Controversies in Pediatric and Adolescent Hematology
Controversies in Pediatric and Adolescent Hematology

Author: A.E. Thomas

Publisher: Karger Medical and Scientific Publishers

Published: 2013-11-29

Total Pages: 188

ISBN-13: 3318024236

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Hematological disorders in children and adolescents pose a wide range of management challenges and treatment dilemmas. In this book an internationally acclaimed panel of authors, each chosen for expertise in their field, have produced a state-of-the-art collection of review articles focusing on the very latest advances and controversies in the management of pediatric and adolescent hematological problems. The whole range of benign and malignant, congenital and acquired, acute and chronic conditions is discussed in detail. Individual chapters cover hematologic problems on the pediatric intensive care unit, treatments for iron deficiency and ITP; advances in stem cell transplantation, gene therapy, novel pharmaceutics and molecular diagnostics, as well as transition from child to adult are also explored. Providing an up-to-date look at both specific hematologic disorders in the pediatric and adolescent population and also hematologic problems that arise in association with systemic disease, this book is essential reading not only for pediatric and adult hematologists but also for pediatricians, pediatric or hematologic specialist nurse practitioners and pediatric pharmacologists.

Metabolic Syndrome and Obesity in Childhood and Adolescence
Metabolic Syndrome and Obesity in Childhood and Adolescence

Author: W. Kiess

Publisher: Karger Medical and Scientific Publishers

Published: 2015-01-27

Total Pages: 212

ISBN-13: 3318027995

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Despite the fact that the prevalence of obesity in early childhood has been stable and is no longer increasing in many developed and industrialized countries, the incidence of both obesity and full-blown metabolic syndrome in children and adolescents is still very high. Obesity is a major disease burden in all societies and needs to be prevented early in life. New approaches are eagerly sought and absolutely necessary. This book presents a comprehensive and state-of-the-art summary of current and new knowledge in this critical field. Crucial issues such as nutrition and genetics are described in detail. In addition, new ideas such as e-health and the consequences of urban living conditions are explored. Last but not least, modern treatment concepts and prevention even at an early age are competently discussed. Offering a valuable update on new developments in obesity research and the treatment in children and adolescents, this book is essential reading for all pediatricians and health-care professionals who look after young patients on a regular basis.

Neonatal Pharmacology and Nutrition Update
Neonatal Pharmacology and Nutrition Update

Author: F.B. Mimouni

Publisher: Karger Medical and Scientific Publishers

Published: 2014-11-17

Total Pages: 138

ISBN-13: 3318027367

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In order to provide safe and effective drug therapy to neonates, it is necessary to know about and understand the impact their development has on the pharmacokinetics and pharmacodynamics of drugs. The fact that children are different and neonates very different from adults means that, in neonates, it would be unwise to dose medications by scaling down adult doses proportionately, simply attempting to match their smaller weight and/or body surface area. When one makes decisions about neonatal drug therapy, one must not only take into consideration the available data but also critically assess and interpret this information within the context of fetal development and maturational processes as well as within the context of diseases that might affect a drug’s biodisposition. This book includes the latest information on the regulation and scientific basis of drug development and also provides a rationale for formula development for preterm infants. It offers guidance on how to translate pharmacokinetic data into dosing recommendations and also covers legal and regulatory issues relating to neonatal pharmacotherapy.

Childhood Cancer
Childhood Cancer

Author: Adolf E. Christ

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 305

ISBN-13: 1468472666

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The past decade has brought extraordinary gains in the outlook for children stricken with cancer. Though cancer remains a leading cause of death for children and young adults, more victims of child hood cancer today will survive than will die. The therapeutic advances and the optimism they instill have prompted researchers and clinicians to analyze the impact of cancer upon young patients and their famil,ies and to devise more effective intervention strategies. Hope and survival, juxtaposed with the continuing high mortality associated with certain forms of the illness, add new challenges to management of the psychosocial aspects of cancer. To respond to these challenges we need research as rigorous as that which continues to make inroads in treating the physical illness. This specific concern for the needs of children suffering from cancer and their families has paralleled an increasing sensitivity on the part of the medical community and the public at large to the limitations of specialized, high technology health care practices.

Progressive Neuroblastoma
Progressive Neuroblastoma

Author: H. Christiansen

Publisher: Karger Medical and Scientific Publishers

Published: 2015-09-28

Total Pages: 202

ISBN-13: 3318054976

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Neuroblastoma is a tumor derived from the sympathetic nervous system. It is the most common extracranial solid tumor occurring in children and exhibits a marked variability in outcome when the disease is categorized by clinical (e.g. age or stage) and biologic characteristics. This book gives an introduction into the clinical features of progressive neuroblastoma and focuses on molecular-targeted therapies and immunotherapies of this disease. It has become increasingly clear that MYCN (v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog) holds a key position in neuroblastic transformation and gene expression in normal and transformed cells. In the 14 chapters important topics such as genomic alterations in neuroblastoma and strategies for indirect molecular targeting of MYCN are discussed. Two chapters, for example, review apoptotic pathways and proapoptotic molecular targets in neuroblastoma, one focusing on the p53 pathway and the extrinsic and intrinsic pathways of apoptosis. Other chapters cover topics related to immunology in neuroblastoma, such as immune regulation in neuroblastoma, immunotherapy related to passive and active vaccination approaches and additional immunotherapy in the treatment of progressive disease. This volume will be essential reading for all clinicians and basic researchers who are involved in delivering health care to patients with progressive neuroblastoma.

Issues in Pediatric and Adolescent Medicine Research and Practice: 2011 Edition
Issues in Pediatric and Adolescent Medicine Research and Practice: 2011 Edition

Author:

Publisher: ScholarlyEditions

Published: 2012-01-09

Total Pages: 6537

ISBN-13: 1464963401

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Issues in Pediatric and Adolescent Medicine Research and Practice: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Pediatric and Adolescent Medicine Research and Practice. The editors have built Issues in Pediatric and Adolescent Medicine Research and Practice: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Pediatric and Adolescent Medicine Research and Practice in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Pediatric and Adolescent Medicine Research and Practice: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Pediatric Psycho-oncology
Pediatric Psycho-oncology

Author: Lori Wiener

Publisher: Oxford University Press, USA

Published: 2015

Total Pages: 433

ISBN-13: 0199335117

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Pediatric Psycho-Oncology is a comprehensive handbook that provides best practice models for the management of psychological, cognitive, and social outcomes of adolescents living with cancer and their families. Chapters cover a wide range of topics including psychological aspects of particular pediatric cancers and their treatments, how to talk to a child and family at critical times during the disease course, genetic testing, individual, family, educational, psychological and psychiatric interventions, and caring for international patients . Each chapter highlights the necessity of embracing an interdisciplinary approach to ensure that each child has the best options for living with cancer and, when cure is not possible, that death occurs with as much dignity as possible for the child and family. An extensive resource section is appended to provide information on written, online, video, community, national and international services and programs. This book features contributions from experts designed to help clinicians review, anticipate and respond to emotional issues that often arise in the context of treating pediatric cancer patients. Numerous cross-references and succinct tables and figures make this concise reference easy to use. Pediatric Psycho-Oncology is an ideal resource for helping pediatric oncologists and nurses recognize when it may be best to refer patients to their mental health colleagues and for those who are establishing pediatric oncology services or adding psychosocial components to existing clinics.