Photodynamic Inactivation of Microbial Pathogens
Photodynamic Inactivation of Microbial Pathogens

Author: Michael R Hamblin

Publisher: Royal Society of Chemistry

Published: 2011-06-06

Total Pages: 451

ISBN-13: 1849733082

DOWNLOAD EBOOK

Photodynamic therapy (PDT) was discovered over one hundred years ago after observing the death of microorganisms upon exposure to dyes and light. It is the combination of non-toxic dyes and harmless visible light that, in the presence of oxygen, produce highly toxic reactive species. The principal medical application during the last century was in cancer therapy but, in these days of rising antibiotic resistance, PDT shows increasing promise as an alternative approach to treating infections. PDT has also been used in blood product sterilization, peridontology, acne reduction, and the treatment of viral lesions such as those caused by human papilloma virus. It may also have potential as an environmentally friendly pesticide. This is the first and only book to comprehensively cover the use of light and photosensitising agents for controlling microbial pathogens. It provides a comprehensive and up-to-date coverage of an emerging field. There are several chapters on the design of antimicrobial photosensitizers, their use to kill pathogenic organisms and their success in treating infections in animal models. It has long been known that gram-positive bacteria are highly susceptible to photoinactivation but the book also discusses means of widening the range of microorganisms that can be tackled by PDT. Edited by two pioneers in the application of PDT to medical and environmental issues, this book covers the basic science, translational research in animals, and the clinical applications in various medical specialities. It represents an indispensable resource for microbiologists and infectious disease doctors as well as dentists, dermatologists, gastroenterologists and transfusion specialists.

Aggregation-Induced Emission (AIE)
Aggregation-Induced Emission (AIE)

Author: Jianwei Xu

Publisher: Elsevier

Published: 2022-04-17

Total Pages: 698

ISBN-13: 0128243368

DOWNLOAD EBOOK

Aggregation-Induced Emission (AIE): A Practical Guide introduces readers to the topic, guiding them through fundamental concepts and the latest advances in applications. The book covers concepts, principles and working mechanisms of AIE in AIE-active luminogens, with different classes of AIE luminogens reviewed, including polymers, three-dimensional frameworks (MOFs and COFs) and supramolecular gels. Special focus is given to the structure-property relationship, structural design strategies, targeted properties and application performance. The book provides readers with a deep understanding, not only on the fundamental principles of AIE, but more importantly, on how AIE luminogens and AIE properties can be incorporated in material development. - Provides the fundamental principles, design and synthesis strategies of aggregation induced emission materials - Reviews the most relevant applications in materials design for stimuli-responsive materials, biomedical applications, chemo-sensing and optoelectronics - Emphasizes structural design and its connection to aggregation induced emission properties, also exploring the structure-property relationship

Near-infrared Nanomaterials
Near-infrared Nanomaterials

Author: Fan Zhang

Publisher: Royal Society of Chemistry

Published: 2016-08-05

Total Pages: 429

ISBN-13: 1782623930

DOWNLOAD EBOOK

In the last decade, bioimaging and therapy based on near-infrared (NIR) nanomaterials have played an important role in biotechnology due to their intrinsic advantages when compared with the traditional imaging probe and medicine. NIR nanomaterials allow deeper penetration depth, low detection threshold concentration and better targeted performance. This book systematically summarises the recent progress in the fabrication and application of NIR nanomaterials for biomedical imaging and therapy, and discusses the advantages, challenges and opportunities available. Near-infrared Nanomaterials contains achapter highlighting the outlook of these materials, detailing novel ideas for the further application of NIR nanomaterials in bioimaging and medicine. Written by leading experts working in the field, this title will have broad appeal to those working in chemistry, materials science, nanotechnology, biology, bioengineering, biomedical science and biophysics.

Correlative Light and Electron MIcroscopy
Correlative Light and Electron MIcroscopy

Author: Thomas Muller-Reichert

Publisher: Academic Press

Published: 2012-08-10

Total Pages: 466

ISBN-13: 0124160263

DOWNLOAD EBOOK

The combination of electron microscopy with transmitted light microscopy (termed correlative light and electron microscopy; CLEM) has been employed for decades to generate molecular identification that can be visualized by a dark, electron-dense precipitate. This new volume of Methods in Cell Biology covers many areas of CLEM, including a brief history and overview on CLEM methods, imaging of intermediate stages of meiotic spindle assembly in C. elegans embryos using CLEM, and capturing endocytic segregation events with HPF-CLEM. Covers many areas of CLEM by the best international scientists in the field Includes a brief history and overview on CLEM methods

Mitochondria and Cancer
Mitochondria and Cancer

Author: Keshav Singh

Publisher: Springer Science & Business Media

Published: 2009-04-05

Total Pages: 294

ISBN-13: 0387848355

DOWNLOAD EBOOK

Nearly a century of scientific research has revealed that mitochondrial dysfunction is one of the most common and consistent phenotypes of cancer cells. A number of notable differences in the mitochondria of normal and cancer cells have been described. These include differences in mitochondrial metabolic activity, molecular composition of mitochondria and mtDNA sequence, as well as in alteration of nuclear genes encoding mitochondrial proteins. This book, Mitochondria and Cancer, edited by Keshav K. Singh and Leslie C. Costello, presents thorough analyses of mitochondrial dysfunction as one of the hallmarks of cancer, discusses the clinical implications of mitochondrial defects in cancer, and as unique cellular targets for novel and selective anti-cancer therapy.

TiO2 Nanoparticles
TiO2 Nanoparticles

Author: Aiguo Wu

Publisher: John Wiley & Sons

Published: 2020-06-02

Total Pages: 252

ISBN-13: 3527347240

DOWNLOAD EBOOK

A unique book that summarizes the properties, toxicology, and biomedical applications of TiO2-based nanoparticles Nanotechnology is becoming increasingly important for products used in our daily lives. Nanometer-sized titanium dioxide (TiO2) are widely used in industry for different purposes, such as painting, sunscreen, printing, cosmetics, biomedicine, and so on. This book summarizes the advances of TiO2 based nanobiotechnology and nanomedicine, covering materials properties, toxicological research, and biomedical application, such as antibacter, biosensing, and cancer theranostics. It uniquely integrates the TiO2 applications from physical properties, toxicology to various biomedical applications, and includes black TiO2 based cancer theranostics. Beginning with a comprehensive introduction to the properties and applications of nanoparticles, TiO2 Nanoparticles: Applications in Nanobiotechnology, Theranostics and Nanomedicine offers chapters on: Toxicity of TiO2 Nanoparticles; Antibacterial Applications of TiO2 Nanoparticles; Surface Enhanced Raman Spectrum of TiO2 Nanoparticle for Biosensing (TiO2 Nanoparticle Served as SERS Sensing Substrate); TiO2 as Inorganic Photosensitizer for Photodynamic Therapy; Cancer Theranostics of Black TiO2 Nanoparticles; and Neurodegenerative Disease Diagnostics and Therapy of TiO2-Based Nanoparticles. This title: Blends the physical properties, toxicology of TiO2 nanoparticles to the many biomedical applications Includes black TiO2 based cancer theranostics in its coverage Appeals to a broad audience of researchers in academia and industry working on nanomaterials-based biosensing, drug delivery, nanomedicine TiO2 Nanoparticles: Applications in Nanobiotechnology, Theranostics and Nanomedicine is an ideal book for medicinal chemists, analytical chemists, biochemists, materials scientists, toxicologists, and those in the pharmaceutical industry.

Pharmacology of Mitochondria
Pharmacology of Mitochondria

Author: Harpreet Singh

Publisher: Springer

Published: 2017-08-11

Total Pages: 491

ISBN-13: 3319573136

DOWNLOAD EBOOK

This special book is conceived to highlight mitochondrial structural and functional integrity and how they are associated with several human diseases such as cardiovascular, cancer, renal, neurological disorder, and genetic disorders. The chapters contributed by leading mitochondrial researchers in the handbook will take us through the novel pharmacological strategies via mitochondria to understand their physiological and pathological role as well as present them as therapeutic targets.

Coumarin and Its Derivatives
Coumarin and Its Derivatives

Author: Maria João Matos

Publisher: Mdpi AG

Published: 2021-12-29

Total Pages: 416

ISBN-13: 9783036527758

DOWNLOAD EBOOK

Coumarins are widely distributed in nature and can be found in a large number of naturally occurring and synthetic bioactive molecules. The unique and versatile oxygen-containing heterocyclic structure makes them a privileged scaffold in Medicinal Chemistry. Many coumarin derivatives have been extracted from natural sources, designed, synthetized, and evaluated on different pharmacological targets. In addition, coumarin-based ion receptors, fluorescent probes, and biological stains are growing quickly and have extensive applications to monitor timely enzyme activity, complex biological events, as well as accurate pharmacological and pharmacokinetic properties in living cells. The extraction, synthesis, and biological evaluation of coumarins have become extremely attractive and rapidly developing topics. A large number of research and review papers have compiled information on this important family of compounds in 2020. Research articles, reviews, communications, and concept papers focused on the multidisciplinary profile of coumarins, highlighting natural sources, most recent synthetic pathways, along with the main biological applications and theoretical studies, were the main focus of this book. The huge and growing range of applications of coumarins described in this book is a demonstration of the potential of this family of compounds in Organic Chemistry, Medicinal Chemistry, and different sciences related to the study of natural products. This book includes 23 articles: 17 original papers and six review papers.

Inorganic Chemical Biology
Inorganic Chemical Biology

Author: Gilles Gasser

Publisher: John Wiley & Sons

Published: 2014-06-23

Total Pages: 437

ISBN-13: 111851002X

DOWNLOAD EBOOK

Understanding, identifying and influencing the biological systems are the primary objectives of chemical biology. From this perspective, metal complexes have always been of great assistance to chemical biologists, for example, in structural identification and purification of essential biomolecules, for visualizing cellular organelles or to inhibit specific enzymes. This inorganic side of chemical biology, which continues to receive considerable attention, is referred to as inorganic chemical biology. Inorganic Chemical Biology: Principles, Techniques and Applications provides a comprehensive overview of the current and emerging role of metal complexes in chemical biology. Throughout all of the chapters there is a strong emphasis on fundamental theoretical chemistry and experiments that have been carried out in living cells or organisms. Outlooks for the future applications of metal complexes in chemical biology are also discussed. Topics covered include: • Metal complexes as tools for structural biology • IMAC, AAS, XRF and MS as detection techniques for metals in chemical biology • Cell and organism imaging and probing DNA using metal and metal carbonyl complexes • Detection of metal ions, anions and small molecules using metal complexes • Photo-release of metal ions in living cells • Metal complexes as enzyme inhibitors and catalysts in living cells Written by a team of international experts, Inorganic Chemical Biology: Principles, Techniques and Applications is a must-have for bioinorganic, bioorganometallic and medicinal chemists as well as chemical biologists working in both academia and industry.

Chemical Aspects of Photodynamic Therapy
Chemical Aspects of Photodynamic Therapy

Author: Raymond Bonnett

Publisher: CRC Press

Published: 2000-08-07

Total Pages: 322

ISBN-13: 1482296950

DOWNLOAD EBOOK

Photodynamic therapy (PDT) is a ground breaking medical technique which uses lasers to activate light-sensitive chemicals to treat cancer and other diseases without resorting to surgery. For the first time, Chemical Aspects of Photodynamic Therapy introduces in an accessible way the physics, chemistry and biology behind the technique. This highly a