wtih details about the dopaminergic neurons in the substantia niger and their loss in Parkinson's disease. Two subsequent chapters describe changes in brain aging, including changes in the numbers of myelinated axons. Other chapters in this section describe important cellular and molecular changes found in Alzheimer's disease and human epilepsy. Together, these chapters summarize much of our current knowledge about the major molecular and cellular changes found in several degenerative diseases of the brain.The last section addresses the issues of brain plasticity and regeneration in the adult brain and begins with a chapter on how the brain's own stem cells provide newly generated neurons to the hippocampal dentate gyrus and how these neurons become integrated into neural circuitry. The following two chapters examine some of the neuroplastic changes that take place in motor and sensory cortices of awake behaving primates. The concluding two chapters address the issue of regeneration in the injured spinal cord and the factors that may contribute to its success.

Nerve, Organ, and Tissue Regeneration: Research Perspectives
Nerve, Organ, and Tissue Regeneration: Research Perspectives

Author: Fredrick Seil

Publisher: Elsevier

Published: 2012-12-02

Total Pages: 499

ISBN-13: 0323148069

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Nerve, Organ, and Tissue Regeneration: Research Perspectives presents the proceedings of a symposium held in Harpers Ferry, West Virginia, on September 21–24, 1982. This book explores the neural and nonneural areas of regeneration, with emphasis on the nervous system. Organized into six parts encompassing 22 chapters, this compilation of papers examines the commitment of the Veterans Administration to deal with the clinical problem of spinal cord injury by establishing 19spinal cord injury treatment and rehabilitation centers throughout the United States. This book then discusses the characteristics of the neuronal response to axon injury, which vary from cellular hypertrophy and heightened metabolism to cell death. Other chapters consider the three phases of axonal regeneration, including sprout formation, elongation, and maturation. The final chapter deals with the structural and functional alterations that developed when the length of the mammalian intestine is shortened by excision or by-pass of a long segment. This book is a valuable resource for biologists, orthopedic surgeons, and neuroscientists.