Cycloadditions in Bioorthogonal Chemistry
Cycloadditions in Bioorthogonal Chemistry

Author: Milan Vrabel

Publisher: Springer

Published: 2016-05-28

Total Pages: 159

ISBN-13: 3319296868

DOWNLOAD EBOOK

The series Topics in Current Chemistry Collections presents critical reviews from the journal Topics in Current Chemistry organized in topical volumes. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience. Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field.

Cycloadditions in Bioorthogonal Chemistry
Cycloadditions in Bioorthogonal Chemistry

Author: David Phillips

Publisher: Createspace Independent Publishing Platform

Published: 2017-03-08

Total Pages: 300

ISBN-13: 9781979607919

DOWNLOAD EBOOK

Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field.The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience.

Cycloadditions in Bioorthogonal Chemistry
Cycloadditions in Bioorthogonal Chemistry

Author: John Paquette

Publisher: Createspace Independent Publishing Platform

Published: 2017-03-14

Total Pages: 300

ISBN-13: 9781981878024

DOWNLOAD EBOOK

The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field.Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed.

Modern Applications of Cycloaddition Chemistry
Modern Applications of Cycloaddition Chemistry

Author: Paolo Quadrelli

Publisher: Elsevier

Published: 2019-03-20

Total Pages: 354

ISBN-13: 0128152745

DOWNLOAD EBOOK

Modern Applications of Cycloaddition Chemistry examines this area of organic chemistry, with special attention paid to cycloadditions in synthetic and mechanistic applications in modern organic chemistry. While many books dedicated to cycloaddition reactions deal with the synthesis of heterocycles, general applications, specific applications in natural product synthesis, and the use of a class of organic compounds, this work sheds new light on pericyclic reactions by demonstrating how these valuable tools elegantly solve synthetic and mechanistic problems. The work examines how pericyclic reactions have been extensively applied to different chemistry areas, such as chemical biology, biological processes, catalyzed cycloaddition reactions, and more. This work will be useful for organic chemists who deal with organic chemistry, medicinal chemistry, agrochemistry and material chemistry. - Provides details on the synthesis of antiviral and anticancer compounds, marking the key role of unconventional catalyzed cycloaddition reactions for preparing new derivatives in a unique reaction pathway that is scalable in industrial processes - Contains the most up-to-date review of the use of pericyclic reactions in drug delivery - Includes the enzyme-catalyzed processes involving cycloaddition reactions for different targets, demonstrating that cycloaddition is more common in nature than expected - Features new applications for cycloadditions in material chemistry and provides a general view of the most recent results in the area

Cycloaddition Reactions in Organic Synthesis
Cycloaddition Reactions in Organic Synthesis

Author: Shu Kobayashi

Publisher: John Wiley & Sons

Published: 2002

Total Pages: 354

ISBN-13: 9783527301591

DOWNLOAD EBOOK

During the miners' strike in the 1980s, a worker is killed in the striking coalfields of Wales. Some months later, a government minister thought to be connected with the death is also shot. Lewis Redfern—once a radical but now a political analyst and journalist—pursues the sniper, a lonely hunt that leads him through an imbroglio of civil service leaks to a secret organization: a source of insurrection far more powerful than anyone could have suspected known as the Volunteers. In this fast-paced narrative of espionage and intrigue, Redfern, through his obsessive pursuit of justice, finally encounters the truth about himself as the novel discusses the conflict between moral choice and political loyalty.

Bioorthogonal Reagents
Bioorthogonal Reagents

Author: Nile S. Abularrage

Publisher:

Published: 2023

Total Pages: 0

ISBN-13:

DOWNLOAD EBOOK

The development of reactions that fit the stringent criteria for click chemistry and bioorthogonal chemistry has enabled discoveries and applications in fields ranging from materials science to chemical biology. These reactions must proceed rapidly and selectively under mild conditions. This enables the chemistry to be performed in complex systems without perturbing the normal function of the system. The prototypical bioorthogonal reactions are the copper(I) catalyzed azide-alkyne cycloaddition (CuAAC), the strain-promoted azide-alkyne cycloaddtion (SPAAC), and the tetrazine ligation. This thesis focuses on the development of new bioorthogonal reactions and reagents. In part 1, 5-membered cyclic Diels-Alder dienes are studied. This study ranges from the development of 4H-pyrazoles as bioorthogonal reagents to an exploration of the physical organic chemistry of 5-membered cyclic dienes that accelerate or impede their reactivity in Diels-Alder reactions. I show that 4H-pyrazoles can react rapidly as Diels-Alder dienes upon the induction of hyperconjugative antiaromaticity and predistortion. These dienes can also be stabilized to biological nucleophiles allowing their use in biological systems. In part 2, a new cyclooctyne is developed for SPAAC. This cyclooctyne, ABC, is activated by increased strain and electronic activation, and it reacts rapidly with azides and diazo compounds. This reactivity is a result of noncovalent interactions between the dipole and dipolarophile in the transition state; an n-->[pi]* interaction or a hydrogen bond. In addition to its fast reactivity, ABC can be prepared in three steps, and this work introduces a new synthetic route for the cyclooctyne scaffold.

Bioconjugate Techniques
Bioconjugate Techniques

Author: Greg T. Hermanson

Publisher: Academic Press

Published: 2010-07-26

Total Pages: 1233

ISBN-13: 0080568726

DOWNLOAD EBOOK

Bioconjugate Techniques, 2nd Edition, is the essential guide to the modification and cross linking of biomolecules for use in research, diagnostics, and therapeutics. It provides highly detailed information on the chemistry, reagent systems, and practical applications for creating labeled or conjugate molecules. It also describes dozens of reactions with details on hundreds of commercially available reagents and the use of these reagents for modifying or cross linking peptides and proteins, sugars and polysaccharides, nucleic acids and oligonucleotides, lipids, and synthetic polymers. A one-stop source for proven methods and protocols for synthesizing bioconjugates in the lab Step-by-step presentation makes the book an ideal source for researchers who are less familiar with the synthesis of bioconjugates More than 600 figures that visually describe the complex reactions associated with the synthesis of bioconjugates Includes entirely new chapters on the latest areas in the field of bioconjugation as follows: Microparticles and nanoparticlesSilane coupling agentsDendrimers and dendronsChemoselective ligationQuantum dotsLanthanide chelatesCyanine dyesDiscrete PEG compoundsBuckyballs,fullerenes, and carbon nanotubesMass tags and isotope tagsBioconjugation in the study of protein interactions

Handbook of In Vivo Chemistry in Mice
Handbook of In Vivo Chemistry in Mice

Author: Katsunori Tanaka

Publisher: John Wiley & Sons

Published: 2020-04-27

Total Pages: 560

ISBN-13: 3527344322

DOWNLOAD EBOOK

Provides timely, comprehensive coverage of in vivo chemical reactions within live animals This handbook summarizes the interdisciplinary expertise of both chemists and biologists performing in vivo chemical reactions within live animals. By comparing and contrasting currently available chemical and biological techniques, it serves not just as a collection of the pioneering work done in animal-based studies, but also as a technical guide to help readers decide which tools are suitable and best for their experimental needs. The Handbook of In Vivo Chemistry in Mice: From Lab to Living System introduces readers to general information about live animal experiments and detection methods commonly used for these animal models. It focuses on chemistry-based techniques to develop selective in vivo targeting methodologies, as well as strategies for in vivo chemistry and drug release. Topics include: currently available mouse models; biocompatible fluorophores; radionuclides for radiodiagnosis/radiotherapy; live animal imaging techniques such as positron emission tomography (PET) imaging; magnetic resonance imaging (MRI); ultrasound imaging; hybrid imaging; biocompatible chemical reactions; ligand-directed nucleophilic substitution chemistry; biorthogonal prodrug release strategies; and various selective targeting strategies for live animals. -Completely covers current techniques of in vivo chemistry performed in live animals -Describes general information about commonly used live animal experiments and detection methods -Focuses on chemistry-based techniques to develop selective in vivo targeting methodologies, as well as strategies for in vivo chemistry and drug release -Places emphasis on material properties required for the development of appropriate compounds to be used for imaging and therapeutic purposes in preclinical applications Handbook of In Vivo Chemistry in Mice: From Lab to Living System will be of great interest to pharmaceutical chemists, life scientists, and organic chemists. It will also appeal to those working in the pharmaceutical and biotechnology industries.

Chemoselective and Bioorthogonal Ligation Reactions
Chemoselective and Bioorthogonal Ligation Reactions

Author: W. Russ Algar

Publisher: John Wiley & Sons

Published: 2017-03-17

Total Pages: 923

ISBN-13: 352768347X

DOWNLOAD EBOOK

This timely, one-stop reference is the first on an emerging and interdisciplinary topic. Covering both established and recently developed ligation chemistries, the book is divided into two didactic parts: a section that focuses on the details of bioorthogonal and chemoselective ligation reactions at the level of fundamental organic chemistry, and a section that focuses on applications, particularly in the areas of chemical biology, biomaterials, and bioanalysis, highlighting the capabilities and benefits of the ligation reactions. With chapters authored by outstanding scientists who range from trailblazers in the field to young and emerging leaders, this book on a highly interdisciplinary topic will be of great interest for biochemists, biologists, materials scientists, pharmaceutical chemists, organic chemists, and many others.

Chemical Protein Synthesis
Chemical Protein Synthesis

Author: Xuechen Li

Publisher: Humana

Published: 2022-06-29

Total Pages: 0

ISBN-13: 9781071624883

DOWNLOAD EBOOK

This volume provides updated protocols for chemical protein synthesis. Chapters guide readers through development methods, strategies, and applications of protein chemical synthesis. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Chemical Protein Synthesis aims to be a useful and practical guide to new researchers and experts looking to expand their knowledge.