Controversies in Clinical Thyroidology
Controversies in Clinical Thyroidology

Author: J. I. Hamburger

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 315

ISBN-13: 1461259169

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"Man's natural instinct, in fact, is never toward what is sound and true. It is toward what is specious and false . . . The ideas that conquer the race most rapidly and arouse the wildest enthusiasm and are held most tenaciously are precisely the ideas that are most insane. This has been true since the first 'advanced' gorilla put on underwear, cultivated a frown and began his first lecture tour, . . . " H. L. Mencken, from Meditation On Meditation in the Smart Set, June, 1920 pp 45-46 In our opinion there is no field of clinical medicine in such a state of dynamic disequilibrium as clin ical thyroidology. Thyroid diseases are very common. The moderately complex but easily understandable physiological interrelationships between the thyroid, pituitary and hypothalamus have provided stimuli for the application of mod ern technology in the development of an array of diagnostic procedures. Although therapeutic methods have been more stable, and recent advances more limited, their application by phy- Joel I. Hambufl~er. M. D. sicians representing different disciplines has pro vided an ample basis for the expression of differ ing viewpoints. Unfortunately there are few opportunities for in-depth exploration of different attitudes and experience relevant to issues of current interest. The review process employed by medical journals often seems to stifle the expression of controver sial viewpoints.

Diagnostics Methods in Clinical Thyroidology
Diagnostics Methods in Clinical Thyroidology

Author: Joel I. Hamburger

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 259

ISBN-13: 1461236126

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Diagnostic Methods in Clinical Thyroidology provides a forum for discussion of controversial issues in three major categories: diagnosis of thyroid function, non-invasive evaluation of structural abnormalities, and needle biopsy diagnosis of thyroid nodules. For each category, a free interchange of ideas based on extensive clinical experience is followed by a summary that strives to resolve these controversial issues within a framework of sound clinical practice. The volume will this serve as a ready reference for the many physicians who evaluate thyroid patients.

Diagnosis and Management of Endocrine-related Tumors
Diagnosis and Management of Endocrine-related Tumors

Author: Richard J. Santen

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 462

ISBN-13: 1461328497

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Patients with a variety of tumors present to the physician because of clinical manifestations of hormones secreted in excess. This phenomenon attracted the investigative interest of such pioneers as Harvey Cushing who recognized that pituitary tumors may cause acromegaly and Charles Mayo who associated hyper tension with adrenal medullary neoplasms. Current int~rest in endocrine-related tumors has intensified because of the explosive development of newer methodol ogy for their study. Specific measurements of secretory products, hybridization assays to identify products of genomic translation and quantitative assessment of tissue hormone receptors have provided means of characterizing and precisely following patients with endocrine-related tumors. Treatments based upon these advances are rapidly proliferating. The current volume attempts to synthesize much of this recent information with the goal of providing a sound basis for making clinical judgements regarding diagnosis and management. Tumors of endocrine glandular tissues commonly confront practicing physi cians with difficult management problems. Several unique features of these tumors necessitate collaboration among various specialty disciplines in order to resolve these problems and to provide a high level of clinical care. For example, endocrine neoplasms secrete active hormones or hormone precursors which produce clinical manifestations most familiar to endocrinologists. Certain thera pies such as radioactive iodine for thyroid cancer take advantage of the hormone responsiveness of these tumors to facilitate treatment. These aspects require individuals trained in endocrinology to implement complex diagnostic and thera peutic maneuvers.

Malignant Tumors of the Thyroid
Malignant Tumors of the Thyroid

Author: Rhoda H. Cobin

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 308

ISBN-13: 146139127X

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Thyroid carcinoma is an uncommon malignan ing the available non-human lines, as models cy. In the vast majority of patients, if treated for cell cycle studies and oncogene/anti appropriately, it is associated with a benign oncogene regulation, because they are unaware clinical course. Why then does it hold a con of the often fundamental dichotomy between tinuing fascination for so many physicians? thyroid malignancy and prognosis. Third, the The answer is probably directly dependent very nature of the benign clinical course has suggested to the major health research fund on the very benign nature of most thyroid ing agencies that thyroid cancer is not worthy maligllancies. While there are terrible excep of study in a time of scarce resources. tions, the follicular and papillary thyroid can Nothing could be further from the truth. cers behave in a way quite alien to "common" This gratifying clinical course is the very reason neoplasia, since they grow and metastasize why the study of human thyroid cancer has the slowly. We believe that if only we could under potential for contributing further to our fun stand such a transformed state, we would be able to learn a great deal about the normal and damental understanding of malignancy and, abnormal regulation of the cell cycle and im perhaps more importantly, the mechanisms by prove our understanding of cancer. which the human body can resist neoplastic However, recent advances in the biology of cells.

Advances in Perinatal Thyroidology
Advances in Perinatal Thyroidology

Author: Barry B. Bercu

Publisher: Springer Science & Business Media

Published: 2013-03-08

Total Pages: 276

ISBN-13: 1468459732

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Perinatal problems in thyroid gland physiology are common but complicated and present a diagnostic dilemma for the primary clinician. In December 1990, an international group of basic and clinical investigators gathered in Longboat Key, Florida to address these issues. The participants included internists, obstetricians, pedia tricians, neurologists, pathologists and basic scientists in cellular metabolism, endocrine physiology, and molecular biology. The presentations contained within this book bring together their most current and vital research related to the field of perinatal thyroidology. This book is based on the dynamic and fruitful exchange of the participants at the symposium. We are indebted to these individuals whose valuable insights and efforts are contained within this text. Barry B. Bercu Dorothy I. Shulman vii CONTENTS Session I Mechanism of Thyroid Hormone Action 1 Leslie J. DeGroot Thyroid System Ontogeny in the Sheep: A Model for Precocial Mammalian Species • . . • • 11 Delbert A. Fisher Pathologic Studies of Fetal Thyroid 27 Development • • • • • • • Douglas R. Shanklin Thyroid Hormone Control of Brain and Motor Development: Molecular, Neuroanatomical, 47 and Behavioral Studies • • • • • • • S. A. Stein, P. M. Adams, D. R. Shanklin, G. A. Mihailoff, and M. B. Palnitkar The Thyroidectomized Pregnant Rat: An Animal Model to Study Fetal Effects of Maternal Hypothyroidism 107 Susan P. Porterfield and Chester E.

Thyroid Diseases
Thyroid Diseases

Author: Fabrizio Monaco

Publisher: CRC Press

Published: 1993-06-24

Total Pages: 692

ISBN-13: 9780849348211

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Thyroid Diseases: Clinical Fundamentals and Therapy provides a wide-ranging examination of all clinically significant areas of thyroid diseases. Underlying physiological principles are closely linked to the clinical situation and practical therapeutic interventions. The book examines the clinical course, therapy, and final outcome of thyroid diseases, particularly the bimodal and transient evolution of several thyroid diseases. It also discusses the medical, surgical, and radiometabolic therapy of thyroid diseases, stressing the pros and cons of each therapeutic modality. More than 80 acknowledged experts from North America, Europe, and Japan have contributed to this exceptional reference volume, making it essential for physiologists, clinical endocrinologists, radiologists, researchers in nuclear medicine, oncologists, and radiotherapists.

Surgical Endocrinology
Surgical Endocrinology

Author: John Lynn

Publisher: Butterworth-Heinemann

Published: 2013-10-22

Total Pages: 596

ISBN-13: 1483193829

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Surgical Endocrinology presents the fundamentals and practical application of the subject matter. It discusses the molecular background and physiology of the endocrine systems. It addresses the legal aspects of endocrine surgery such as duty of care, and breach of such duty. Some of the topics covered in the book are the principles of endocrine surgery; molecular structures of organisms; physiology of endocrine system; multiple endocrine neoplasia and molecular genetics; non-surgical management of pituitary tumors; assay formulations and automation technology; syndrome of ectopic hormone production; and anesthesia for pituitary surgery. The classifications of endocrine problems for pregnant women are fully covered. The definition and symptoms of thyrotoxicosis are discussed in detail. The text describes in depth the different histological imaging methods. The anatomy and surgery of anterior pituitary are completely presented. A chapter is devoted to the classification of pituitary adenomas and other tumours. The book can provide useful information to surgeons, doctors, students, and researchers.

Thyroid Cancer
Thyroid Cancer

Author: Georg Riccabona

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 253

ISBN-13: 364271210X

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In a period of controversial attitudes to thyroid cancer, this book aims to correlate recent progress in basic sciences with new clinical management possibilities. It deals with the epidemiology, pathology, pathophysiology, etiology, diagnosis, therapy and follow-up of this disease based on 27 years' experience with some 2000 thyroid cancer cases. The inclusion of ultrasound, CT, NMR imaging and modern surgical techniques for combined treatment modalities is new. Guidelines for further research and improved therapy are set and an extensive review of the literature is provided. This up-to-date survey will offer clinicians, surgeons and researchers a better understanding of thyroid cancer in its entirety.

Endocrine Surgery
Endocrine Surgery

Author: I. D. A. Johnston

Publisher: Butterworth-Heinemann

Published: 2013-10-22

Total Pages: 222

ISBN-13: 1483165302

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Butterworths International Medical Review, Surgery 2: Endocrine Surgery is a 12-chapter text that describes various surgical procedures for the management of a specific endocrine problem. This book deals first with the principles of thyroidectomy and its application in thyrotoxicosis management. The subsequent chapter discusses the management of clinically solitary nodules without definite evidence of malignancy, such as lower cervical adenopathy or recurrent laryngeal nerve palsy. This topic is followed by considerations of reoperative parathyroid surgery; adrenalectomy for Cushing's syndrome management; percutaneous transhepatic portal and pancreatic vein catheterization for patients with organic hyperinsulinism, hypergastrinemia, and carcinoid syndrome; and pancreatic transplantation. This text further examines some surgical considerations of pancreatic islet cell and the pituitary in patients with multiple endocrine neoplasia type I. The concluding chapters explore the benefits and limitations of pre- and post-operative treatments of gastrinoma. These chapters also describe the principles and application of surgical treatments in primary aldosteronism and pheochromocytoma. This work will be of great value to established and in training endocrine surgeons, endocrinologists, and workers in other fields, including radiology and pathology.