Community Series in Identification, Function and Mechanisms of Interferon Induced Genes Associated with Viruses, volume II
Author: Chang Li
Publisher: Frontiers Media SA
Published: 2023-09-13
Total Pages: 159
ISBN-13: 2832533884
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Community Series in Antiviral Innate Immune Sensing, Regulation, and Viral Immune Evasion, volume II
Author: Chenhe Su
Publisher: Frontiers Media SA
Published: 2024-01-18
Total Pages: 203
ISBN-13: 2832541402
DOWNLOAD EBOOKThis Research Topic is the second volume of the “Community Series in Antiviral Innate Immune Sensing, Regulation, and Viral Immune Evasion”. Please see the first volume here. The innate immune system is crucial to defend against viruses or other pathogenic microbes in the early phases of infection. The response starts with detecting evolutionarily conserved structures, termed pathogen-associated molecular patterns (PAMPs), by a set of germline-encoded pattern-recognition receptors (PRRs). Following the detection of specific viral PAMPs, PRRs trigger the activation of intracellular signaling cascades, ultimately leading to the induction of type I interferons (IFNs), pro-inflammatory cytokines, and antiviral genes through the activation of interferon regulatory factor 3 (IRF3) and IRF7. Antiviral pathways need to be tightly regulated to ensure successful antiviral defenses and avoid aberrant or dysregulation of host immune signaling. We believe that the Research Topic will give updated insights into the dynamic fields of PAMPs sensing in antiviral innate immunity and viral immune evasion. We hope it will serve the purpose of encouraging new research. This Research Topic will provide an overall picture of antiviral innate immune sensing signal pathways, regulation, and viral immune evasion. We welcome the submission of Original Research, Review, Mini-Review, Hypothesis and Theory, and Perspective articles that cover, but are not limited to, the following subtopics:
Community Series in New Insights in Sepsis Pathogenesis and Renal Dysfunction: Immune Mechanisms and Novel Management Strategies, volume II
Author: Alessandra Stasi
Publisher: Frontiers Media SA
Published: 2023-11-17
Total Pages: 124
ISBN-13: 2832539041
DOWNLOAD EBOOKThis Research Topic is the second volume of the “New Insights in Sepsis Pathogenesis and Renal Dysfunction: Immune Mechanisms and Novel Management Strategies” Community Series. Please see the first volume here. Sepsis is a systemic inflammatory response to an active infectious process in the host; the symptoms are mainly produced by host defense systems rather than by the invading pathogens, involving pro-inflammatory and anti-inflammatory processes. The association of Acute Kidney Injury (AKI) and sepsis ranges from 45% to 70% of cases, with a significantly increased risk of death, progression toward chronic kidney disease and increased health resource utilization. Despite relevant therapeutic advances, sepsis-related AKI remains associated with an unacceptably high morbidity/mortality risk, increased health resource utilization, as well as - in survivors - with increased risk of transition to chronic kidney disease. Currently there are no approved treatments for sepsis-related AKI. The main objective of this research topic is to shed new light on sepsis pathogenesis and provide new potential therapeutic strategies to prevent the progression to AKI.
Community series in translational insights into mechanisms and therapy of organ dysfunction in sepsis and trauma, volume II
Author: Christoph Thiemermann
Publisher: Frontiers Media SA
Published: 2023-06-27
Total Pages: 179
ISBN-13: 2832526608
DOWNLOAD EBOOKFields Virology: Emerging Viruses
Author: Peter M. Howley
Publisher: Lippincott Williams & Wilkins
Published: 2020-02-11
Total Pages: 2737
ISBN-13: 1975112555
DOWNLOAD EBOOKNow in four convenient volumes, Field’s Virology remains the most authoritative reference in this fast-changing field, providing definitive coverage of virology, including virus biology as well as replication and medical aspects of specific virus families. This volume of Field’s Virology: Emerging Viruses, 7th Edition covers recent changes in emerging viruses, providing new or extensively revised chapters that reflect these advances in this dynamic field.
SARS, MERS and other Viral Lung Infections
Author: David S. Hui
Publisher: European Respiratory Society
Published: 2016-06-01
Total Pages: 148
ISBN-13: 1849840709
DOWNLOAD EBOOKViral respiratory tract infections are important and common causes of morbidity and mortality worldwide. In the past two decades, several novel viral respiratory infections have emerged with epidemic potential that threaten global health security. This Monograph aims to provide an up-to-date and comprehensive overview of severe acute respiratory syndrome, Middle East respiratory syndrome and other viral respiratory infections, including seasonal influenza, avian influenza, respiratory syncytial virus and human rhinovirus, through six chapters written by authoritative experts from around the globe.
The Threat of Pandemic Influenza
Author: Institute of Medicine
Publisher: National Academies Press
Published: 2005-04-09
Total Pages: 431
ISBN-13: 0309095042
DOWNLOAD EBOOKPublic health officials and organizations around the world remain on high alert because of increasing concerns about the prospect of an influenza pandemic, which many experts believe to be inevitable. Moreover, recent problems with the availability and strain-specificity of vaccine for annual flu epidemics in some countries and the rise of pandemic strains of avian flu in disparate geographic regions have alarmed experts about the world's ability to prevent or contain a human pandemic. The workshop summary, The Threat of Pandemic Influenza: Are We Ready? addresses these urgent concerns. The report describes what steps the United States and other countries have taken thus far to prepare for the next outbreak of "killer flu." It also looks at gaps in readiness, including hospitals' inability to absorb a surge of patients and many nations' incapacity to monitor and detect flu outbreaks. The report points to the need for international agreements to share flu vaccine and antiviral stockpiles to ensure that the 88 percent of nations that cannot manufacture or stockpile these products have access to them. It chronicles the toll of the H5N1 strain of avian flu currently circulating among poultry in many parts of Asia, which now accounts for the culling of millions of birds and the death of at least 50 persons. And it compares the costs of preparations with the costs of illness and death that could arise during an outbreak.
Immunoregulatory Mechanisms of Interferon
Author: Jorg Hermann Fritz
Publisher: Frontiers Media SA
Published: 2020-03-11
Total Pages: 362
ISBN-13: 2889632806
DOWNLOAD EBOOKInterferons (IFN) belong to the family of cytokines and have been described first in the late 1950s as an inhibitory factor of viral replication. Since then, the impact of interferon has been greatly expanded and its function comprises a role not only in different types of infection, cancer and autoimmunity but importantly also in immunehomeostasis. IFN have important anti-viral effects but it is becoming more and more evident that they are true immunomodulators and have an important impact on the development and maintenance of innate and adaptive immunity.
How Tobacco Smoke Causes Disease
Author: United States. Public Health Service. Office of the Surgeon General
Publisher:
Published: 2010
Total Pages: 728
ISBN-13:
DOWNLOAD EBOOKThis report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
Flu
Author: Gina Kolata
Publisher: Farrar, Straus and Giroux
Published: 2011-04-01
Total Pages: 378
ISBN-13: 1429979356
DOWNLOAD EBOOKVeteran journalist Gina Kolata's Flu: The Story of the Great Influenza Pandemic of 1918 and the Search for the Virus That Caused It presents a fascinating look at true story of the world's deadliest disease. In 1918, the Great Flu Epidemic felled the young and healthy virtually overnight. An estimated forty million people died as the epidemic raged. Children were left orphaned and families were devastated. As many American soldiers were killed by the 1918 flu as were killed in battle during World War I. And no area of the globe was safe. Eskimos living in remote outposts in the frozen tundra were sickened and killed by the flu in such numbers that entire villages were wiped out. Scientists have recently rediscovered shards of the flu virus frozen in Alaska and preserved in scraps of tissue in a government warehouse. Gina Kolata, an acclaimed reporter for The New York Times, unravels the mystery of this lethal virus with the high drama of a great adventure story. Delving into the history of the flu and previous epidemics, detailing the science and the latest understanding of this mortal disease, Kolata addresses the prospects for a great epidemic recurring, and, most important, what can be done to prevent it.
