Crosstalk between Peripheral and Local Immune Response in the Pathophysiology of Stroke and Neurodegeneration Diseases, Volume II
Crosstalk between Peripheral and Local Immune Response in the Pathophysiology of Stroke and Neurodegeneration Diseases, Volume II

Author: Yuanjian Fang

Publisher: Frontiers Media SA

Published: 2024-03-06

Total Pages: 147

ISBN-13: 2832545750

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Accumulating evidence reveals both local and peripheral immune systems participated in the pathophysiology changes of acute and chronic neurological diseases. Immune cell activation facilitates inflammatory response in neurological diseases such as stroke, Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis. The immune response initiated by brain local cells (microglia and astrocytes) and peripheral blood cells (monocytes/macrophages, neutrophil, T cells, B cells), are now commonly thought to contribute “double-edged sword” effects to the progression of neurological diseases, which not only promoting repair and recovery, but also accelerating brain injury. Meanwhile, local and peripheral immune responses have complex crosstalk in the development of post-stroke injury and neurodegeneration disease.

Neuroinflammation in Stroke
Neuroinflammation in Stroke

Author: Ulrich Dirnagl

Publisher: Springer Science & Business Media

Published: 2013-04-17

Total Pages: 248

ISBN-13: 3662054264

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The successful treatment of acute stroke remains one of the major challenges in clinical medicine. Over the last decades, the understanding of stroke pathophysiology has greatly improved, while the therapeutic options in stroke therapy remain very limited. Today, hyperacute mechanisms of damage, such as excitotoxicity, can be discriminated from delayed ones, such as inflammation and apoptosis. Targeting of inflammation has already been successfully applied in various stroke models, but translation into a clinically efficacious strategy has not been achieved so far. In this book, leading experts in basic cerebrovascular research as well as stroke treatment review the current evidence for and against an important role for inflammation in stroke, and explore the potential of treating or modulating inflammation in stroke therapy.

Clinical Immunology
Clinical Immunology

Author: Robert R. Rich

Publisher: Mosby Incorporated

Published: 2008

Total Pages: 1578

ISBN-13: 9780323044042

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Offers answers to challenges in clinical immunology. This book contains immunology knowledge and includes a companion web site to give you two ways to find the answers you need.

Leucine-Rich Repeat Kinase 2 (LRRK2)
Leucine-Rich Repeat Kinase 2 (LRRK2)

Author: Hardy J. Rideout

Publisher: Springer

Published: 2017-03-28

Total Pages: 280

ISBN-13: 3319499696

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This is the first book to assemble the leading researchers in the field of LRRK2 biology and neurology and provide a snapshot of the current state of knowledge, encompassing all major aspects of its function and dysfunction. The contributors are experts in cell biology and physiology, neurobiology, and medicinal chemistry, bringing a multidisciplinary perspective on the gene and its role in disease. The book covers the identification of LRRK2 as a major contributor to the pathogenesis of Parkinson's Disease. It also discusses the current state of the field after a decade of research, putative normal physiological roles of LRRK2, and the various pathways that have been identified in the search for the mechanism(s) of its induction of neurodegeneration.

Neuroimmune Diseases
Neuroimmune Diseases

Author: Hiroshi Mitoma

Publisher: Springer

Published: 2019-08-13

Total Pages: 822

ISBN-13: 3030195155

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A translational overview of neuroimmune diseases for neuroscientists and clinicians that clarifies the pathological mechanisms underlying neuroimmune diseases and builds a comprehensive bridge between the latest research findings and their clinical implications in daily practice. The material is presented in two steps. The first section comprises a review of the pathogenic actions of immune cells in brain diseases. Here the authors discuss the mechanisms through which immune cells disrupt the functions of nerve cells. The second section explores the ways in which the brain becomes dysfunctional due to impaired nerve cell function. Based on pathogenesis, diagnostic and therapeutic strategies are discussed for each clinical category. The book will be invaluable for use in clinical practice of neuroimmune diseases

Textbook of Stroke Medicine
Textbook of Stroke Medicine

Author: Michael Brainin

Publisher: Cambridge University Press

Published: 2014-09-11

Total Pages: 425

ISBN-13: 1107047498

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Fully revised throughout, the new edition of this concise textbook is aimed at doctors preparing to specialize in stroke care.