Targeted therapies of rheumatic diseases have become a reality and have completely changed patient care as well as patient expectations. Initial success with therapies aimed at blocking TNF and IL-1 has stimulated the development of additional targeted approaches focused on other cytokines as well as specific cells and pathways involved in the path
This textbook serves as a comprehensive reference on the latest science underlying the development of biological therapies, as well as their use in animal and human studies of rheumatological disease. Part A covers targets of emerging therapies - targeting/manipulating cells, targeting cell surface receptors, targeting cytokines, inflammatory mediators and transcription factors, and targeting plasma molecules. Part B then examines the use and implementation of these new therapies in the clinic, covering their use in treating specific rheumatological conditions. Part C discusses issues relating to study design and regulatory issues in the US and Europe.
Leading clinicians and clinical researchers discuss in practical detail the newest treatments used in rheumatic diseases, emphasizing-without neglecting current standard treatments-those experimental therapies now undergoing clinical trials and poised for early introduction into the rheumatology armamentarium. The diseases and therapeutic regimes examined here range from rheumatoid arthritis and its treatment by gene therapy, to osteoarthritis and systemic autoimune diseases. Each chapter is organized so that the busy clinician can quickly obtain all the information needed optimal patient treatment. This includes an analysis of the pathogenic mechanisms that explain the molecular basis of the newer therapeutics, reviews of animal data and the results of clinical trials, and recommendations concerning use, side effects, and precautions.
Michael H. Weisman, Michael Weinblatt, James S Louie, and Ronald Van Vollenhoven offer their unique insights into choosing the correct pharmacological and non-pharmacological therapies for your patients. Chapters cover the full breadth of rheumatic diseases, rheumatoid arthritis, lupus, connective tissue diseases, osteoporosis, regional pain disorders, and fibromyalgia. The full-color design presents detailed clinical photographs and treatment algorithms for visual guidance and easy reference. Covers the treatment of pediatric patients as well as adults so that you can properly address the particular needs of any patient you see. Features the guidance and specific recommendations of experts from United States and Europe for a state-of-the-art approach to the variety of treatments currently in use. Displays the clinical manifestations of rheumatic diseases in full color, along with treatment algorithms for easy at-a-glance reference.
This volume features key presentations from the 6th International Congress of Autoimmunity. The International Congress of Autoimmunity has become established as one of the major meetings in the field of immunology, with presentations covering every aspect of basic research in the hopes of clarifying pathogenesis of autoimmune disease as well as providing information on the latest innovations in biological and other modes of treatment. The goal of this volume is to present cutting edge research that focuses in particular on newer diagnostic tools and newer therapies for human autoimmune disease. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member.
This brand new textbook of rheumatoid arthritis (RA) is an important addition to the Oxford Textbooks in Rheumatology series, and provides a comprehensive overview of both the scientific and clinical aspects of the disease. Divided into eight sections - from the history, diagnosis, and epidemiology of the disease, through the pathogenesis, clinical presentation, and assessment to treatments and management strategies, both drug- and non-drug based - each chapter is written by leading clinicians and scientists in the field to deliver a contemporary view of RA. During the past two decades there have been revolutionary changes in the understanding and management of rheumatoid arthritis, in particular the development of biological treatments. This has had wide-ranging effects on almost all aspects of treatment, from effectiveness and intensity to the nature and the cost. Providing a comprehensive account of the modern ideas about the disease, the Oxford Textbook of Rheumatoid Arthritis is a key new addition to the literature, with each chapter providing a detailed background, key recent advances, and areas of doubt and future developments. Featuring over 170 photographs, radiological images, and clinical charts to aid both diagnosis and illustrate the rationale behind key scientific studies, this new title will prove an indispensable resource for specialist rheumatologists, trainees in rheumatology, and other members of the multi-disciplinary team.
This book provides readers with an up-to-date and comprehensive view on the resolution of inflammation and on new developments in this area, including pro-resolution mediators, apoptosis, macrophage clearance of apoptotic cells, possible novel drug developments.
A strong clinical emphasis is present throughout this volume from the first section of commonly presenting problems through to the section addressing problems shared with a range of other clinical sub-specialties.
""Frontiers in Medicinal Chemistry" is an Ebook series devoted to the review of areas of important topical interest to medicinal chemists and others in allied disciplines. "Frontiers in Medicinal Chemistry" covers all the areas of medicinal chemistry, incl"
